Antiseptic effects of dabrafenib on TGFBIp-induced septic responses

Transforming growth factor-β-induced protein (TGFBIp), an extracellular protein, is expressed on several cell types in response to TGF-β stimulation. Human umbilical vein endothelial cell (HUVEC)-derived TGFBIp functions as a mediator of sepsis. Screening of bioactive compound libraries is an effect...

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Veröffentlicht in:	Chemico-biological interactions 2017-12, Vol.278, p.92-100
Hauptverfasser:	Lee, In-Chul, Bae, Jong-Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - drug effects Cell Adhesion Molecules - metabolism Cell Movement - drug effects Cells, Cultured Dabrafenib Disease Models, Animal Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Extracellular Matrix Proteins - pharmacology Human Umbilical Vein Endothelial Cells Humans Imidazoles - pharmacology Imidazoles - therapeutic use Inflammation Leukocytes - cytology Leukocytes - drug effects Leukocytes - metabolism Lung - pathology Male Mice Mice, Inbred C57BL Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Oximes - pharmacology Oximes - therapeutic use p38 Mitogen-Activated Protein Kinases - metabolism Permeability - drug effects Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Sepsis Sepsis - drug therapy Sepsis - mortality Sepsis - pathology Survival Rate TGFBIp Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology
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