Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment
Abstract Objective This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain. Methods A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles wer...
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| Veröffentlicht in: | Pain medicine (Malden, Mass.) Mass.), 2018-04, Vol.19 (4), p.708-734 |
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| container_title | Pain medicine (Malden, Mass.) |
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| creator | Morgan, Michael Deuis, Jennifer R Frøsig-Jørgensen, Majbrit Lewis, Richard J Cabot, Peter J Gray, Paul D Vetter, Irina |
| description | Abstract
Objective
This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain.
Methods
A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain.
Results
The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes. The search on the treatment of burn pain yielded a total of 213 publications, 14 of which fit the inclusion/exclusion criteria, highlighting the limited amount of evidence available on the treatment of burn-induced pain.
Conclusions
The pathophysiology of burn pain is poorly understood, with limited clinical trials available to assess the effectiveness of analgesics in burn patients. Further studies are needed to identify new pharmacological targets and treatments for the effective management of burn injury pain. |
| doi_str_mv | 10.1093/pm/pnx228 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1952107976</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A588341779</galeid><oup_id>10.1093/pm/pnx228</oup_id><sourcerecordid>A588341779</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-1915ec34c889ea6091e407926da15ea785eb4b8b3997d6f24edac75c9957c6fe3</originalsourceid><addsrcrecordid>eNp9kVtr3DAQhUVpyLUP_QPF0D6kkM3qZsnq22bZXCCQ0G6f8iC08jhRsC1HstPuv6-W3TQkhKAHDTPfOQxzEPpM8DHBio27Zty1fyktPqBdklMx4oLJj5uaMpnvoL0Y7zEmghdsG-1QhZngQu2im5MhtNm1ce2PbJL9WsYeGtM7m5m2zKbBpdLU2U94dPAn81U261wJjfO1v10eJV1_57u7ZXxqrFTzAKZvoO0P0FZl6gifNv8--n06m0_PR5dXZxfTyeXIcon7EVEkB8u4LQoFRmBFgGOpqChNGhhZ5LDgi2LBlJKlqCiH0liZW6VyaUUFbB8drn274B8GiL1uXLRQ16YFP0RNVE5JcpQioV9fofc-HSBtpymhkkmeDvNM3ZoatGsr3wdjV6Z6khcF40RKlajjN6j0VgeyvoXKpf4Lwfe1wAYfY4BKd8E1Jiw1wXoVpO4avQ4ysV82iw6LBsr_5FNyCfi2BvzQvePzD8_uo0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2127374036</pqid></control><display><type>article</type><title>Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Morgan, Michael ; Deuis, Jennifer R ; Frøsig-Jørgensen, Majbrit ; Lewis, Richard J ; Cabot, Peter J ; Gray, Paul D ; Vetter, Irina</creator><creatorcontrib>Morgan, Michael ; Deuis, Jennifer R ; Frøsig-Jørgensen, Majbrit ; Lewis, Richard J ; Cabot, Peter J ; Gray, Paul D ; Vetter, Irina</creatorcontrib><description>Abstract
Objective
This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain.
Methods
A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain.
Results
The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes. The search on the treatment of burn pain yielded a total of 213 publications, 14 of which fit the inclusion/exclusion criteria, highlighting the limited amount of evidence available on the treatment of burn-induced pain.
Conclusions
The pathophysiology of burn pain is poorly understood, with limited clinical trials available to assess the effectiveness of analgesics in burn patients. Further studies are needed to identify new pharmacological targets and treatments for the effective management of burn injury pain.</description><identifier>ISSN: 1526-2375</identifier><identifier>EISSN: 1526-4637</identifier><identifier>DOI: 10.1093/pm/pnx228</identifier><identifier>PMID: 29036469</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Analgesia ; Analgesics ; Analysis ; Animal models ; Burn patients ; Burns ; Burns - complications ; Care and treatment ; Clinical trials ; Epidemiology ; Evidence-based medicine ; Humans ; Medical research ; Pain ; Pain - epidemiology ; Pain - etiology ; Pain - physiopathology ; Pain management ; Pain Management - methods</subject><ispartof>Pain medicine (Malden, Mass.), 2018-04, Vol.19 (4), p.708-734</ispartof><rights>2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2017</rights><rights>COPYRIGHT 2018 Oxford University Press</rights><rights>Copyright © 2017 American Academy of Pain Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1915ec34c889ea6091e407926da15ea785eb4b8b3997d6f24edac75c9957c6fe3</citedby><cites>FETCH-LOGICAL-c470t-1915ec34c889ea6091e407926da15ea785eb4b8b3997d6f24edac75c9957c6fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1583,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29036469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morgan, Michael</creatorcontrib><creatorcontrib>Deuis, Jennifer R</creatorcontrib><creatorcontrib>Frøsig-Jørgensen, Majbrit</creatorcontrib><creatorcontrib>Lewis, Richard J</creatorcontrib><creatorcontrib>Cabot, Peter J</creatorcontrib><creatorcontrib>Gray, Paul D</creatorcontrib><creatorcontrib>Vetter, Irina</creatorcontrib><title>Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment</title><title>Pain medicine (Malden, Mass.)</title><addtitle>Pain Med</addtitle><description>Abstract
Objective
This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain.
