Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors

Nicotinic acetylcholine receptors (nAChRs) are present in high density in insect nervous tissue and are targeted by neonicotinoid insecticides. Improved understanding of the actions of these insecticides will assist in the development of new compounds. Here, we have used whole‐cell patch‐clamp recor...

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Veröffentlicht in:	Journal of neurochemistry 2006-10, Vol.99 (2), p.608-615
Hauptverfasser:	Brown, Laurence A., Ihara, Makoto, Buckingham, Steven D., Matsuda, Kazuhiko, Sattelle, David B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholine - pharmacology Animals Animals, Genetically Modified Binding, Competitive - drug effects Binding, Competitive - physiology Biological and medical sciences Cell receptors Cell structures and functions Cells, Cultured Central nervous system Central Nervous System - cytology Central Nervous System - drug effects Central Nervous System - metabolism Central neurotransmission. Neuromudulation. Pathways and receptors clothianidin Dose-Response Relationship, Drug Drosophila Drosophila melanogaster Fundamental and applied biological sciences. Psychology Guanidines - chemistry Guanidines - pharmacology imidacloprid Imidazoles - chemistry Imidazoles - pharmacology Insecticides Insecticides - chemistry Insecticides - pharmacology Insects Larva - cytology Larva - drug effects Larva - metabolism Membrane Potentials - drug effects Membrane Potentials - physiology Molecular and cellular biology Molecular Structure Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Neonicotinoids Nervous system Neurons Neurons - drug effects Neurons - metabolism Neurosciences Nicotine - pharmacology Nicotinic Agonists - chemistry Nicotinic Agonists - pharmacology Nitro Compounds Patch-Clamp Techniques patch‐clamp Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism super agonist Thiazoles Vertebrates: nervous system and sense organs
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