l -Carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture

Abstract 1-Methyl-4-phenylpyridinium ion (MPP+ ), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson’s disease-like syndrome with an elevation of intracellular reactive oxygen species (ROS) and apoptosis. l -Carnitine plays an integral...

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Veröffentlicht in:	Neuroscience 2007-01, Vol.144 (1), p.46-55
Hauptverfasser:	Wang, C, Sadovova, N, Ali, H.K, Duhart, H.M, Fu, X, Zou, X, Patterson, T.A, Binienda, Z.K, Virmani, A, Paule, M.G, Slikker, W, Ali, S.F
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - antagonists & inhibitors 1-Methyl-4-phenylpyridinium - toxicity 1-methyl-4-phenylpyridinium ion Animals apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - biosynthesis bcl-X Protein - biosynthesis Blotting, Western Carnitine - pharmacology Cell Nucleus - drug effects Cell Nucleus - ultrastructure Cells, Cultured Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Immunohistochemistry In Situ Nick-End Labeling l-carnitine L-Lactate Dehydrogenase - metabolism MPP neurodegeneration Neurology neuronal rescue Neurons - drug effects Neurons - pathology Neuroprotective Agents Prosencephalon - drug effects Prosencephalon - pathology Rats Rats, Sprague-Dawley Sialic Acids - metabolism Tetrazolium Salts Thiazoles
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