Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens
We studied the suppressive effect of poly-γ-glutamate (PGA) on the SOS response of Salmonella typhimurium induced by several direct [furylframide, AF-2; N-methyl- N′-nitro- N-nitrosoguanidine, MNNG; and 4-nitroquinoline 1-oxide, 4NQO] and indirect [3-amino-1-methyl-5 H-pyrido-(4,3- b) indole, Trp-P-...
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| Veröffentlicht in: | Journal of bioscience and bioengineering 2008-06, Vol.105 (6), p.690-693 |
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| creator | Sato, Machiko Kanie, Kyoko Soda, Kenji Yokoigawa, Kumio |
| description | We studied the suppressive effect of poly-γ-glutamate (PGA) on the SOS response of
Salmonella typhimurium induced by several direct [furylframide, AF-2;
N-methyl-
N′-nitro-
N-nitrosoguanidine, MNNG; and 4-nitroquinoline 1-oxide, 4NQO] and indirect [3-amino-1-methyl-5
H-pyrido-(4,3-
b) indole, Trp-P-2; 2-amino-3-methylimidazo (4,5-
f) quinoline, IQ; and 2-amino-3,8-dimethylimidazo (4,5-
f) quinoxaline, MeIQx] mutagens. PGA preparations with average molecular masses of 50, 2000, 4000, 6000, and 8000 kDa from
Bacillus subtilis (chungkookjang) were used. When we used PGA Na salt with a molecular mass of 4000 kDa, the suppression rate increased with increasing PGA concentration; 3% PGA showed 80–90% suppression irrespective of the type of chemical mutagen. PGA preparations with molecular masses of 50 kDa and more than 6000 kDa were less effective. Glutamate and acidic polymers such as carboxymethylcellulose and xanthan gum showed lower suppressive effects than PGA. PGA proved to have high antimutagenic activity. |
| doi_str_mv | 10.1263/jbb.105.690 |
| format | Article |
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Salmonella typhimurium induced by several direct [furylframide, AF-2;
N-methyl-
N′-nitro-
N-nitrosoguanidine, MNNG; and 4-nitroquinoline 1-oxide, 4NQO] and indirect [3-amino-1-methyl-5
H-pyrido-(4,3-
b) indole, Trp-P-2; 2-amino-3-methylimidazo (4,5-
f) quinoline, IQ; and 2-amino-3,8-dimethylimidazo (4,5-
f) quinoxaline, MeIQx] mutagens. PGA preparations with average molecular masses of 50, 2000, 4000, 6000, and 8000 kDa from
Bacillus subtilis (chungkookjang) were used. When we used PGA Na salt with a molecular mass of 4000 kDa, the suppression rate increased with increasing PGA concentration; 3% PGA showed 80–90% suppression irrespective of the type of chemical mutagen. PGA preparations with molecular masses of 50 kDa and more than 6000 kDa were less effective. Glutamate and acidic polymers such as carboxymethylcellulose and xanthan gum showed lower suppressive effects than PGA. PGA proved to have high antimutagenic activity.</description><identifier>ISSN: 1389-1723</identifier><identifier>EISSN: 1347-4421</identifier><identifier>DOI: 10.1263/jbb.105.690</identifier><identifier>PMID: 18640614</identifier><language>eng</language><publisher>Amsterdarm: Elsevier B.V</publisher><subject>antimutagenic activity ; Biological and medical sciences ; Biotechnology ; Dose-Response Relationship, Drug ; Drug Interactions ; Fundamental and applied biological sciences. Psychology ; Mutagens - administration & dosage ; Particle Size ; poly-γ-glutamate ; Polyglutamic Acid - administration & dosage ; Salmonella typhimurium ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - physiology ; SOS response ; SOS Response (Genetics) - drug effects ; SOS Response (Genetics) - physiology</subject><ispartof>Journal of bioscience and bioengineering, 2008-06, Vol.105 (6), p.690-693</ispartof><rights>2008 The Society for Biotechnology, Japan</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-26ebabd87ce453be91589cd9a2f8ca971bb2663e91e26c022266844c8094e5a3</citedby><cites>FETCH-LOGICAL-c418t-26ebabd87ce453be91589cd9a2f8ca971bb2663e91e26c022266844c8094e5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1389172308701324$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20568957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18640614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Machiko</creatorcontrib><creatorcontrib>Kanie, Kyoko</creatorcontrib><creatorcontrib>Soda, Kenji</creatorcontrib><creatorcontrib>Yokoigawa, Kumio</creatorcontrib><title>Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens</title><title>Journal of bioscience and bioengineering</title><addtitle>J Biosci Bioeng</addtitle><description>We studied the suppressive effect of poly-γ-glutamate (PGA) on the SOS response of
Salmonella typhimurium induced by several direct [furylframide, AF-2;
N-methyl-
N′-nitro-
N-nitrosoguanidine, MNNG; and 4-nitroquinoline 1-oxide, 4NQO] and indirect [3-amino-1-methyl-5
H-pyrido-(4,3-
b) indole, Trp-P-2; 2-amino-3-methylimidazo (4,5-
f) quinoline, IQ; and 2-amino-3,8-dimethylimidazo (4,5-
f) quinoxaline, MeIQx] mutagens. PGA preparations with average molecular masses of 50, 2000, 4000, 6000, and 8000 kDa from
