Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody–drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study

Antibody–drug conjugates have emerged as a powerful strategy in cancer therapy and combine the ability of monoclonal antibodies to specifically target tumour cells with the highly potent killing activity of drugs with payloads too toxic for systemic administration. Trastuzumab deruxtecan (also known...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The lancet oncology 2017-11, Vol.18 (11), p.1512-1522
Hauptverfasser:	Doi, Toshihiko, Shitara, Kohei, Naito, Yoichi, Shimomura, Akihiko, Fujiwara, Yasuhiro, Yonemori, Kan, Shimizu, Chikako, Shimoi, Tatsunori, Kuboki, Yasutoshi, Matsubara, Nobuaki, Kitano, Atsuko, Jikoh, Takahiro, Lee, Caleb, Fujisaki, Yoshihiko, Ogitani, Yusuke, Yver, Antoine, Tamura, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - surgery Cancer therapies Chemotherapy, Adjuvant Clinical trials Cytotoxicity Disease-Free Survival Dose-Response Relationship, Drug Drug Administration Schedule Drug dosages Epidermal growth factor ErbB-2 protein Esophageal cancer Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophagus Female Gastric cancer Humans Immunoconjugates - therapeutic use Immunotherapy Japan Kaplan-Meier Estimate Male Mastectomy - methods Maximum Tolerated Dose Medical prognosis Metastasis Middle Aged Monoclonal antibodies Neoplasm Invasiveness - pathology Neoplasm Staging Patient Safety Patients Pharmacokinetics Prognosis Proteins Receptor, ErbB-2 - drug effects Receptor, ErbB-2 - genetics Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - pathology Survival Analysis Targeted cancer therapy Trastuzumab Trastuzumab - adverse effects Trastuzumab - pharmacokinetics Trastuzumab - therapeutic use Treatment Outcome Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!