Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin

We investigated the cytoprotective mechanisms of flunarizine in cisplatin-induced death of auditory cells. Concomitant with an increase in viability, treatment with flunarizine resulted in a marked dissociation of Nrf2/Keap1 and subsequent intranuclear translocation of Nrf2, which was mediated by PI...

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Veröffentlicht in:	Cell death and differentiation 2006-10, Vol.13 (10), p.1763-1775
Hauptverfasser:	So, H-S, Kim, H-J, Lee, J-H, Park, S-Y, Park, C, Kim, Y-H, Kim, J-K, Lee, K-M, Kim, K-S, Chung, S-Y, Jang, W-C, Moon, S-K, Chung, H-T, Park, R-K
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals Antioxidants - metabolism Apoptosis Apoptosis - drug effects Base Sequence Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell Line Cisplatin - toxicity DNA, Complementary - genetics Flunarizine - pharmacology Heme Oxygenase-1 - antagonists & inhibitors Heme Oxygenase-1 - genetics In Vitro Techniques Life Sciences Mice NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Organ of Corti - cytology Organ of Corti - drug effects Organ of Corti - metabolism original-paper Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley RNA, Small Interfering - genetics Signal Transduction - drug effects Stem Cells Transcriptional Activation - drug effects
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