Bacillus subtilis (chungkookjang) were used. When we used PGA Na salt with a molecular mass of 4000 kDa, the suppression rate increased with increasing PGA concentration; 3% PGA showed 80–90% suppression irrespective of the type of chemical mutagen. PGA preparations with molecular masses of 50 kDa and more than 6000 kDa were less effective. Glutamate and acidic polymers such as carboxymethylcellulose and xanthan gum showed lower suppressive effects than PGA. PGA proved to have high antimutagenic activity.</description><subject>antimutagenic activity</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mutagens - administration & dosage</subject><subject>Particle Size</subject><subject>poly-γ-glutamate</subject><subject>Polyglutamic Acid - administration & dosage</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - physiology</subject><subject>SOS response</subject><subject>SOS Response (Genetics) - drug effects</subject><subject>SOS Response (Genetics) - physiology</subject><issn>1389-1723</issn><issn>1347-4421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0c1u1DAQB3ALgWgpnLiDL3BBWWzHH_ERVXxJlXpIOVu2M9m6SuxgJ5X2uXgPngmvdgUXTh5bP41m_kboNSU7ymT78cG5HSViJzV5gi5py1XDOaNPj3WnG6pYe4FelPJACFVE0efognaSE0n5JYr9tiwZSgmPgGEcwa84jXhJ06H5_avZT9tqZ7sCThH3tz2udEmxwBH1dppThGmyeD0s92HecthmHOKweRiwO2B_D3PwdsJzbbOHWF6iZ6OdCrw6n1fo7svnu-tvzc3t1-_Xn24az2m3NkyCs27olAcuWgeaik77QVs2dt5qRZ1jUrb1HZj0hLF66zj3HdEchG2v0PtT2yWnnxuU1cyh-OOkEdJWDNWiVVyKCj-coM-plAyjWXKYbT4YSswxXVPTrbUwNd2q35zbbm6G4Z89x1nBuzOwpa49Zht9KH8dI0J2Wqjq3p7caJOx-1zNj54R2hKiqVKtrkKcBNSUHgNkU3yAWHMNuf6RGVL474h_AAUhn8U</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Sato, Machiko</creator><creator>Kanie, Kyoko</creator><creator>Soda, Kenji</creator><creator>Yokoigawa, Kumio</creator><general>Elsevier B.V</general><general>Osaka, Japan: Society for Bioscience and Bioengineering, Japan; Amsterdam, the Netherlands: Distributed outside Japan by Elsevier Science</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20080601</creationdate><title>Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens</title><author>Sato, Machiko ; Kanie, Kyoko ; Soda, Kenji ; Yokoigawa, Kumio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-26ebabd87ce453be91589cd9a2f8ca971bb2663e91e26c022266844c8094e5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>antimutagenic activity</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mutagens - administration & dosage</topic><topic>Particle Size</topic><topic>poly-γ-glutamate</topic><topic>Polyglutamic Acid - administration & dosage</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - physiology</topic><topic>SOS response</topic><topic>SOS Response (Genetics) - drug effects</topic><topic>SOS Response (Genetics) - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Machiko</creatorcontrib><creatorcontrib>Kanie, Kyoko</creatorcontrib><creatorcontrib>Soda, Kenji</creatorcontrib><creatorcontrib>Yokoigawa, Kumio</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of bioscience and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Machiko</au><au>Kanie, Kyoko</au><au>Soda, Kenji</au><au>Yokoigawa, Kumio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens</atitle><jtitle>Journal of bioscience and bioengineering</jtitle><addtitle>J Biosci Bioeng</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>105</volume><issue>6</issue><spage>690</spage><epage>693</epage><pages>690-693</pages><issn>1389-1723</issn><eissn>1347-4421</eissn><abstract>We studied the suppressive effect of poly-γ-glutamate (PGA) on the SOS response of
Salmonella typhimurium induced by several direct [furylframide, AF-2;
N-methyl-
N′-nitro-
N-nitrosoguanidine, MNNG; and 4-nitroquinoline 1-oxide, 4NQO] and indirect [3-amino-1-methyl-5
H-pyrido-(4,3-
b) indole, Trp-P-2; 2-amino-3-methylimidazo (4,5-
f) quinoline, IQ; and 2-amino-3,8-dimethylimidazo (4,5-
f) quinoxaline, MeIQx] mutagens. PGA preparations with average molecular masses of 50, 2000, 4000, 6000, and 8000 kDa from
Bacillus subtilis (chungkookjang) were used. When we used PGA Na salt with a molecular mass of 4000 kDa, the suppression rate increased with increasing PGA concentration; 3% PGA showed 80–90% suppression irrespective of the type of chemical mutagen. PGA preparations with molecular masses of 50 kDa and more than 6000 kDa were less effective. Glutamate and acidic polymers such as carboxymethylcellulose and xanthan gum showed lower suppressive effects than PGA. PGA proved to have high antimutagenic activity.</abstract><cop>Amsterdarm</cop><pub>Elsevier B.V</pub><pmid>18640614</pmid><doi>10.1263/jbb.105.690</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1389-1723 |
| ispartof | Journal of bioscience and bioengineering, 2008-06, Vol.105 (6), p.690-693 |
| issn | 1389-1723 1347-4421 |
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| subjects | antimutagenic activity Biological and medical sciences Biotechnology Dose-Response Relationship, Drug Drug Interactions Fundamental and applied biological sciences. Psychology Mutagens - administration & dosage Particle Size poly-γ-glutamate Polyglutamic Acid - administration & dosage Salmonella typhimurium Salmonella typhimurium - drug effects Salmonella typhimurium - physiology SOS response SOS Response (Genetics) - drug effects SOS Response (Genetics) - physiology |
| title | Suppressive effect of poly-γ-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens |
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