Oxadiazole mannich bases: Synthesis and antimycobacterial activity

A series of oxadiazole mannich bases were synthesized by reacting oxadiazole derivatives, dapsone and appropriate aldehyde in the presence of methanol. The synthesized compounds were evaluated for antimycobacterial activity against Mycobacterium tuberculosis H 37Rv and INH resistant M. tuberculosis....

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (12), p.3314-3316
Hauptverfasser:	Ali, Mohamed Ashraf, Shaharyar, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimycobacterial activity Biological and medical sciences Dapsone Dapsone - chemistry Drug Resistance, Bacterial Isoniazid Mannich bases Mannich Bases - chemical synthesis Mannich Bases - pharmacology Medical sciences Methanol - chemistry Microbial Sensitivity Tests Models, Chemical Molecular Structure Mycobacterium Mycobacterium tuberculosis - drug effects Oxadiazole Oxadiazoles - chemistry Pharmacology. Drug treatments
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