Poly(amidoamine) Dendrimers as a Pharmaceutical Excipient. Are We There yet?

Drug solubility could affect the therapeutic use of a drug because the biological activity of a drug is only possible if some fraction of a dissolved drug can permeate and overcome biological membranes to reach its site of action. The solubility-permeation interplay is therefore, probably the most i...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of pharmaceutical sciences 2018-01, Vol.107 (1), p.75-83
Hauptverfasser:	Otto, Daniel P., de Villiers, Melgardt M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals dendrimer Dendrimers - chemistry Drug Carriers - chemistry Drug Liberation - drug effects excipient Excipients - chemistry Humans PAMAM permeability Polyamines - chemistry solubility Solubility - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!