Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia
Clinical outcomes and the genetic background of acute myeloid leukemia (AML) in adolescent and young adults (AYAs) are known to differ in younger children and older adults. To clarify the impact of genetic mutations on clinical outcomes of AYAs with AML, we analyzed data from the JPLSG AML-05 and JA...
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| Veröffentlicht in: | International journal of hematology 2018-02, Vol.107 (2), p.201-210 |
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| creator | Kuwatsuka, Yachiyo Tomizawa, Daisuke Kihara, Rika Nagata, Yasunobu Shiba, Norio Iijima-Yamashita, Yuka Shimada, Akira Deguchi, Takao Miyachi, Hayato Tawa, Akio Taga, Takashi Kinoshita, Akitoshi Nakayama, Hideki Kiyokawa, Nobutaka Saito, Akiko Moriya Koh, Katsuyoshi Goto, Hiroaki Kosaka, Yoshiyuki Asou, Norio Ohtake, Shigeki Miyawaki, Shuichi Miyazaki, Yasushi Sakura, Toru Ozawa, Yukiyasu Usui, Noriko Kanamori, Heiwa Ito, Yoshikazu Imai, Kiyotoshi Suehiro, Youko Kobayashi, Shinichi Kitamura, Kunio Sakaida, Emiko Ogawa, Seishi Naoe, Tomoki Hayashi, Yasuhide Horibe, Keizo Manabe, Atsushi Mizutani, Shuki Adachi, Souichi Kiyoi, Hitoshi |
| description | Clinical outcomes and the genetic background of acute myeloid leukemia (AML) in adolescent and young adults (AYAs) are known to differ in younger children and older adults. To clarify the impact of genetic mutations on clinical outcomes of AYAs with AML, we analyzed data from the JPLSG AML-05 and JALSG AML201 studies. AYAs aged 15–39 years (
n
= 103) were included.
FLT3
-ITD,
KIT
,
CEBPA
,
NRAS
,
KRAS
,
WT1
,
MLL
-PTD, and
NPM1
mutations were analyzed. Overall survival (OS) of the AYAs was 61% and event-free survival was 38% at 3 years.
FLT3
-ITD (HR 2.10; 95% CI 1.07–4.12;
p
= 0.031) and
NPM1
(HR 0.24; 95% CI 0.06–1.00;
p
= 0.050) mutations were associated with risk of overall mortality in multivariate analysis. OS was significantly different according to
FLT3
-ITD and
NPM1
mutation status (
p
= 0.03). Survival was 100% with
NPM1
mutations in the absence of
FLT3
-ITD and 35% (95% CI 14–57%) with
FLT3
-ITD in the absence of
NPM1
mutations. The OS of AYAs, children (
n
= 413) and older adults (
n
= 124) of the AML-05 and AML201 participants were significantly different (
p
|
| doi_str_mv | 10.1007/s12185-017-2340-z |
| format | Article |
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n
= 103) were included.
FLT3
-ITD,
KIT
,
CEBPA
,
NRAS
,
KRAS
,
WT1
,
MLL
-PTD, and
NPM1
mutations were analyzed. Overall survival (OS) of the AYAs was 61% and event-free survival was 38% at 3 years.
FLT3
-ITD (HR 2.10; 95% CI 1.07–4.12;
p
= 0.031) and
NPM1
(HR 0.24; 95% CI 0.06–1.00;
p
= 0.050) mutations were associated with risk of overall mortality in multivariate analysis. OS was significantly different according to
FLT3
-ITD and
NPM1
mutation status (
p
= 0.03). Survival was 100% with
NPM1
mutations in the absence of
FLT3
-ITD and 35% (95% CI 14–57%) with
FLT3
-ITD in the absence of
NPM1
mutations. The OS of AYAs, children (
n
= 413) and older adults (
n
= 124) of the AML-05 and AML201 participants were significantly different (
p
