Single-center experience with intraoperative extracorporeal membrane oxygenation use in lung transplantation
Background: Studies have shown that survival after lung transplantation is impaired if extracorporeal membrane oxygenation (ECMO) support is implemented. We investigated the outcome and potential independent risk factors on survival in recipients undergoing lung transplantation with intraoperative E...
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| Veröffentlicht in: | International journal of artificial organs 2018-02, Vol.41 (2), p.89-93 |
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| container_title | International journal of artificial organs |
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| creator | Cosgun, Tugba Tomaszek, Sandra Opitz, Isabelle Wilhelm, Markus Schuurmans, Macé M. Weder, Walter Inci, Ilhan |
| description | Background:
Studies have shown that survival after lung transplantation is impaired if extracorporeal membrane oxygenation (ECMO) support is implemented. We investigated the outcome and potential independent risk factors on survival in recipients undergoing lung transplantation with intraoperative ECMO support.
Materials and methods:
Medical records of recipients were retrospectively evaluated (January 2000-December 2014). Retransplantation and bridge to transplantation on ECMO were excluded. Recipients (n = 291) were divided into 2 groups: those who needed intraoperative ECMO support (Group 1, n = 134) and those who did not receive intraoperative ECMO support (Group 2, n = 157). Independent risk factors were identified by a stepwise backward regression analysis.
Results:
1-year survival was 84.2% in Group 1 vs. 90.4% in Group 2, and 5-year survival was 52.8% in Group 1 vs. 70.5% in Group 2 (p = 0.002). Multivariate analysis indicated that recipient age (p = 0.001), renal replacement therapy (p = 0.001) and intraoperative ECMO support (p = 0.03) were significant risk factors for overall survival. The rate of postoperative early surgical complications was comparable between the two groups (p = 0.09). The number of patients requiring renal replacement therapy and experiencing late pulmonary complications was significantly higher in Group 1 (p = 0.02).
Conclusions:
Our data showed that lung transplantation with intraoperative ECMO support is associated with poor outcomes. |
| doi_str_mv | 10.5301/ijao.5000645 |
| format | Article |
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Studies have shown that survival after lung transplantation is impaired if extracorporeal membrane oxygenation (ECMO) support is implemented. We investigated the outcome and potential independent risk factors on survival in recipients undergoing lung transplantation with intraoperative ECMO support.
Materials and methods:
Medical records of recipients were retrospectively evaluated (January 2000-December 2014). Retransplantation and bridge to transplantation on ECMO were excluded. Recipients (n = 291) were divided into 2 groups: those who needed intraoperative ECMO support (Group 1, n = 134) and those who did not receive intraoperative ECMO support (Group 2, n = 157). Independent risk factors were identified by a stepwise backward regression analysis.
Results:
1-year survival was 84.2% in Group 1 vs. 90.4% in Group 2, and 5-year survival was 52.8% in Group 1 vs. 70.5% in Group 2 (p = 0.002). Multivariate analysis indicated that recipient age (p = 0.001), renal replacement therapy (p = 0.001) and intraoperative ECMO support (p = 0.03) were significant risk factors for overall survival. The rate of postoperative early surgical complications was comparable between the two groups (p = 0.09). The number of patients requiring renal replacement therapy and experiencing late pulmonary complications was significantly higher in Group 1 (p = 0.02).
