Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia
Perturbation of corticohippocampal circuits is a key step in the pathogenesis of transient global amnesia. We evaluated the spatial distribution of altered cerebral metabolism to determine the location of the corticohippocampal circuits perturbed during the acute stage of transient global amnesia. A...
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| Veröffentlicht in: | Brain topography 2018-05, Vol.31 (3), p.468-476 |
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| creator | Yi, SangHak Park, Young Ho Jang, Jae-Won Lim, Jae-Sung Chun, In Kook Kim, SangYun |
| description | Perturbation of corticohippocampal circuits is a key step in the pathogenesis of transient global amnesia. We evaluated the spatial distribution of altered cerebral metabolism to determine the location of the corticohippocampal circuits perturbed during the acute stage of transient global amnesia. A consecutive series of 12 patients with transient global amnesia who underwent
18
F-fluorodeoxyglucose positron emission tomography within 3 days after symptom onset was identified. We used statistical parametric mapping with two contrasts to identify regions of decreased and increased brain metabolism in transient global amnesia patients compared with 25 age-matched controls. Transient global amnesia patients showed hypometabolic clusters in the left temporal and bilateral parieto-occipital regions that belong to the posterior medial network as well as, hypermetabolic clusters in the bilateral inferior frontal regions that belong to the anterior temporal network. The posterior medial and anterior temporal networks are the two main corticohippocampal circuits involved in memory-guided behavior. Decreased metabolism in the posterior medial network might explain the impairment of episodic memory observed during the acute stage of transient global amnesia. Concomitant increased metabolism within the anterior temporal network might occur as a compensatory mechanism. |
| doi_str_mv | 10.1007/s10548-017-0602-y |
| format | Article |
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18
F-fluorodeoxyglucose positron emission tomography within 3 days after symptom onset was identified. We used statistical parametric mapping with two contrasts to identify regions of decreased and increased brain metabolism in transient global amnesia patients compared with 25 age-matched controls. Transient global amnesia patients showed hypometabolic clusters in the left temporal and bilateral parieto-occipital regions that belong to the posterior medial network as well as, hypermetabolic clusters in the bilateral inferior frontal regions that belong to the anterior temporal network. The posterior medial and anterior temporal networks are the two main corticohippocampal circuits involved in memory-guided behavior. Decreased metabolism in the posterior medial network might explain the impairment of episodic memory observed during the acute stage of transient global amnesia. Concomitant increased metabolism within the anterior temporal network might occur as a compensatory mechanism.</description><identifier>ISSN: 0896-0267</identifier><identifier>EISSN: 1573-6792</identifier><identifier>DOI: 10.1007/s10548-017-0602-y</identifier><identifier>PMID: 29038979</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Amnesia ; Amnesia, Transient Global - diagnostic imaging ; Amnesia, Transient Global - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Brain - diagnostic imaging ; Brain - metabolism ; Brain mapping ; Circuits ; Female ; Glucose - metabolism ; Humans ; Male ; Memory, Episodic ; Metabolism ; Middle Aged ; Neurology ; Neurosciences ; Original Paper ; Positron emission tomography ; Psychiatry ; Spatial distribution</subject><ispartof>Brain topography, 2018-05, Vol.31 (3), p.468-476</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Brain Topography is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ba6756a55eaf7f9048b31ae03b01efc7b865710da639eccc8439b2679503a2733</citedby><cites>FETCH-LOGICAL-c372t-ba6756a55eaf7f9048b31ae03b01efc7b865710da639eccc8439b2679503a2733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10548-017-0602-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10548-017-0602-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29038979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yi, SangHak</creatorcontrib><creatorcontrib>Park, Young Ho</creatorcontrib><creatorcontrib>Jang, Jae-Won</creatorcontrib><creatorcontrib>Lim, Jae-Sung</creatorcontrib><creatorcontrib>Chun, In Kook</creatorcontrib><creatorcontrib>Kim, SangYun</creatorcontrib><title>Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia</title><title>Brain topography</title><addtitle>Brain Topogr</addtitle><addtitle>Brain Topogr</addtitle><description>Perturbation of corticohippocampal circuits is a key step in the pathogenesis of transient global amnesia. We evaluated the spatial distribution of altered cerebral metabolism to determine the location of the corticohippocampal circuits perturbed during the acute stage of transient global amnesia. A consecutive series of 12 patients with transient global amnesia who underwent
18