< 0.0001). This is the first report to combine clinical and genetic data of AYA AML from the major Japanese pediatric and adult study groups.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-017-2340-z</identifier><identifier>PMID: 29027108</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Acute myeloid leukemia ; Adolescent ; Adults ; Children ; Clinical outcomes ; Data processing ; fms-Like Tyrosine Kinase 3 - genetics ; Hematology ; Humans ; K-Ras protein ; Leukemia ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - mortality ; Medical prognosis ; Medicine ; Medicine & Public Health ; Multivariate Analysis ; Mutation ; Myeloid leukemia ; Nuclear Proteins - genetics ; Older people ; Oncology ; Original Article ; Prognosis ; Survival ; Survival Rate ; Teenagers ; Young Adult ; Young adults</subject><ispartof>International journal of hematology, 2018-02, Vol.107 (2), p.201-210</ispartof><rights>The Japanese Society of Hematology 2017</rights><rights>International Journal of Hematology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-f55175dee52240ac3b2cff00d55161f6be8f8d8a11e979aff348612a5b5e2fbb3</citedby><cites>FETCH-LOGICAL-c416t-f55175dee52240ac3b2cff00d55161f6be8f8d8a11e979aff348612a5b5e2fbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-017-2340-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-017-2340-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29027108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuwatsuka, Yachiyo</creatorcontrib><creatorcontrib>Tomizawa, Daisuke</creatorcontrib><creatorcontrib>Kihara, Rika</creatorcontrib><creatorcontrib>Nagata, Yasunobu</creatorcontrib><creatorcontrib>Shiba, Norio</creatorcontrib><creatorcontrib>Iijima-Yamashita, Yuka</creatorcontrib><creatorcontrib>Shimada, Akira</creatorcontrib><creatorcontrib>Deguchi, Takao</creatorcontrib><creatorcontrib>Miyachi, Hayato</creatorcontrib><creatorcontrib>Tawa, Akio</creatorcontrib><creatorcontrib>Taga, Takashi</creatorcontrib><creatorcontrib>Kinoshita, Akitoshi</creatorcontrib><creatorcontrib>Nakayama, Hideki</creatorcontrib><creatorcontrib>Kiyokawa, Nobutaka</creatorcontrib><creatorcontrib>Saito, Akiko Moriya</creatorcontrib><creatorcontrib>Koh, Katsuyoshi</creatorcontrib><creatorcontrib>Goto, Hiroaki</creatorcontrib><creatorcontrib>Kosaka, Yoshiyuki</creatorcontrib><creatorcontrib>Asou, Norio</creatorcontrib><creatorcontrib>Ohtake, Shigeki</creatorcontrib><creatorcontrib>Miyawaki, Shuichi</creatorcontrib><creatorcontrib>Miyazaki, Yasushi</creatorcontrib><creatorcontrib>Sakura, Toru</creatorcontrib><creatorcontrib>Ozawa, Yukiyasu</creatorcontrib><creatorcontrib>Usui, Noriko</creatorcontrib><creatorcontrib>Kanamori, Heiwa</creatorcontrib><creatorcontrib>Ito, Yoshikazu</creatorcontrib><creatorcontrib>Imai, Kiyotoshi</creatorcontrib><creatorcontrib>Suehiro, Youko</creatorcontrib><creatorcontrib>Kobayashi, Shinichi</creatorcontrib><creatorcontrib>Kitamura, Kunio</creatorcontrib><creatorcontrib>Sakaida, Emiko</creatorcontrib><creatorcontrib>Ogawa, Seishi</creatorcontrib><creatorcontrib>Naoe, Tomoki</creatorcontrib><creatorcontrib>Hayashi, Yasuhide</creatorcontrib><creatorcontrib>Horibe, Keizo</creatorcontrib><creatorcontrib>Manabe, Atsushi</creatorcontrib><creatorcontrib>Mizutani, Shuki</creatorcontrib><creatorcontrib>Adachi, Souichi</creatorcontrib><creatorcontrib>Kiyoi, Hitoshi</creatorcontrib><title>Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>Clinical outcomes and the genetic background of acute myeloid leukemia (AML) in adolescent and young adults (AYAs) are known to differ in younger children and older adults. To clarify the impact of genetic mutations on clinical outcomes of AYAs with AML, we analyzed data from the JPLSG AML-05 and JALSG AML201 studies. AYAs aged 15–39 years (
n
= 103) were included.
FLT3
-ITD,
KIT
,
CEBPA
,
NRAS
,
KRAS
,
WT1
,
MLL
-PTD, and
NPM1
mutations were analyzed. Overall survival (OS) of the AYAs was 61% and event-free survival was 38% at 3 years.
