Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats
Objectives The objective of this study was to investigate the effects of mate tea (MT) [ Ilex paraguariensis ] on alveolar socket healing after tooth extraction. Materials and methods Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 2...
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| Veröffentlicht in: | Clinical oral investigations 2018-04, Vol.22 (3), p.1449-1461 |
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| creator | Brasilino, Matheus da Silva Stringhetta-Garcia, Camila Tami Pereira, Camila Scacco Pereira, Ariana Aparecida Ferreira Stringhetta, Karina Leopoldino, Andréia Machado Crivelini, Marcelo Macedo Ervolino, Edilson Dornelles, Rita Cássia Menegati de Melo Stevanato Nakamune, Ana Cláudia Chaves-Neto, Antonio Hernandes |
| description | Objectives
The objective of this study was to investigate the effects of mate tea (MT) [
Ilex paraguariensis
] on alveolar socket healing after tooth extraction.
Materials and methods
Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum.
Results
Histometry evidenced an increase in bone area (
P
|
| doi_str_mv | 10.1007/s00784-017-2249-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1951568918</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1951568918</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-14df34d6400b31cc285660ff057d659011aada4fae028cdf2385da512f22f9a63</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi1URD_gB3CpLPVSDgGPv5IcUQV0pSIucLZmk_FuShIvtlO1_x4v21IJiYvHkp_3nfG8jL0F8R6EqD-kcjS6ElBXUuq2ghfsBLSylaprOPpzl5VtGzhmpyndCgHa1uoVO5atUFILdcLyV8zEMyG_XI10z3cYcbNgHGhOQ3rHh2kXwx0lvg4zcR_ihHkIMx9mnrfEcbyjMGLkKXQ_KfMt4TjMG44-U-Q5hLzldJ8jdk-qiDm9Zi89jonePNYz9uPzp-9X19XNty-rq483VafB5Ap075XurRZiraDrZGOsFd4LU_fWtAIAsUftkYRsut5L1ZgeDUgvpW_RqjN2efAtf_i1UMpuGlJH44gzhSU5aA0Y27TQFPTiH_Q2LHEu0zlZ9msaoURdKDhQXQwpRfJuF4cJ44MD4faRuEMkrkjcPhIHRXP-6LysJ-r_Kp4yKIA8AKk8zRuKz63_7_obanGW3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2017580307</pqid></control><display><type>article</type><title>Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Brasilino, Matheus da Silva ; Stringhetta-Garcia, Camila Tami ; Pereira, Camila Scacco ; Pereira, Ariana Aparecida Ferreira ; Stringhetta, Karina ; Leopoldino, Andréia Machado ; Crivelini, Marcelo Macedo ; Ervolino, Edilson ; Dornelles, Rita Cássia Menegati ; de Melo Stevanato Nakamune, Ana Cláudia ; Chaves-Neto, Antonio Hernandes</creator><creatorcontrib>Brasilino, Matheus da Silva ; Stringhetta-Garcia, Camila Tami ; Pereira, Camila Scacco ; Pereira, Ariana Aparecida Ferreira ; Stringhetta, Karina ; Leopoldino, Andréia Machado ; Crivelini, Marcelo Macedo ; Ervolino, Edilson ; Dornelles, Rita Cássia Menegati ; de Melo Stevanato Nakamune, Ana Cláudia ; Chaves-Neto, Antonio Hernandes</creatorcontrib><description><![CDATA[Objectives
The objective of this study was to investigate the effects of mate tea (MT) [
Ilex paraguariensis
] on alveolar socket healing after tooth extraction.
Materials and methods
Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum.
Results
Histometry evidenced an increase in bone area (
P
< 0.0001) and osteocyte density (
P
< 0.0001). MT increased immunolabeling of MnSOD (
P
< 0.001), OCN (
P
< 0.0001), RANKL (
P
< 0.001), OPG (
P
< 0.0001), and TRAP
(P
< 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (
P
< 0.05) and TRAP (
P
< 0.0001) activities. MT increased the TAC (
P
< 0.001), whereas it reduced MDA concentrations (
P
< 0.0001).
Conclusions
MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction.
