Chemokine CCL8 and its receptor CCR5 in the spinal cord are involved in visceral pain induced by experimental colitis in mice

•TNBS induced visceral pain and the upregulation of spinal CCL8 and CCR5 in mice.•CCL8 and CCR5 were expressed by neurons in the spinal dorsal horn after TNBS.•Inhibition of CCL8 or CCR5 attenuated pain by reducing spinal pERK expression. Visceral hypersensitivity induced by inﬂammatory bowel diseas...

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Veröffentlicht in:	Brain research bulletin 2017-10, Vol.135, p.170-178
Hauptverfasser:	Lu, Ying, Jiang, Bao-Chun, Cao, De-Li, Zhao, Lin-Xia, Zhang, You-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCL8 CCR5 Chemokine CCL8 - metabolism Chemokine CCL8 - physiology Colitis - chemically induced Colitis - physiopathology Disease Models, Animal ERK Gene Expression Regulation - genetics Hyperalgesia - metabolism Hyperalgesia - pathology Male Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Neuralgia - metabolism Neurons - metabolism Receptors, CCR5 - metabolism Receptors, CCR5 - physiology Spinal cord Spinal Cord - metabolism Spinal Cord - physiopathology Up-Regulation Visceral hypersensitivity Visceral Pain - metabolism Visceral Pain - physiopathology
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