FLT3
-ITD (HR 2.10; 95% CI 1.07–4.12;
p
= 0.031) and
NPM1
(HR 0.24; 95% CI 0.06–1.00;
p
= 0.050) mutations were associated with risk of overall mortality in multivariate analysis. OS was significantly different according to
FLT3
-ITD and
NPM1
mutation status (
p
= 0.03). Survival was 100% with
NPM1
mutations in the absence of
FLT3
-ITD and 35% (95% CI 14–57%) with
FLT3
-ITD in the absence of
NPM1
mutations. The OS of AYAs, children (
n
= 413) and older adults (
n
= 124) of the AML-05 and AML201 participants were significantly different (
p
< 0.0001). This is the first report to combine clinical and genetic data of AYA AML from the major Japanese pediatric and adult study groups.</description><subject>Acute myeloid leukemia</subject><subject>Adolescent</subject><subject>Adults</subject><subject>Children</subject><subject>Clinical outcomes</subject><subject>Data processing</subject><subject>fms-Like Tyrosine Kinase 3 - genetics</subject><subject>Hematology</subject><subject>Humans</subject><subject>K-Ras protein</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - mortality</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate Analysis</subject><subject>Mutation</subject><subject>Myeloid leukemia</subject><subject>Nuclear Proteins - genetics</subject><subject>Older people</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Teenagers</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1v1DAQhi1URLeFH9ALstQLlxSPE8fJsaoKVFoJDnA2TjIOKYld_EG1--vxKluEKnGy9PqZd0YPIRfAroAx-T4Ah0YUDGTBy4oV-xdkA00tilLK6oRsWMtFISSwU3IWwj3LIKvkK3LKW8Zz3GzI9y_ejdaFOPX0t54TUmfoiBYPwZKijpOzgU6W6sHNGHq0kWo70J1LdsxhmmOgj1P8QXWfItJlh7ObBjpj-onLpF-Tl0bPAd8c33Py7cPt15tPxfbzx7ub623RV1DHwggBUgyIgvOK6b7seG8MY0POazB1h41phkYDYCtbbUxZNTVwLTqB3HRdeU7erb0P3v1KGKJapnztPGuLLgUFrQBRt7xkGb18ht675G2-LlNtWbOqBZkpWKneuxA8GvXgp0X7nQKmDvrVql9lq-qgX-3zzNtjc-oWHP5OPPnOAF-BkL_siP6f1f9t_QP5ZZFt</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Kuwatsuka, Yachiyo</creator><creator>Tomizawa, Daisuke</creator><creator>Kihara, Rika</creator><creator>Nagata, Yasunobu</creator><creator>Shiba, Norio</creator><creator>Iijima-Yamashita, Yuka</creator><creator>Shimada, Akira</creator><creator>Deguchi, Takao</creator><creator>Miyachi, Hayato</creator><creator>Tawa, Akio</creator><creator>Taga, Takashi</creator><creator>Kinoshita, Akitoshi</creator><creator>Nakayama, Hideki</creator><creator>Kiyokawa, Nobutaka</creator><creator>Saito, Akiko Moriya</creator><creator>Koh, Katsuyoshi</creator><creator>Goto, Hiroaki</creator><creator>Kosaka, Yoshiyuki</creator><creator>Asou, Norio</creator><creator>Ohtake, Shigeki</creator><creator>Miyawaki, Shuichi</creator><creator>Miyazaki, Yasushi</creator><creator>Sakura, Toru</creator><creator>Ozawa, Yukiyasu</creator><creator>Usui, Noriko</creator><creator>Kanamori, Heiwa</creator><creator>Ito, Yoshikazu</creator><creator>Imai, Kiyotoshi</creator><creator>Suehiro, Youko</creator><creator>Kobayashi, Shinichi</creator><creator>Kitamura, Kunio</creator><creator>Sakaida, Emiko</creator><creator>Ogawa, Seishi</creator><creator>Naoe, Tomoki</creator><creator>Hayashi, Yasuhide</creator><creator>Horibe, Keizo</creator><creator>Manabe, Atsushi</creator><creator>Mizutani, Shuki</creator><creator>Adachi, Souichi</creator><creator>Kiyoi, Hitoshi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia</title><author>Kuwatsuka, Yachiyo ; Tomizawa, Daisuke ; Kihara, Rika ; Nagata, Yasunobu ; Shiba, Norio ; Iijima-Yamashita, Yuka ; Shimada, Akira ; Deguchi, Takao ; Miyachi, Hayato ; Tawa, Akio ; Taga, Takashi ; Kinoshita, Akitoshi ; Nakayama, Hideki ; Kiyokawa, Nobutaka ; Saito, Akiko Moriya ; Koh, Katsuyoshi ; Goto, Hiroaki ; Kosaka, Yoshiyuki ; Asou, Norio ; Ohtake, Shigeki ; Miyawaki, Shuichi ; Miyazaki, Yasushi ; Sakura, Toru ; Ozawa, Yukiyasu ; Usui, Noriko ; Kanamori, Heiwa ; Ito, Yoshikazu ; Imai, Kiyotoshi ; Suehiro, Youko ; Kobayashi, Shinichi ; Kitamura, Kunio ; Sakaida, Emiko ; Ogawa, Seishi ; Naoe, Tomoki ; Hayashi, Yasuhide ; Horibe, Keizo ; Manabe, Atsushi ; Mizutani, Shuki ; Adachi, Souichi ; Kiyoi, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-f55175dee52240ac3b2cff00d55161f6be8f8d8a11e979aff348612a5b5e2fbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acute myeloid leukemia</topic><topic>Adolescent</topic><topic>Adults</topic><topic>Children</topic><topic>Clinical outcomes</topic><topic>Data processing</topic><topic>fms-Like Tyrosine Kinase 3 - genetics</topic><topic>Hematology</topic><topic>Humans</topic><topic>K-Ras protein</topic><topic>Leukemia</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - mortality</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate Analysis</topic><topic>Mutation</topic><topic>Myeloid leukemia</topic><topic>Nuclear Proteins - genetics</topic><topic>Older people</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Teenagers</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuwatsuka, 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(purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuwatsuka, Yachiyo</au><au>Tomizawa, Daisuke</au><au>Kihara, Rika</au><au>Nagata, Yasunobu</au><au>Shiba, Norio</au><au>Iijima-Yamashita, Yuka</au><au>Shimada, Akira</au><au>Deguchi, Takao</au><au>Miyachi, Hayato</au><au>Tawa, Akio</au><au>Taga, Takashi</au><au>Kinoshita, Akitoshi</au><au>Nakayama, Hideki</au><au>Kiyokawa, Nobutaka</au><au>Saito, Akiko Moriya</au><au>Koh, Katsuyoshi</au><au>Goto, Hiroaki</au><au>Kosaka, Yoshiyuki</au><au>Asou, Norio</au><au>Ohtake, Shigeki</au><au>Miyawaki, Shuichi</au><au>Miyazaki, Yasushi</au><au>Sakura, Toru</au><au>Ozawa, Yukiyasu</au><au>Usui, Noriko</au><au>Kanamori, Heiwa</au><au>Ito, Yoshikazu</au><au>Imai, Kiyotoshi</au><au>Suehiro, Youko</au><au>Kobayashi, Shinichi</au><au>Kitamura, Kunio</au><au>Sakaida, Emiko</au><au>Ogawa, Seishi</au><au>Naoe, Tomoki</au><au>Hayashi, Yasuhide</au><au>Horibe, Keizo</au><au>Manabe, Atsushi</au><au>Mizutani, Shuki</au><au>Adachi, Souichi</au><au>Kiyoi, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>107</volume><issue>2</issue><spage>201</spage><epage>210</epage><pages>201-210</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>Clinical outcomes and the genetic background of acute myeloid leukemia (AML) in adolescent and young adults (AYAs) are known to differ in younger children and older adults. To clarify the impact of genetic mutations on clinical outcomes of AYAs with AML, we analyzed data from the JPLSG AML-05 and JALSG AML201 studies. AYAs aged 15–39 years (
n
= 103) were included.
FLT3
-ITD,
KIT
,
CEBPA
,
NRAS
,
KRAS
,
WT1
,
MLL
-PTD, and
NPM1
mutations were analyzed. Overall survival (OS) of the AYAs was 61% and event-free survival was 38% at 3 years.
FLT3
-ITD (HR 2.10; 95% CI 1.07–4.12;
p
= 0.031) and
NPM1
(HR 0.24; 95% CI 0.06–1.00;
p
= 0.050) mutations were associated with risk of overall mortality in multivariate analysis. OS was significantly different according to
FLT3
-ITD and
NPM1
mutation status (
p
= 0.03). Survival was 100% with
NPM1
mutations in the absence of
FLT3
-ITD and 35% (95% CI 14–57%) with
FLT3
-ITD in the absence of
NPM1
mutations. The OS of AYAs, children (
n
= 413) and older adults (
n
= 124) of the AML-05 and AML201 participants were significantly different (
p
< 0.0001). This is the first report to combine clinical and genetic data of AYA AML from the major Japanese pediatric and adult study groups.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>29027108</pmid><doi>10.1007/s12185-017-2340-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-5710 |
| ispartof | International journal of hematology, 2018-02, Vol.107 (2), p.201-210 |
| issn | 0925-5710 1865-3774 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1951569230 |
| source | MEDLINE; Springer Journals |
| subjects | Acute myeloid leukemia Adolescent Adults Children Clinical outcomes Data processing fms-Like Tyrosine Kinase 3 - genetics Hematology Humans K-Ras protein Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Medical prognosis Medicine Medicine & Public Health Multivariate Analysis Mutation Myeloid leukemia Nuclear Proteins - genetics Older people Oncology Original Article Prognosis Survival Survival Rate Teenagers Young Adult Young adults |
| title | Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T22%3A31%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20value%20of%20genetic%20mutations%20in%20adolescent%20and%20young%20adults%20with%20acute%20myeloid%20leukemia&rft.jtitle=International%20journal%20of%20hematology&rft.au=Kuwatsuka,%20Yachiyo&rft.date=2018-02-01&rft.volume=107&rft.issue=2&rft.spage=201&rft.epage=210&rft.pages=201-210&rft.issn=0925-5710&rft.eissn=1865-3774&rft_id=info:doi/10.1007/s12185-017-2340-z&rft_dat=%3Cproquest_cross%3E1993604917%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1993604917&rft_id=info:pmid/29027108&rfr_iscdi=true |