Inhibitory effects of water extract of propolis on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster
Propolis is a substance produced by honeybees ( Apis mellifera L.). Its components are strong antioxidants and free radical scavengers. The aim of this study was to evaluate the protective effects of a water extract of Brazilian green propolis (WEP) combined with the antitumor agent doxorubicin (DXR...
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| Veröffentlicht in: | Food and chemical toxicology 2008-03, Vol.46 (3), p.1103-1110 |
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| creator | Valadares, B.L.B. Graf, U. Spanó, M.A. |
| description | Propolis is a substance produced by honeybees (
Apis mellifera L.). Its components are strong antioxidants and free radical scavengers. The aim of this study was to evaluate the protective effects of a water extract of Brazilian green propolis (WEP) combined with the antitumor agent doxorubicin (DXR) on
Drosophila melanogaster wing cells through the somatic mutation and recombination test (SMART). Two different crosses were used: The standard (ST) cross and the high bioactivation (HB) cross. The HB cross is characterized by a constitutively enhanced level of cytochrome P450 which leads to an increased sensitivity to a number of promutagens and procarcinogens. Larvae obtained from these two crosses were chronically treated with different concentrations of WEP (12.5,
25.0 and 50.0
mg/mL) alone or combined with DXR (0.125
mg/mL). The results obtained with the two different crosses were rather similar. Neither toxicity nor genotoxicity were observed in WEP treated series. Simultaneous treatment with different concentrations of WEP and DXR led to a reduction in the frequency of recombination compared to the treatment with DXR alone. This anti-recombinogenic effect was proportional to the concentrations applied, indicating a dose–response correlation and can be attributed to the powerful scavenger ability of WEP. |
| doi_str_mv | 10.1016/j.fct.2007.11.005 |
| format | Article |
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Apis mellifera L.). Its components are strong antioxidants and free radical scavengers. The aim of this study was to evaluate the protective effects of a water extract of Brazilian green propolis (WEP) combined with the antitumor agent doxorubicin (DXR) on
Drosophila melanogaster wing cells through the somatic mutation and recombination test (SMART). Two different crosses were used: The standard (ST) cross and the high bioactivation (HB) cross. The HB cross is characterized by a constitutively enhanced level of cytochrome P450 which leads to an increased sensitivity to a number of promutagens and procarcinogens. Larvae obtained from these two crosses were chronically treated with different concentrations of WEP (12.5,
25.0 and 50.0
mg/mL) alone or combined with DXR (0.125
mg/mL). The results obtained with the two different crosses were rather similar. Neither toxicity nor genotoxicity were observed in WEP treated series. Simultaneous treatment with different concentrations of WEP and DXR led to a reduction in the frequency of recombination compared to the treatment with DXR alone. This anti-recombinogenic effect was proportional to the concentrations applied, indicating a dose–response correlation and can be attributed to the powerful scavenger ability of WEP.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2007.11.005</identifier><identifier>PMID: 18160198</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>animal models ; Animals ; Antigenotoxicity ; Antimutagenic Agents - pharmacology ; antioxidants ; Apis mellifera ; Biological and medical sciences ; Doxorubicin - toxicity ; Drosophila ; Drosophila melanogaster ; Drosophila melanogaster - genetics ; extracts ; free radical scavengers ; genetic recombination ; Genotoxicity ; larvae ; Medical sciences ; Mutation ; Propolis ; Propolis - chemistry ; protective effect ; Recombination, Genetic ; SMART ; Toxicology ; Water - chemistry ; Wing spot test</subject><ispartof>Food and chemical toxicology, 2008-03, Vol.46 (3), p.1103-1110</ispartof><rights>2007</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-448f5baf5d328cb6a934806e3a89298617cb23c57a4c387c09233c35d83291f73</citedby><cites>FETCH-LOGICAL-c436t-448f5baf5d328cb6a934806e3a89298617cb23c57a4c387c09233c35d83291f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2007.11.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20169490$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18160198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valadares, B.L.B.</creatorcontrib><creatorcontrib>Graf, U.</creatorcontrib><creatorcontrib>Spanó, M.A.</creatorcontrib><title>Inhibitory effects of water extract of propolis on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Propolis is a substance produced by honeybees (
Apis mellifera L.). Its components are strong antioxidants and free radical scavengers. The aim of this study was to evaluate the protective effects of a water extract of Brazilian green propolis (WEP) combined with the antitumor agent doxorubicin (DXR) on
Drosophila melanogaster wing cells through the somatic mutation and recombination test (SMART). Two different crosses were used: The standard (ST) cross and the high bioactivation (HB) cross. The HB cross is characterized by a constitutively enhanced level of cytochrome P450 which leads to an increased sensitivity to a number of promutagens and procarcinogens. Larvae obtained from these two crosses were chronically treated with different concentrations of WEP (12.5,
25.0 and 50.0
mg/mL) alone or combined with DXR (0.125
