The Role of Activating Protein 1 in the Transcriptional Regulation of the Human FCGR2B Promoter Mediated by the -343 G arrow right C Polymorphism Associated with Systemic Lupus Erythematosus

The inhibitory receptor Fc gamma RIIb is a negative regulator of antibody production and inflammatory responses. The -343 G arrow right C polymorphism in the human FCGR2B promoter is associated with systemic lupus erythematosus. The -343 C mutant promoter has decreased transcriptional activity. In t...

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Veröffentlicht in:	The Journal of biological chemistry 2007-01, Vol.282 (3), p.1738-1746
Hauptverfasser:	Olferiev, Mikhail, Masuda, Emi, Tanaka, Shizuko, Blank, Marissa C, Pricop, Luminita
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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