Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1

Curcumol, a polyphenol compound derived from the rhizome of Curcuma, has been established as an antitumor compound against multiple types of cancer, including gastric (GC), lung, liver and breast cancer. However, the molecular mechanisms undelying its anticancer activity in GC are still unclear. In...

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Veröffentlicht in:	Oncology reports 2017-12, Vol.38 (6), p.3583-3591
Hauptverfasser:	Zang, Shilei, Tang, Qiling, Dong, Fangrui, Liu, Huan, Li, Lili, Guo, Fang, Pan, Xuediao, Lin, Haorong, Zeng, Weibin, Cai, Zhaoxu, Zhong, Qibin, Zang, Ning, Zang, Linquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Alcohol Apoptosis Apoptosis - drug effects Breast cancer Cancer therapies Care and treatment Cell cycle Cell Cycle - drug effects Cell growth Cell Line, Tumor Cell Proliferation - drug effects curcumol Dehydrogenases Development and progression Enzymes Gastric cancer Gene Expression Regulation, Neoplastic - drug effects Genetic regulation Health aspects Humans isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Membrane Potential, Mitochondrial - drug effects mitochondrial membrane potential Oxidoreductases Polyphenols R&D reactive oxygen Reactive oxygen species Reactive Oxygen Species - metabolism Research & development Sesquiterpenes - administration & dosage Stomach cancer Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology
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