Clinical relevance
Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction.]]></description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-017-2249-1</identifier><identifier>PMID: 29032403</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acid phosphatase (tartrate-resistant) ; Alkaline phosphatase ; Alkaline Phosphatase - blood ; Alveolar bone ; Animals ; Antioxidants ; Antioxidants - metabolism ; Beverages ; Bone density ; Bone growth ; Bone healing ; Calcium ; Calcium - blood ; Dentistry ; Ilex paraguariensis ; Immunohistochemistry ; Male ; Malondialdehyde ; Malondialdehyde - blood ; Manganese ; Medicine ; Original Article ; Osteocalcin ; Osteocalcin - metabolism ; Osteogenesis ; Osteogenesis - drug effects ; Osteoprotegerin ; Osteoprotegerin - metabolism ; Phosphatase ; Phosphorus ; Phosphorus - blood ; RANK Ligand - metabolism ; Rats ; Rats, Wistar ; Rodents ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Tartrate-Resistant Acid Phosphatase - metabolism ; Tea ; Teeth ; Tooth Extraction ; Tooth extractions ; Tooth Socket - drug effects ; TRANCE protein</subject><ispartof>Clinical oral investigations, 2018-04, Vol.22 (3), p.1449-1461</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>Clinical Oral Investigations is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-14df34d6400b31cc285660ff057d659011aada4fae028cdf2385da512f22f9a63</citedby><cites>FETCH-LOGICAL-c415t-14df34d6400b31cc285660ff057d659011aada4fae028cdf2385da512f22f9a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-017-2249-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-017-2249-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29032403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brasilino, Matheus da Silva</creatorcontrib><creatorcontrib>Stringhetta-Garcia, Camila Tami</creatorcontrib><creatorcontrib>Pereira, Camila Scacco</creatorcontrib><creatorcontrib>Pereira, Ariana Aparecida Ferreira</creatorcontrib><creatorcontrib>Stringhetta, Karina</creatorcontrib><creatorcontrib>Leopoldino, Andréia Machado</creatorcontrib><creatorcontrib>Crivelini, Marcelo Macedo</creatorcontrib><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Dornelles, Rita Cássia Menegati</creatorcontrib><creatorcontrib>de Melo Stevanato Nakamune, Ana Cláudia</creatorcontrib><creatorcontrib>Chaves-Neto, Antonio Hernandes</creatorcontrib><title>Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description><![CDATA[Objectives
The objective of this study was to investigate the effects of mate tea (MT) [
Ilex paraguariensis
] on alveolar socket healing after tooth extraction.
Materials and methods
Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum.
Results
Histometry evidenced an increase in bone area (
P
< 0.0001) and osteocyte density (
P
< 0.0001). MT increased immunolabeling of MnSOD (
P
< 0.001), OCN (
P
< 0.0001), RANKL (
P
< 0.001), OPG (
P
< 0.0001), and TRAP
(P
< 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (
P
< 0.05) and TRAP (
P
< 0.0001) activities. MT increased the TAC (
P
< 0.001), whereas it reduced MDA concentrations (
P
< 0.0001).
Conclusions
MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction.
Clinical relevance
Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction.]]></description><subject>Acid phosphatase (tartrate-resistant)</subject><subject>Alkaline phosphatase</subject><subject>Alkaline Phosphatase - blood</subject><subject>Alveolar bone</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Beverages</subject><subject>Bone density</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Dentistry</subject><subject>Ilex paraguariensis</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Manganese</subject><subject>Medicine</subject><subject>Original Article</subject><subject>Osteocalcin</subject><subject>Osteocalcin - metabolism</subject><subject>Osteogenesis</subject><subject>Osteogenesis - drug effects</subject><subject>Osteoprotegerin</subject><subject>Osteoprotegerin - metabolism</subject><subject>Phosphatase</subject><subject>Phosphorus</subject><subject>Phosphorus - blood</subject><subject>RANK Ligand - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tartrate-Resistant Acid Phosphatase - metabolism</subject><subject>Tea</subject><subject>Teeth</subject><subject>Tooth Extraction</subject><subject>Tooth extractions</subject><subject>Tooth Socket - drug effects</subject><subject>TRANCE protein</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhi1URD_gB3CpLPVSDgGPv5IcUQV0pSIucLZmk_FuShIvtlO1_x4v21IJiYvHkp_3nfG8jL0F8R6EqD-kcjS6ElBXUuq2ghfsBLSylaprOPpzl5VtGzhmpyndCgHa1uoVO5atUFILdcLyV8zEMyG_XI10z3cYcbNgHGhOQ3rHh2kXwx0lvg4zcR_ihHkIMx9mnrfEcbyjMGLkKXQ_KfMt4TjMG44-U-Q5hLzldJ8jdk-qiDm9Zi89jonePNYz9uPzp-9X19XNty-rq483VafB5Ap075XurRZiraDrZGOsFd4LU_fWtAIAsUftkYRsut5L1ZgeDUgvpW_RqjN2efAtf_i1UMpuGlJH44gzhSU5aA0Y27TQFPTiH_Q2LHEu0zlZ9msaoURdKDhQXQwpRfJuF4cJ44MD4faRuEMkrkjcPhIHRXP-6LysJ-r_Kp4yKIA8AKk8zRuKz63_7_obanGW3w</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Brasilino, Matheus da Silva</creator><creator>Stringhetta-Garcia, Camila Tami</creator><creator>Pereira, Camila Scacco</creator><creator>Pereira, Ariana Aparecida Ferreira</creator><creator>Stringhetta, Karina</creator><creator>Leopoldino, Andréia