mg/mL). The results obtained with the two different crosses were rather similar. Neither toxicity nor genotoxicity were observed in WEP treated series. Simultaneous treatment with different concentrations of WEP and DXR led to a reduction in the frequency of recombination compared to the treatment with DXR alone. This anti-recombinogenic effect was proportional to the concentrations applied, indicating a dose–response correlation and can be attributed to the powerful scavenger ability of WEP.</description><subject>animal models</subject><subject>Animals</subject><subject>Antigenotoxicity</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>antioxidants</subject><subject>Apis mellifera</subject><subject>Biological and medical sciences</subject><subject>Doxorubicin - toxicity</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - genetics</subject><subject>extracts</subject><subject>free radical scavengers</subject><subject>genetic recombination</subject><subject>Genotoxicity</subject><subject>larvae</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Propolis</subject><subject>Propolis - chemistry</subject><subject>protective effect</subject><subject>Recombination, Genetic</subject><subject>SMART</subject><subject>Toxicology</subject><subject>Water - chemistry</subject><subject>Wing spot test</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQQC0EokvhB3CBXOCW4IkTxxanqnxVqsQBerYcx269SuzFdqC988OZVVZw4zTSzJvxzDMhL4E2QIG_2zfOlKaldGgAGkr7R2QHYmA1Zz08JjvaDqLmEvoz8iznPUUQBv6UnIEATkGKHfl9Fe786EtMD5V1zpqSq-iqX7rYVNn7krQpx8QhxUOcPRZDNcX7mNbRGx9qH6bV2KnKcdHFm2pZC0aEdJiqZE1cRh-2jA_VhxRzPNz5WVeLnXWItzrjQ8_JE6fnbF-c4jm5-fTx--WX-vrr56vLi-vadIyXuuuE60ft-om1woxcS9YJyi3TQrZScBjM2DLTD7ozTAyGypYxw_pJsFaCG9g5ebvNxWt-rDYXtfhs7Iyb2LhmBbJnlFFAEDbQ4MI5WacOyS86PSig6qhe7RWqV0f1CkCheux5dRq-joud_nWcXCPw5gTobPTskg7G579ci2NlJylyrzfO6aj0bULm5htWGaVCUso7JN5vhEVZP71NKhtvA_6DR-VFTdH_Z9E_qMasog</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Valadares, B.L.B.</creator><creator>Graf, U.</creator><creator>Spanó, M.A.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20080301</creationdate><title>Inhibitory effects of water extract of propolis on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster</title><author>Valadares, B.L.B. ; Graf, U. ; Spanó, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-448f5baf5d328cb6a934806e3a89298617cb23c57a4c387c09233c35d83291f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Antigenotoxicity</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>antioxidants</topic><topic>Apis mellifera</topic><topic>Biological and medical sciences</topic><topic>Doxorubicin - toxicity</topic><topic>Drosophila</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - genetics</topic><topic>extracts</topic><topic>free radical scavengers</topic><topic>genetic recombination</topic><topic>Genotoxicity</topic><topic>larvae</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Propolis</topic><topic>Propolis - chemistry</topic><topic>protective effect</topic><topic>Recombination, Genetic</topic><topic>SMART</topic><topic>Toxicology</topic><topic>Water - chemistry</topic><topic>Wing spot test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valadares, B.L.B.</creatorcontrib><creatorcontrib>Graf, U.</creatorcontrib><creatorcontrib>Spanó, M.A.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valadares, B.L.B.</au><au>Graf, U.</au><au>Spanó, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of water extract of propolis on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>46</volume><issue>3</issue><spage>1103</spage><epage>1110</epage><pages>1103-1110</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Propolis is a substance produced by honeybees (
Apis mellifera L.). Its components are strong antioxidants and free radical scavengers. The aim of this study was to evaluate the protective effects of a water extract of Brazilian green propolis (WEP) combined with the antitumor agent doxorubicin (DXR) on
Drosophila melanogaster wing cells through the somatic mutation and recombination test (SMART). Two different crosses were used: The standard (ST) cross and the high bioactivation (HB) cross. The HB cross is characterized by a constitutively enhanced level of cytochrome P450 which leads to an increased sensitivity to a number of promutagens and procarcinogens. Larvae obtained from these two crosses were chronically treated with different concentrations of WEP (12.5,
25.0 and 50.0
mg/mL) alone or combined with DXR (0.125
mg/mL). The results obtained with the two different crosses were rather similar. Neither toxicity nor genotoxicity were observed in WEP treated series. Simultaneous treatment with different concentrations of WEP and DXR led to a reduction in the frequency of recombination compared to the treatment with DXR alone. This anti-recombinogenic effect was proportional to the concentrations applied, indicating a dose–response correlation and can be attributed to the powerful scavenger ability of WEP.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>18160198</pmid><doi>10.1016/j.fct.2007.11.005</doi><tpages>8</tpages></addata></record> |
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| subjects | animal models Animals Antigenotoxicity Antimutagenic Agents - pharmacology antioxidants Apis mellifera Biological and medical sciences Doxorubicin - toxicity Drosophila Drosophila melanogaster Drosophila melanogaster - genetics extracts free radical scavengers genetic recombination Genotoxicity larvae Medical sciences Mutation Propolis Propolis - chemistry protective effect Recombination, Genetic SMART Toxicology Water - chemistry Wing spot test |
| title | Inhibitory effects of water extract of propolis on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster |
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