Nature of allelic sequence polymorphism at the KIR3DL3 locus

KIR3DL3 is a framework gene of the Leukocyte Receptor Complex, present in all individuals and haplotypes analysed to date. We describe 17 novel KIR3DL3 alleles, including seven single nucleotide polymorphic (SNP) positions within the coding region. Sequence variation within introns included a VNTR w...

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Veröffentlicht in:	Immunogenetics (New York) 2006-08, Vol.58 (8), p.614-627
Hauptverfasser:	Jones, Des C, Hiby, Susan E, Moffett, Ashley, Trowsdale, John, Young, Neil T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Case-Control Studies Cohort Studies Decidua Female Gene Frequency Gene polymorphism Genetic Variation Genetics Haplotypes Humans Immunoglobulins Introns Killer cell immunoglobulin-like receptors Killer Cells, Natural - immunology KIR protein Leukocytes Linkage analysis Linkage Disequilibrium Loci mRNA Mutation Nucleotides Pan troglodytes Phylogeny Polymorphism Polymorphism, Single Nucleotide - genetics Positive selection Potassium channels (inwardly-rectifying) Pre-eclampsia Pre-Eclampsia - genetics Pre-Eclampsia - immunology Pregnancy Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, KIR Receptors, KIR2DL3 Recombination Recombination, Genetic Selection, Genetic Single-nucleotide polymorphism
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