Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin

Abstract Chronic arsenic exposure in humans is associated with cancers of the skin, lung, bladder and other tissues. There is evidence that folate deficiency may increase susceptibility to arsenic effects, including skin lesions. K6/ODC mice develop skin tumors when exposed to 10 ppm sodium arsenite...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 2007-11, Vol.241 (3), p.134-145
Hauptverfasser:	Nelson, Gail M, Ahlborn, Gene J, Delker, Don A, Kitchin, Kirk T, O’Brien, Thomas G, Chen, Yan, Kohan, Michael J, Roop, Barbara C, Ward, William O, Allen, James W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenites - toxicity Binding Sites Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens, Environmental - toxicity Cell Differentiation - drug effects Cell Proliferation - drug effects Chemical agents Chemical and industrial products toxicology. Toxic occupational diseases Emergency Epidermal differentiation Epidermis - drug effects Epidermis - metabolism Female Folate deficiency Folic Acid - administration & dosage Folic Acid - blood Folic Acid Deficiency - genetics Folic Acid Deficiency - metabolism Gene expression Gene Expression - drug effects Gene Expression Profiling Homocysteine - blood Medical sciences Metals and various inorganic compounds Mice Mice, Transgenic ODC transgenic mouse Oligonucleotide Array Sequence Analysis Skin Skin - drug effects Skin - metabolism Skin Neoplasms - genetics Skin Neoplasms - metabolism Sodium arsenite Sodium Compounds - toxicity Toxicology Transcription Factors - metabolism Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!