F-fluorodeoxyglucose positron emission tomography within 3 days after symptom onset was identified. We used statistical parametric mapping with two contrasts to identify regions of decreased and increased brain metabolism in transient global amnesia patients compared with 25 age-matched controls. Transient global amnesia patients showed hypometabolic clusters in the left temporal and bilateral parieto-occipital regions that belong to the posterior medial network as well as, hypermetabolic clusters in the bilateral inferior frontal regions that belong to the anterior temporal network. The posterior medial and anterior temporal networks are the two main corticohippocampal circuits involved in memory-guided behavior. Decreased metabolism in the posterior medial network might explain the impairment of episodic memory observed during the acute stage of transient global amnesia. Concomitant increased metabolism within the anterior temporal network might occur as a compensatory mechanism.</description><subject>Aged</subject><subject>Amnesia</subject><subject>Amnesia, Transient Global - diagnostic imaging</subject><subject>Amnesia, Transient Global - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain mapping</subject><subject>Circuits</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Memory, Episodic</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Positron emission tomography</subject><subject>Psychiatry</subject><subject>Spatial distribution</subject><issn>0896-0267</issn><issn>1573-6792</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1vEzEQhi0EoqHwA7ggS1y4LIzt2F4fo7SUSuXjEM6W15mlLrt2sL2q8mP4r2yU8CGknuYwzzwzmpeQlwzeMgD9rjCQy7YBphtQwJv9I7JgUotGacMfkwW0RjXAlT4jz0q5AwBhtH5KzrgB0RptFuTnBfqMruCWfsTqujSEMtIQab1F-iWVijmkPPe2wQ30E9b7lL_T-1Bv6TpFn8ZQXazDnl7Hhz2reNJscNyl_I_oYsohfqOb7GIJGCu9GlI391djxBLcc_Kkd0PBF6d6Tr6-v9ysPzQ3n6-u16ubxgvNa9M5paVyUqLrdW9g2XaCOQTRAcPe665VUjPYOiUMeu_bpTDd_BYjQTiuhTgnb47eXU4_JizVjqF4HAYXMU3FMiM5GCPkAX39H3qXphzn6ywHznWrl1LNFDtSPqdSMvZ2l8Po8t4ysIfs7DE7O2dnD9nZ_Tzz6mSeuhG3fyZ-hzUD_AiU3eFrmP-uftj6C0yepx4</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Yi, SangHak</creator><creator>Park, Young Ho</creator><creator>Jang, Jae-Won</creator><creator>Lim, Jae-Sung</creator><creator>Chun, In Kook</creator><creator>Kim, SangYun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia</title><author>Yi, SangHak ; Park, Young Ho ; Jang, Jae-Won ; Lim, Jae-Sung ; Chun, In Kook ; Kim, SangYun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ba6756a55eaf7f9048b31ae03b01efc7b865710da639eccc8439b2679503a2733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Amnesia</topic><topic>Amnesia, Transient Global - diagnostic imaging</topic><topic>Amnesia, Transient Global - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain mapping</topic><topic>Circuits</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Memory, Episodic</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Positron emission tomography</topic><topic>Psychiatry</topic><topic>Spatial distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yi, SangHak</creatorcontrib><creatorcontrib>Park, Young Ho</creatorcontrib><creatorcontrib>Jang, Jae-Won</creatorcontrib><creatorcontrib>Lim, Jae-Sung</creatorcontrib><creatorcontrib>Chun, In Kook</creatorcontrib><creatorcontrib>Kim, SangYun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain topography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yi, SangHak</au><au>Park, Young Ho</au><au>Jang, Jae-Won</au><au>Lim, Jae-Sung</au><au>Chun, In Kook</au><au>Kim, SangYun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia</atitle><jtitle>Brain topography</jtitle><stitle>Brain Topogr</stitle><addtitle>Brain Topogr</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>31</volume><issue>3</issue><spage>468</spage><epage>476</epage><pages>468-476</pages><issn>0896-0267</issn><eissn>1573-6792</eissn><abstract>Perturbation of corticohippocampal circuits is a key step in the pathogenesis of transient global amnesia. We evaluated the spatial distribution of altered cerebral metabolism to determine the location of the corticohippocampal circuits perturbed during the acute stage of transient global amnesia. A consecutive series of 12 patients with transient global amnesia who underwent
18
F-fluorodeoxyglucose positron emission tomography within 3 days after symptom onset was identified. We used statistical parametric mapping with two contrasts to identify regions of decreased and increased brain metabolism in transient global amnesia patients compared with 25 age-matched controls. Transient global amnesia patients showed hypometabolic clusters in the left temporal and bilateral parieto-occipital regions that belong to the posterior medial network as well as, hypermetabolic clusters in the bilateral inferior frontal regions that belong to the anterior temporal network. The posterior medial and anterior temporal networks are the two main corticohippocampal circuits involved in memory-guided behavior. Decreased metabolism in the posterior medial network might explain the impairment of episodic memory observed during the acute stage of transient global amnesia. Concomitant increased metabolism within the anterior temporal network might occur as a compensatory mechanism.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29038979</pmid><doi>10.1007/s10548-017-0602-y</doi><tpages>9</tpages></addata></record> |
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| ispartof | Brain topography, 2018-05, Vol.31 (3), p.468-476 |
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| subjects | Aged Amnesia Amnesia, Transient Global - diagnostic imaging Amnesia, Transient Global - metabolism Biomedical and Life Sciences Biomedicine Brain - diagnostic imaging Brain - metabolism Brain mapping Circuits Female Glucose - metabolism Humans Male Memory, Episodic Metabolism Middle Aged Neurology Neurosciences Original Paper Positron emission tomography Psychiatry Spatial distribution |
| title | Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia |
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