Activation of PKC epsilon induces lactotroph proliferation through ERK1/2 in response to phorbol ester

The aim of this investigation was to contribute to current knowledge about intracellular mechanisms that are involved in lactotroph cell proliferation, by evaluating the role of PKCα, PKCɛ and extracellular-signal regulated kinase (ERK) 1/2 in response to phorbol 12-myristate13-acetate (PMA). In pri...

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Veröffentlicht in:	Molecular and cellular endocrinology 2008-07, Vol.289 (1), p.77-84
Hauptverfasser:	Petiti, Juan Pablo, De Paul, Ana Lucía, Gutiérrez, Silvina, Palmeri, Claudia Mariela, Mukdsi, Jorge Humberto, Torres, Alicia Inés
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - drug effects Cells, Cultured Enzyme Activation - drug effects ERK1/2 Female Lactotroph Lactotrophs - cytology Lactotrophs - physiology MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinase 3 - metabolism PKCɛ PKCα PMA Proliferation Protein Kinase C-epsilon - metabolism Protein Transport - drug effects Rats Rats, Wistar Tetradecanoylphorbol Acetate - pharmacology
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