Dihydroxy-, Hydroxyspirolactone-, and Dihydroxyspirolactone-urochlorins Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Liver of Mice

Previous work has shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes porphyria, enhanced by iron, in C57BL/6J mice with marked accumulation in the liver of uroporphyrin I and III isomers and heptacarboxylic acid III and is one model of human porphyria cutanea tarda. Preliminary examination...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical research in toxicology 2006-12, Vol.19 (12), p.1660-1667
Hauptverfasser:	Lim, Chang-Kee, Danton, Malcolm, Clothier, Bruce, Smith, Andrew G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, High Pressure Liquid Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL Molecular Structure Oxidation-Reduction Polychlorinated Dibenzodioxins - toxicity Spectrometry, Mass, Electrospray Ionization Spironolactone - metabolism Tandem Mass Spectrometry Uroporphyrinogens - metabolism Uroporphyrins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!