Vitamin K, circulating cytokines, and bone mineral density in older men and women
BACKGROUND: Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro. OBJECTIVE: The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated...
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| Veröffentlicht in: | The American journal of clinical nutrition 2008-08, Vol.88 (2), p.356-363 |
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| creator | Shea, M. Kyla Dallal, Gerard E Dawson-Hughes, Bess Ordovas, José M O'Donnell, Christopher J Gundberg, Caren M Peterson, James W Booth, Sarah L |
| description | BACKGROUND: Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro. OBJECTIVE: The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein (CRP) concentrations and 2) the effect of daily 500 μg phylloquinone supplementation for 3 y on cytokine concentrations. DESIGN: Concentrations of IL-6, osteoprotegerin, and CRP and bone mineral density (BMD) were measured at baseline and after 3 y of follow-up in 379 healthy men and women (60-81 y; 58.5% women) participating in a randomized trial that studied the effect of vitamin K supplementation on bone loss. RESULTS: Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6. Osteoprotegerin was associated positively with plasma phylloquinone and inversely with %ucOC. No differences were observed in the 3-y change in IL-6, osteoprotegerin, and CRP concentrations between participants who received phylloquinone supplementation and those who did not. Overall, no association was observed between the 3-y changes in circulating cytokines and BMD. CONCLUSIONS: Poor vitamin K status was associated with high concentrations of cytokines involved in bone turnover, but vitamin K supplementation did not confer a decrease in cytokine concentrations. The healthy status of this cohort may explain a lack of effect of vitamin K supplementation on cytokine concentrations. This trial was registered with www.clinicaltrials.gov as NCT00183001. |
| doi_str_mv | 10.1093/ajcn/88.2.356 |
| format | Article |
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Kyla ; Dallal, Gerard E ; Dawson-Hughes, Bess ; Ordovas, José M ; O'Donnell, Christopher J ; Gundberg, Caren M ; Peterson, James W ; Booth, Sarah L</creator><creatorcontrib>Shea, M. Kyla ; Dallal, Gerard E ; Dawson-Hughes, Bess ; Ordovas, José M ; O'Donnell, Christopher J ; Gundberg, Caren M ; Peterson, James W ; Booth, Sarah L</creatorcontrib><description>BACKGROUND: Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro. OBJECTIVE: The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein (CRP) concentrations and 2) the effect of daily 500 μg phylloquinone supplementation for 3 y on cytokine concentrations. DESIGN: Concentrations of IL-6, osteoprotegerin, and CRP and bone mineral density (BMD) were measured at baseline and after 3 y of follow-up in 379 healthy men and women (60-81 y; 58.5% women) participating in a randomized trial that studied the effect of vitamin K supplementation on bone loss. RESULTS: Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6. Osteoprotegerin was associated positively with plasma phylloquinone and inversely with %ucOC. No differences were observed in the 3-y change in IL-6, osteoprotegerin, and CRP concentrations between participants who received phylloquinone supplementation and those who did not. Overall, no association was observed between the 3-y changes in circulating cytokines and BMD. CONCLUSIONS: Poor vitamin K status was associated with high concentrations of cytokines involved in bone turnover, but vitamin K supplementation did not confer a decrease in cytokine concentrations. The healthy status of this cohort may explain a lack of effect of vitamin K supplementation on cytokine concentrations. This trial was registered with www.clinicaltrials.gov as NCT00183001.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/88.2.356</identifier><identifier>PMID: 18689371</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Aged ; Aged, 80 and over ; Area Under Curve ; Biological and medical sciences ; bone density ; Bone Density - drug effects ; Bone Density - physiology ; bone metabolism ; Bones ; C-Reactive Protein - metabolism ; Clinical trials ; Cytokines ; Cytokines - biosynthesis ; Cytokines - blood ; Dietary Supplements ; Double-Blind Method ; elderly ; elderly nutrition ; Feeding. Feeding behavior ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Health Status ; Humans ; in vitro studies ; interleukin-6 ; Interleukin-6 - biosynthesis ; Interleukin-6 - blood ; Male ; men ; Middle Aged ; Nutritional Status ; osteoprotegerin ; Osteoprotegerin - blood ; Osteoprotegerin - metabolism ; phylloquinone ; Proteins ; randomized clinical trials ; Studies ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin K ; Vitamin K - blood ; Vitamin K - metabolism ; Vitamin K 1 - administration & dosage ; vitamin supplements ; Vitamins ; women</subject><ispartof>The American journal of clinical nutrition, 2008-08, Vol.88 (2), p.356-363</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Aug 1, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-6c390e63ff5f44001c45816ce0f9cbae89930dae39738802efcfa8c09c8bc603</citedby><cites>FETCH-LOGICAL-c442t-6c390e63ff5f44001c45816ce0f9cbae89930dae39738802efcfa8c09c8bc603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20590858$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18689371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shea, M. Kyla</creatorcontrib><creatorcontrib>Dallal, Gerard E</creatorcontrib><creatorcontrib>Dawson-Hughes, Bess</creatorcontrib><creatorcontrib>Ordovas, José M</creatorcontrib><creatorcontrib>O'Donnell, Christopher J</creatorcontrib><creatorcontrib>Gundberg, Caren M</creatorcontrib><creatorcontrib>Peterson, James W</creatorcontrib><creatorcontrib>Booth, Sarah L</creatorcontrib><title>Vitamin K, circulating cytokines, and bone mineral density in older men and women</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>BACKGROUND: Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro. OBJECTIVE: The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein (CRP) concentrations and 2) the effect of daily 500 μg phylloquinone supplementation for 3 y on cytokine concentrations. DESIGN: Concentrations of IL-6, osteoprotegerin, and CRP and bone mineral density (BMD) were measured at baseline and after 3 y of follow-up in 379 healthy men and women (60-81 y; 58.5% women) participating in a randomized trial that studied the effect of vitamin K supplementation on bone loss. RESULTS: Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6. Osteoprotegerin was associated positively with plasma phylloquinone and inversely with %ucOC. No differences were observed in the 3-y change in IL-6, osteoprotegerin, and CRP concentrations between participants who received phylloquinone supplementation and those who did not. Overall, no association was observed between the 3-y changes in circulating cytokines and BMD. CONCLUSIONS: Poor vitamin K status was associated with high concentrations of cytokines involved in bone turnover, but vitamin K supplementation did not confer a decrease in cytokine concentrations. The healthy status of this cohort may explain a lack of effect of vitamin K supplementation on cytokine concentrations. This trial was registered with www.clinicaltrials.gov as NCT00183001.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>bone density</subject><subject>Bone Density - drug effects</subject><subject>Bone Density - physiology</subject><subject>bone metabolism</subject><subject>Bones</subject><subject>C-Reactive Protein - metabolism</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - blood</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>elderly</subject><subject>elderly nutrition</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health Status</subject><subject>Humans</subject><subject>in vitro studies</subject><subject>interleukin-6</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>men</subject><subject>Middle Aged</subject><subject>Nutritional Status</subject><subject>osteoprotegerin</subject><subject>Osteoprotegerin - blood</subject><subject>Osteoprotegerin - metabolism</subject><subject>phylloquinone</subject><subject>Proteins</subject><subject>randomized clinical trials</subject><subject>Studies</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin K</subject><subject>Vitamin K - blood</subject><subject>Vitamin K - metabolism</subject><subject>Vitamin K 1 - administration & dosage</subject><subject>vitamin supplements</subject><subject>Vitamins</subject><subject>women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c9vFCEUwHFibOy2evSqxKSeOtsHzDBwNI0_mjYxxuqVsG-gYZ2BFmZi9r8vdTeaeILDh5eXL4S8ZrBmoMWF3WK8UGrN16KTz8iKaaEawaF_TlYAwBvNZHdMTkrZAjDeKvmCHDMllRY9W5FvP8NspxDp9TnFkHEZ7RziHcXdnH6F6Mo5tXGgmxQdrcxlO9LBxRLmHa2v0ji4TCcX_6jfqd5ekiNvx-JeHc5Tcvvp4-3ll-bm6-eryw83DbYtnxuJQoOTwvvOt21dDdtOMYkOvMaNdUprAYN1QvdCKeDOo7cKQaPaoARxSt7vx97n9LC4MpspFHTjaKNLSzFMd0yqnlX47j-4TUuOdTXDRa3Vd9BW1OwR5lRKdt7c5zDZvDMMzFNn89TZKGW4qZ2rf3MYumwmN_zTh7AVnB2ALWhHn23EUP46Dp0G1anq3u6dt8nYu1zNj-8cmADQnNfvEo_5kI5u</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Shea, M. Kyla</creator><creator>Dallal, Gerard E</creator><creator>Dawson-Hughes, Bess</creator><creator>Ordovas, José M</creator><creator>O'Donnell, Christopher J</creator><creator>Gundberg, Caren M</creator><creator>Peterson, James W</creator><creator>Booth, Sarah