Gene-environment interaction and psychiatric disorders: Review and future directions
Empirical studies suggest that psychiatric disorders result from a complex interplay between genetic and environmental factors. Most evidence for such gene-environment interaction (GxE) is based on single candidate gene studies conducted from a Diathesis-Stress perspective. Recognizing the short-com...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2018-05, Vol.77, p.133-143 |
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| container_title | Seminars in cell & developmental biology |
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| creator | Assary, Elham Vincent, John Paul Keers, Robert Pluess, Michael |
| description | Empirical studies suggest that psychiatric disorders result from a complex interplay between genetic and environmental factors. Most evidence for such gene-environment interaction (GxE) is based on single candidate gene studies conducted from a Diathesis-Stress perspective. Recognizing the short-comings of candidate gene studies, GxE research has begun to focus on genome-wide and polygenic approaches as well as drawing on different theoretical concepts underlying GxE, such as Differential Susceptibility. After reviewing evidence from candidate GxE studies and presenting alternative theoretical frameworks underpinning GxE research, more recent approaches and findings from whole genome approaches are presented. Finally, we suggest how future GxE studies may unpick the complex interplay between genes and environments in psychiatric disorders. |
| doi_str_mv | 10.1016/j.semcdb.2017.10.016 |
| format | Article |
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| subjects | Antisocial Personality Disorder - genetics Attention Deficit Disorder with Hyperactivity - genetics Catechol O-Methyltransferase - genetics Depression - genetics Diathesis-Stress Differential Environment Gene-Environment Interaction Genetic Predisposition to Disease - genetics Genetics Humans Mental Disorders - genetics Monoamine Oxidase - genetics Psychiatry Receptors, Dopamine D4 - genetics Schizophrenia - genetics Serotonin Plasma Membrane Transport Proteins - genetics Stress, Psychological - genetics Stress, Psychological - psychology Susceptibility |
| title | Gene-environment interaction and psychiatric disorders: Review and future directions |
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