Fibrinogen cleavage products and Toll-like receptor 4 promote the generation of programmed cell death 1 ligand 2–positive dendritic cells in allergic asthma

Inhaled protease allergens preferentially trigger TH2-mediated inflammation in allergic asthma. The role of dendritic cells (DCs) on induction of TH2 cell responses in allergic asthma has been well documented; however, the mechanism by which protease allergens induce TH2-favorable DCs in the airway...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2018-08, Vol.142 (2), p.530-541.e6
Hauptverfasser:	Cho, Minkyoung, Lee, Jeong-Eun, Lim, Hoyong, Shin, Hyun-Woo, Khalmuratova, Roza, Choi, Garam, Kim, Hyuk Soon, Choi, Wahn Soo, Park, Young-Jun, Shim, Inbo, Kim, Byung-Seok, Kang, Chang-Yuil, Kim, Jae-Ouk, Tanaka, Shinya, Kubo, Masato, Tung, Hui-Ying, Landers, Cameron T., Corry, David B., Kheradmand, Farrah, Chung, Yeonseok
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Allergens - immunology Allergies Animals Antigens Apoptosis Asthma Asthma - immunology Bone marrow Cell culture Cell death Cell Differentiation Cleavage Cytokines Dendritic cells Dendritic Cells - immunology Disease Models, Animal Experiments Fibrinogen Fibrinogen - immunology Fibrinogen - metabolism fibrinogen cleavage product Helper cells Histamine Humans Hypersensitivity Hypersensitivity - immunology Immunity, Innate Inflammation Interleukin 13 Interleukin-13 - metabolism Intranasal administration Laboratory animals Ligands Lungs Lymph nodes Lymphocyte Activation Lymphocytes Lymphocytes T Lymphoid cells mast cell Mast cells Mice Mice, Inbred C57BL Mice, Knockout PD-1 protein PD-L2+ dendritic cells Peptide Fragments - immunology Peptide Fragments - metabolism Peptide Hydrolases - metabolism Phenotypes Population Programmed Cell Death 1 Ligand 2 Protein - metabolism Protease Protease allergen Proteinase Respiratory tract Respiratory tract diseases Studies Th2 Cells - immunology TLR4 protein Toll-like receptor 4 Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors
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