Conclusions:
Our data showed that lung transplantation with intraoperative ECMO support is associated with poor outcomes.</description><identifier>ISSN: 0391-3988</identifier><identifier>EISSN: 1724-6040</identifier><identifier>DOI: 10.5301/ijao.5000645</identifier><identifier>PMID: 29027193</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Complications ; Lung transplantation ; Medical records ; Multivariate analysis ; Oxygenation ; Regression analysis ; Renal replacement therapy ; Respiratory therapy ; Risk analysis ; Risk factors ; Surgery ; Survival ; Therapy ; Transplantation</subject><ispartof>International journal of artificial organs, 2018-02, Vol.41 (2), p.89-93</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Wichtig Editore s.r.l. Feb 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-2afe8f5a53495422fdcdc0e4eff2aae2ba2972e78fbff58350d8a90e21bd5c1c3</citedby><cites>FETCH-LOGICAL-c423t-2afe8f5a53495422fdcdc0e4eff2aae2ba2972e78fbff58350d8a90e21bd5c1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/ijao.5000645$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/ijao.5000645$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,778,782,21806,27911,27912,43608,43609</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29027193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cosgun, Tugba</creatorcontrib><creatorcontrib>Tomaszek, Sandra</creatorcontrib><creatorcontrib>Opitz, Isabelle</creatorcontrib><creatorcontrib>Wilhelm, Markus</creatorcontrib><creatorcontrib>Schuurmans, Macé M.</creatorcontrib><creatorcontrib>Weder, Walter</creatorcontrib><creatorcontrib>Inci, Ilhan</creatorcontrib><title>Single-center experience with intraoperative extracorporeal membrane oxygenation use in lung transplantation</title><title>International journal of artificial organs</title><addtitle>Int J Artif Organs</addtitle><description>Background:
Studies have shown that survival after lung transplantation is impaired if extracorporeal membrane oxygenation (ECMO) support is implemented. We investigated the outcome and potential independent risk factors on survival in recipients undergoing lung transplantation with intraoperative ECMO support.
Materials and methods:
Medical records of recipients were retrospectively evaluated (January 2000-December 2014). Retransplantation and bridge to transplantation on ECMO were excluded. Recipients (n = 291) were divided into 2 groups: those who needed intraoperative ECMO support (Group 1, n = 134) and those who did not receive intraoperative ECMO support (Group 2, n = 157). Independent risk factors were identified by a stepwise backward regression analysis.
Results:
1-year survival was 84.2% in Group 1 vs. 90.4% in Group 2, and 5-year survival was 52.8% in Group 1 vs. 70.5% in Group 2 (p = 0.002). Multivariate analysis indicated that recipient age (p = 0.001), renal replacement therapy (p = 0.001) and intraoperative ECMO support (p = 0.03) were significant risk factors for overall survival. The rate of postoperative early surgical complications was comparable between the two groups (p = 0.09). The number of patients requiring renal replacement therapy and experiencing late pulmonary complications was significantly higher in Group 1 (p = 0.02).
Conclusions:
Our data showed that lung transplantation with intraoperative ECMO support is associated with poor outcomes.</description><subject>Complications</subject><subject>Lung transplantation</subject><subject>Medical records</subject><subject>Multivariate analysis</subject><subject>Oxygenation</subject><subject>Regression analysis</subject><subject>Renal replacement therapy</subject><subject>Respiratory therapy</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Survival</subject><subject>Therapy</subject><subject>Transplantation</subject><issn>0391-3988</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpt0U1P3DAQBmALFcF2y41zFakXKjXb8VcSHxHqBxISB-g5cpzxklVip3ZSln-P6S4gIU6WPY9fjzyEnFJYSQ70e7fRfiUBoBDygCxoyURegIAPZAFc0ZyrqjomH2PcANBCCHlEjpkCVlLFF6S_6dy6x9ygmzBkuB0xdOgMZvfddJd1bgrapzM9df8wldPW-DD6gLrPBhyaoB1mfvuwRpeMd9kcMV3L-tmts6RdHHvtpv-1T-TQ6j7iyX5dkj8_f9xe_M6vrn9dXpxf5UYwPuVMW6ys1JILJQVjtjWtARRoLdMaWaOZKhmWlW2slRWX0FZaATLatNJQw5fkbJc7Bv93xjjVQxcN9qkR9HOsqZJUlsCZSvTLG7rxc3Cpu5rRouQgREGT-rZTJvgYA9p6DN2gw0NNoX6aQv00hXo_hcQ_70PnZsD2BT9_ewJfdyDqNb6--G7YI3rpk3Q</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Cosgun, Tugba</creator><creator>Tomaszek, Sandra</creator><creator>Opitz, Isabelle</creator><creator>Wilhelm, Markus</creator><creator>Schuurmans, Macé M.