FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling

VEGF (vascular endothelial growth factor-A) signaling to the endothelial cell (EC) through VEGFR2 (VEGF receptor-2) is the principal cue driving new blood vessel formation. FGD5 (faciogenital dysplasia-5)-a Rho-family guanine nucleotide exchange factor-is selectively expressed in EC. Deficiency of F...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2017-12, Vol.37 (12), p.2301-2310
Hauptverfasser:	Farhan, Maikel A, Azad, Abul K, Touret, Nicolas, Murray, Allan G
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Movement Cell Proliferation Cells, Cultured Cortactin - metabolism Cytoskeleton - enzymology Endosomes - enzymology Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Human Umbilical Vein Endothelial Cells - enzymology Humans Lysosomes - enzymology Mechanistic Target of Rapamycin Complex 2 - metabolism Neovascularization, Physiologic Phosphatidylinositol 3-Kinase - metabolism Protein Binding Proteolysis Proto-Oncogene Proteins c-akt - metabolism Pseudopodia - enzymology RNA Interference Signal Transduction Time Factors Transfection Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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