Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

Mec1-Ddc2 (ATR-ATRIP) is a key DNA-damage-sensing kinase that is recruited through the single-stranded (ss) DNA-binding replication protein A (RPA) to initiate the DNA damage checkpoint response. Activation of ATR-ATRIP in the absence of DNA damage is lethal. Therefore, it is important that damage-s...

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Veröffentlicht in:	Molecular cell 2017-10, Vol.68 (2), p.431-445.e5
Hauptverfasser:	Deshpande, Ishan, Seeber, Andrew, Shimada, Kenji, Keusch, Jeremy J., Gut, Heinz, Gasser, Susan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Substitution ATR ATRIP Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism checkpoint kinase crystal structure Crystallography, X-Ray dimerization DNA damage response DNA, Fungal - chemistry DNA, Fungal - genetics DNA, Fungal - metabolism DNA, Single-Stranded - chemistry DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Models, Molecular Mutation, Missense Protein Structure, Quaternary Protein Structure, Secondary Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism recruitment Replication Protein A - chemistry Replication Protein A - genetics Replication Protein A - metabolism Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism ssDNA
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