</creator><creator>Weder, Walter</creator><creator>Inci, Ilhan</creator><general>SAGE Publications</general><general>Wichtig Editore s.r.l</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Single-center experience with intraoperative extracorporeal membrane oxygenation use in lung transplantation</title><author>Cosgun, Tugba ; Tomaszek, Sandra ; Opitz, Isabelle ; Wilhelm, Markus ; Schuurmans, Macé M. ; Weder, Walter ; Inci, Ilhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-2afe8f5a53495422fdcdc0e4eff2aae2ba2972e78fbff58350d8a90e21bd5c1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Complications</topic><topic>Lung transplantation</topic><topic>Medical records</topic><topic>Multivariate analysis</topic><topic>Oxygenation</topic><topic>Regression analysis</topic><topic>Renal replacement therapy</topic><topic>Respiratory therapy</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Survival</topic><topic>Therapy</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cosgun, Tugba</creatorcontrib><creatorcontrib>Tomaszek, Sandra</creatorcontrib><creatorcontrib>Opitz, Isabelle</creatorcontrib><creatorcontrib>Wilhelm, Markus</creatorcontrib><creatorcontrib>Schuurmans, Macé M.</creatorcontrib><creatorcontrib>Weder, Walter</creatorcontrib><creatorcontrib>Inci, Ilhan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cosgun, Tugba</au><au>Tomaszek, Sandra</au><au>Opitz, Isabelle</au><au>Wilhelm, Markus</au><au>Schuurmans, Macé M.</au><au>Weder, Walter</au><au>Inci, Ilhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-center experience with intraoperative extracorporeal membrane oxygenation use in lung transplantation</atitle><jtitle>International journal of artificial organs</jtitle><addtitle>Int J Artif Organs</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>41</volume><issue>2</issue><spage>89</spage><epage>93</epage><pages>89-93</pages><issn>0391-3988</issn><eissn>1724-6040</eissn><abstract>Background:
Studies have shown that survival after lung transplantation is impaired if extracorporeal membrane oxygenation (ECMO) support is implemented. We investigated the outcome and potential independent risk factors on survival in recipients undergoing lung transplantation with intraoperative ECMO support.
Materials and methods:
Medical records of recipients were retrospectively evaluated (January 2000-December 2014). Retransplantation and bridge to transplantation on ECMO were excluded. Recipients (n = 291) were divided into 2 groups: those who needed intraoperative ECMO support (Group 1, n = 134) and those who did not receive intraoperative ECMO support (Group 2, n = 157). Independent risk factors were identified by a stepwise backward regression analysis.
Results:
1-year survival was 84.2% in Group 1 vs. 90.4% in Group 2, and 5-year survival was 52.8% in Group 1 vs. 70.5% in Group 2 (p = 0.002). Multivariate analysis indicated that recipient age (p = 0.001), renal replacement therapy (p = 0.001) and intraoperative ECMO support (p = 0.03) were significant risk factors for overall survival. The rate of postoperative early surgical complications was comparable between the two groups (p = 0.09). The number of patients requiring renal replacement therapy and experiencing late pulmonary complications was significantly higher in Group 1 (p = 0.02).
Conclusions:
Our data showed that lung transplantation with intraoperative ECMO support is associated with poor outcomes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29027193</pmid><doi>10.5301/ijao.5000645</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of artificial organs, 2018-02, Vol.41 (2), p.89-93 |
| issn | 0391-3988 1724-6040 |
| language | eng |
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| source | SAGE Complete A-Z List |
| subjects | Complications Lung transplantation Medical records Multivariate analysis Oxygenation Regression analysis Renal replacement therapy Respiratory therapy Risk analysis Risk factors Surgery Survival Therapy Transplantation |
| title | Single-center experience with intraoperative extracorporeal membrane oxygenation use in lung transplantation |
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