Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators

The RAW264.7 mouse macrophage cell line is used extensively to carry out in vitro screens for immunomodulators. Compounds that are effective at reducing the expression of pro-inflammatory cytokines or nitric oxide (NO) from lipopolysaccharide (LPS)-stimulated RAW264.7 cells are often considered cand...

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Veröffentlicht in:	Journal of immunological methods 2018-01, Vol.452, p.26-31
Hauptverfasser:	Elisia, Ingrid, Pae, Han Bee, Lam, Vivian, Cederberg, Rachel, Hofs, Elyse, Krystal, Gerald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism E. coli Humans Immunologic Factors - metabolism Immunomodulators Leukocytes, Mononuclear - immunology Macrophages - immunology Mice Nitric Oxide - metabolism PBMCs RAW 264.7 Cells RAW264.7 cells Reproducibility of Results Whole blood assays
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