Graphene Liquid Enclosure for Single-Molecule Analysis of Membrane Proteins in Whole Cells Using Electron Microscopy

Membrane proteins govern many important functions in cells via dynamic oligomerization into active complexes. However, analytical methods to study their distribution and functional state in relation to the cellular structure are currently limited. Here, we introduce a technique for studying single-m...

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Veröffentlicht in:	ACS nano 2017-11, Vol.11 (11), p.11108-11117
Hauptverfasser:	Dahmke, Indra N, Verch, Andreas, Hermannsdörfer, Justus, Peckys, Diana B, Weatherup, Robert S, Hofmann, Stephan, de Jonge, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Graphite - chemistry Humans Lab-On-A-Chip Devices Membrane Proteins - chemistry Microscopy, Electron Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - isolation & purification Quantum Dots - chemistry Receptor, ErbB-2 - chemistry Receptor, ErbB-2 - genetics Silicon Compounds - chemistry Single Molecule Imaging - methods
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