Methods
A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain.
Results
The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes. The search on the treatment of burn pain yielded a total of 213 publications, 14 of which fit the inclusion/exclusion criteria, highlighting the limited amount of evidence available on the treatment of burn-induced pain.
Conclusions
The pathophysiology of burn pain is poorly understood, with limited clinical trials available to assess the effectiveness of analgesics in burn patients. Further studies are needed to identify new pharmacological targets and treatments for the effective management of burn injury pain.</description><subject>Analgesia</subject><subject>Analgesics</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Burn patients</subject><subject>Burns</subject><subject>Burns - complications</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Epidemiology</subject><subject>Evidence-based medicine</subject><subject>Humans</subject><subject>Medical research</subject><subject>Pain</subject><subject>Pain - epidemiology</subject><subject>Pain - etiology</subject><subject>Pain - physiopathology</subject><subject>Pain management</subject><subject>Pain Management - methods</subject><issn>1526-2375</issn><issn>1526-4637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kVtr3DAQhUVpyLUP_QPF0D6kkM3qZsnq22bZXCCQ0G6f8iC08jhRsC1HstPuv6-W3TQkhKAHDTPfOQxzEPpM8DHBio27Zty1fyktPqBdklMx4oLJj5uaMpnvoL0Y7zEmghdsG-1QhZngQu2im5MhtNm1ce2PbJL9WsYeGtM7m5m2zKbBpdLU2U94dPAn81U261wJjfO1v10eJV1_57u7ZXxqrFTzAKZvoO0P0FZl6gifNv8--n06m0_PR5dXZxfTyeXIcon7EVEkB8u4LQoFRmBFgGOpqChNGhhZ5LDgi2LBlJKlqCiH0liZW6VyaUUFbB8drn274B8GiL1uXLRQ16YFP0RNVE5JcpQioV9fofc-HSBtpymhkkmeDvNM3ZoatGsr3wdjV6Z6khcF40RKlajjN6j0VgeyvoXKpf4Lwfe1wAYfY4BKd8E1Jiw1wXoVpO4avQ4ysV82iw6LBsr_5FNyCfi2BvzQvePzD8_uo0g</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Morgan, Michael</creator><creator>Deuis, Jennifer R</creator><creator>Frøsig-Jørgensen, Majbrit</creator><creator>Lewis, Richard J</creator><creator>Cabot, Peter J</creator><creator>Gray, Paul D</creator><creator>Vetter, Irina</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment</title><author>Morgan, Michael ; Deuis, Jennifer R ; Frøsig-Jørgensen, Majbrit ; Lewis, Richard J ; Cabot, Peter J ; Gray, Paul D ; Vetter, Irina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-1915ec34c889ea6091e407926da15ea785eb4b8b3997d6f24edac75c9957c6fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analgesia</topic><topic>Analgesics</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Burn patients</topic><topic>Burns</topic><topic>Burns - complications</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Epidemiology</topic><topic>Evidence-based medicine</topic><topic>Humans</topic><topic>Medical research</topic><topic>Pain</topic><topic>Pain - epidemiology</topic><topic>Pain - etiology</topic><topic>Pain - physiopathology</topic><topic>Pain management</topic><topic>Pain Management - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morgan, Michael</creatorcontrib><creatorcontrib>Deuis, Jennifer R</creatorcontrib><creatorcontrib>Frøsig-Jørgensen, Majbrit</creatorcontrib><creatorcontrib>Lewis, Richard J</creatorcontrib><creatorcontrib>Cabot, Peter J</creatorcontrib><creatorcontrib>Gray, Paul D</creatorcontrib><creatorcontrib>Vetter, Irina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Pain medicine (Malden, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morgan, Michael</au><au>Deuis, Jennifer R</au><au>Frøsig-Jørgensen, Majbrit</au><au>Lewis, Richard J</au><au>Cabot, Peter J</au><au>Gray, Paul D</au><au>Vetter, Irina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment</atitle><jtitle>Pain medicine (Malden, Mass.)</jtitle><addtitle>Pain Med</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>19</volume><issue>4</issue><spage>708</spage><epage>734</epage><pages>708-734</pages><issn>1526-2375</issn><eissn>1526-4637</eissn><abstract>Abstract
Objective
This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain.
Methods
A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain.
Results
The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes. The search on the treatment of burn pain yielded a total of 213 publications, 14 of which fit the inclusion/exclusion criteria, highlighting the limited amount of evidence available on the treatment of burn-induced pain.
Conclusions
The pathophysiology of burn pain is poorly understood, with limited clinical trials available to assess the effectiveness of analgesics in burn patients. Further studies are needed to identify new pharmacological targets and treatments for the effective management of burn injury pain.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29036469</pmid><doi>10.1093/pm/pnx228</doi><tpages>27</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pain medicine (Malden, Mass.), 2018-04, Vol.19 (4), p.708-734 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Analgesia Analgesics Analysis Animal models Burn patients Burns Burns - complications Care and treatment Clinical trials Epidemiology Evidence-based medicine Humans Medical research Pain Pain - epidemiology Pain - etiology Pain - physiopathology Pain management Pain Management - methods |
| title | Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment |
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