L</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20080801</creationdate><title>Vitamin K, circulating cytokines, and bone mineral density in older men and women</title><author>Shea, M. Kyla ; Dallal, Gerard E ; Dawson-Hughes, Bess ; Ordovas, José M ; O'Donnell, Christopher J ; Gundberg, Caren M ; Peterson, James W ; Booth, Sarah L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-6c390e63ff5f44001c45816ce0f9cbae89930dae39738802efcfa8c09c8bc603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>bone density</topic><topic>Bone Density - drug effects</topic><topic>Bone Density - physiology</topic><topic>bone metabolism</topic><topic>Bones</topic><topic>C-Reactive Protein - metabolism</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - blood</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>elderly</topic><topic>elderly nutrition</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health Status</topic><topic>Humans</topic><topic>in vitro studies</topic><topic>interleukin-6</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>men</topic><topic>Middle Aged</topic><topic>Nutritional Status</topic><topic>osteoprotegerin</topic><topic>Osteoprotegerin - blood</topic><topic>Osteoprotegerin - metabolism</topic><topic>phylloquinone</topic><topic>Proteins</topic><topic>randomized clinical trials</topic><topic>Studies</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin K</topic><topic>Vitamin K - blood</topic><topic>Vitamin K - metabolism</topic><topic>Vitamin K 1 - administration & dosage</topic><topic>vitamin supplements</topic><topic>Vitamins</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shea, M. 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Kyla</au><au>Dallal, Gerard E</au><au>Dawson-Hughes, Bess</au><au>Ordovas, José M</au><au>O'Donnell, Christopher J</au><au>Gundberg, Caren M</au><au>Peterson, James W</au><au>Booth, Sarah L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin K, circulating cytokines, and bone mineral density in older men and women</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>88</volume><issue>2</issue><spage>356</spage><epage>363</epage><pages>356-363</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>BACKGROUND: Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro. OBJECTIVE: The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein (CRP) concentrations and 2) the effect of daily 500 μg phylloquinone supplementation for 3 y on cytokine concentrations. DESIGN: Concentrations of IL-6, osteoprotegerin, and CRP and bone mineral density (BMD) were measured at baseline and after 3 y of follow-up in 379 healthy men and women (60-81 y; 58.5% women) participating in a randomized trial that studied the effect of vitamin K supplementation on bone loss. RESULTS: Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6. Osteoprotegerin was associated positively with plasma phylloquinone and inversely with %ucOC. No differences were observed in the 3-y change in IL-6, osteoprotegerin, and CRP concentrations between participants who received phylloquinone supplementation and those who did not. Overall, no association was observed between the 3-y changes in circulating cytokines and BMD. CONCLUSIONS: Poor vitamin K status was associated with high concentrations of cytokines involved in bone turnover, but vitamin K supplementation did not confer a decrease in cytokine concentrations. The healthy status of this cohort may explain a lack of effect of vitamin K supplementation on cytokine concentrations. This trial was registered with www.clinicaltrials.gov as NCT00183001.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>18689371</pmid><doi>10.1093/ajcn/88.2.356</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Area Under Curve Biological and medical sciences bone density Bone Density - drug effects Bone Density - physiology bone metabolism Bones C-Reactive Protein - metabolism Clinical trials Cytokines Cytokines - biosynthesis Cytokines - blood Dietary Supplements Double-Blind Method elderly elderly nutrition Feeding. Feeding behavior Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Health Status Humans in vitro studies interleukin-6 Interleukin-6 - biosynthesis Interleukin-6 - blood Male men Middle Aged Nutritional Status osteoprotegerin Osteoprotegerin - blood Osteoprotegerin - metabolism phylloquinone Proteins randomized clinical trials Studies Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin K Vitamin K - blood Vitamin K - metabolism Vitamin K 1 - administration & dosage vitamin supplements Vitamins women |
| title | Vitamin K, circulating cytokines, and bone mineral density in older men and women |
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