The temporal response and mechanism of action of tranexamic acid in endothelial glycocalyx degradation

The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress-related sympathoadrenal activation, and inflammation. Tranexamic acid (TXA) may prevent GCX degradation. The ther...

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Veröffentlicht in:	The journal of trauma and acute care surgery 2018-01, Vol.84 (1), p.75-80
Hauptverfasser:	Diebel, Mark E, Martin, Jonathan V, Liberati, David M, Diebel, Lawrence N
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM17 Protein - metabolism Cell Culture Techniques Doxycycline - pharmacology Epinephrine Glycocalyx - drug effects Glycocalyx - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hyaluronic Acid Hydrogen Peroxide Oxidative Stress Protease Inhibitors - pharmacology Syndecan-1 - metabolism Time Factors Tranexamic Acid - pharmacology
Online-Zugang:	Volltext
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