Identification of a novel competitive inhibitor of p38α MAPK by a human PBMC screen

The pro-inflammatory cytokines TNF-α and IL-1β are two of the important mediators involved in the several chronic inflammatory diseases. We used the release of TNF-α and IL-1β from lipopolysaccharide-stimulated human PBMC as inflammatory indexes to discover the potential anti-inflammatory candidates...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 2007-01, Vol.352 (3), p.656-661
Hauptverfasser:	Liu, Yu-Chih, Ko, Chia-Chen, Cheng, Fong-Chi, Huang, Po-Tsang, Lou, Kuo-Long, Chow, Lu-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokine IL-1β Inflammation Inhibitor p38α MAPK Peripheral blood mononuclear cell Screening TNF-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!