Machado</creator><creator>Crivelini, Marcelo Macedo</creator><creator>Ervolino, Edilson</creator><creator>Dornelles, Rita Cássia Menegati</creator><creator>de Melo Stevanato Nakamune, Ana Cláudia</creator><creator>Chaves-Neto, Antonio Hernandes</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats</title><author>Brasilino, Matheus da Silva ; Stringhetta-Garcia, Camila Tami ; Pereira, Camila Scacco ; Pereira, Ariana Aparecida Ferreira ; Stringhetta, Karina ; Leopoldino, Andréia Machado ; Crivelini, Marcelo Macedo ; Ervolino, Edilson ; Dornelles, Rita Cássia Menegati ; de Melo Stevanato Nakamune, Ana Cláudia ; Chaves-Neto, Antonio Hernandes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-14df34d6400b31cc285660ff057d659011aada4fae028cdf2385da512f22f9a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acid phosphatase (tartrate-resistant)</topic><topic>Alkaline phosphatase</topic><topic>Alkaline Phosphatase - blood</topic><topic>Alveolar bone</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Beverages</topic><topic>Bone density</topic><topic>Bone growth</topic><topic>Bone healing</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Dentistry</topic><topic>Ilex paraguariensis</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Manganese</topic><topic>Medicine</topic><topic>Original Article</topic><topic>Osteocalcin</topic><topic>Osteocalcin - metabolism</topic><topic>Osteogenesis</topic><topic>Osteogenesis - drug effects</topic><topic>Osteoprotegerin</topic><topic>Osteoprotegerin - metabolism</topic><topic>Phosphatase</topic><topic>Phosphorus</topic><topic>Phosphorus - blood</topic><topic>RANK Ligand - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tartrate-Resistant Acid Phosphatase - metabolism</topic><topic>Tea</topic><topic>Teeth</topic><topic>Tooth Extraction</topic><topic>Tooth extractions</topic><topic>Tooth Socket - drug effects</topic><topic>TRANCE protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brasilino, Matheus da Silva</creatorcontrib><creatorcontrib>Stringhetta-Garcia, Camila Tami</creatorcontrib><creatorcontrib>Pereira, Camila Scacco</creatorcontrib><creatorcontrib>Pereira, Ariana Aparecida Ferreira</creatorcontrib><creatorcontrib>Stringhetta, Karina</creatorcontrib><creatorcontrib>Leopoldino, Andréia Machado</creatorcontrib><creatorcontrib>Crivelini, Marcelo Macedo</creatorcontrib><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Dornelles, Rita Cássia Menegati</creatorcontrib><creatorcontrib>de Melo Stevanato Nakamune, Ana Cláudia</creatorcontrib><creatorcontrib>Chaves-Neto, Antonio Hernandes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brasilino, Matheus da Silva</au><au>Stringhetta-Garcia, Camila Tami</au><au>Pereira, Camila Scacco</au><au>Pereira, Ariana Aparecida Ferreira</au><au>Stringhetta, Karina</au><au>Leopoldino, Andréia Machado</au><au>Crivelini, Marcelo Macedo</au><au>Ervolino, Edilson</au><au>Dornelles, Rita Cássia Menegati</au><au>de Melo Stevanato Nakamune, Ana Cláudia</au><au>Chaves-Neto, Antonio Hernandes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>22</volume><issue>3</issue><spage>1449</spage><epage>1461</epage><pages>1449-1461</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract><![CDATA[Objectives
The objective of this study was to investigate the effects of mate tea (MT) [
Ilex paraguariensis
] on alveolar socket healing after tooth extraction.
Materials and methods
Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum.
Results
Histometry evidenced an increase in bone area (
P
< 0.0001) and osteocyte density (
P
< 0.0001). MT increased immunolabeling of MnSOD (
P
< 0.001), OCN (
P
< 0.0001), RANKL (
P
< 0.001), OPG (
P
< 0.0001), and TRAP
(P
< 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (
P
< 0.05) and TRAP (
P
< 0.0001) activities. MT increased the TAC (
P
< 0.001), whereas it reduced MDA concentrations (
P
< 0.0001).
Conclusions
MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction.
Clinical relevance
Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29032403</pmid><doi>10.1007/s00784-017-2249-1</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2018-04, Vol.22 (3), p.1449-1461 |
| issn | 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1951568918 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acid phosphatase (tartrate-resistant) Alkaline phosphatase Alkaline Phosphatase - blood Alveolar bone Animals Antioxidants Antioxidants - metabolism Beverages Bone density Bone growth Bone healing Calcium Calcium - blood Dentistry Ilex paraguariensis Immunohistochemistry Male Malondialdehyde Malondialdehyde - blood Manganese Medicine Original Article Osteocalcin Osteocalcin - metabolism Osteogenesis Osteogenesis - drug effects Osteoprotegerin Osteoprotegerin - metabolism Phosphatase Phosphorus Phosphorus - blood RANK Ligand - metabolism Rats Rats, Wistar Rodents Superoxide dismutase Superoxide Dismutase - metabolism Tartrate-Resistant Acid Phosphatase - metabolism Tea Teeth Tooth Extraction Tooth extractions Tooth Socket - drug effects TRANCE protein |
| title | Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats |
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