Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells
Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic compounds including retrochalcones. Potential pharmacological properties of Lico B include anti‐inflammatory, anti‐bacterial, anti‐oxidant, and anti‐cancer...
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| Veröffentlicht in: | Phytotherapy research 2017-12, Vol.31 (12), p.1858-1867 |
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| creator | Kang, Tae‐Ho Yoon, Goo Kang, In‐A Oh, Ha‐Na Chae, Jung‐Il Shim, Jung‐Hyun |
| description | Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic compounds including retrochalcones. Potential pharmacological properties of Lico B include anti‐inflammatory, anti‐bacterial, anti‐oxidant, and anti‐cancer activities. However, its biological effects on melanoma and squamous cell carcinoma (SCC) are unknown. Based on these known facts, this study investigated the role of Lico B in apoptosis, through the extrinsic and intrinsic pathways and additional regulation of specificity protein 1 in human skin cancer cell lines. Annexin V/7‐aminoactinomycin D staining, western blot analysis, mitochondrial membrane potential assay, and an anchorage‐independent cell transformation assay demonstrated that Lico B treatment of human melanoma and SCC cells significantly inhibited cell proliferation and induced apoptotic cell death. More specifically, Lico B induced apoptosis through the regulation of specificity protein 1 and apoptosis‐related proteins including CCAAT/enhancer‐binding protein homologous protein, death receptors, and poly (ADP‐ribose) polymerase. These results indicate that Lico B has apoptotic effect on A375 and A431 skin cancer cells, suggesting the potential value of Lico B for the treatment of human melanoma and SCC. Copyright © 2017 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.5928 |
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Potential pharmacological properties of Lico B include anti‐inflammatory, anti‐bacterial, anti‐oxidant, and anti‐cancer activities. However, its biological effects on melanoma and squamous cell carcinoma (SCC) are unknown. Based on these known facts, this study investigated the role of Lico B in apoptosis, through the extrinsic and intrinsic pathways and additional regulation of specificity protein 1 in human skin cancer cell lines. Annexin V/7‐aminoactinomycin D staining, western blot analysis, mitochondrial membrane potential assay, and an anchorage‐independent cell transformation assay demonstrated that Lico B treatment of human melanoma and SCC cells significantly inhibited cell proliferation and induced apoptotic cell death. More specifically, Lico B induced apoptosis through the regulation of specificity protein 1 and apoptosis‐related proteins including CCAAT/enhancer‐binding protein homologous protein, death receptors, and poly (ADP‐ribose) polymerase. These results indicate that Lico B has apoptotic effect on A375 and A431 skin cancer cells, suggesting the potential value of Lico B for the treatment of human melanoma and SCC. Copyright © 2017 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5928</identifier><identifier>PMID: 29027311</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adenosine diphosphate ; Annexin V ; Anticancer properties ; Apoptosis ; Apoptosis - drug effects ; Bacteria ; Biological effects ; Biological Products - chemistry ; Cancer ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - pathology ; CCAAT/enhancer-binding protein ; Cell death ; Cell proliferation ; Chalcones - chemistry ; death receptor ; Death receptors ; Glycyrrhiza ; Homology ; human skin cancer ; Humans ; Inflammation ; licochalcone B ; Lymphocytes B ; Melanoma ; Melanoma - drug therapy ; Melanoma - pathology ; Melanoma, Cutaneous Malignant ; Membrane potential ; Mitochondria ; mitochondrial membrane potential ; Organic compounds ; Pharmacology ; Proteins ; Receptors ; Ribose ; Skin cancer ; Skin Neoplasms - drug therapy ; Skin Neoplasms - pathology ; specificity protein 1 ; Squamous cell carcinoma ; Tumor cell lines</subject><ispartof>Phytotherapy research, 2017-12, Vol.31 (12), p.1858-1867</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3498-871fd48bb8c220a95ca650848f6644296adfd95aa2635f41325d78da43cc29e93</citedby><cites>FETCH-LOGICAL-c3498-871fd48bb8c220a95ca650848f6644296adfd95aa2635f41325d78da43cc29e93</cites><orcidid>0000-0002-4062-4016</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5928$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5928$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29027311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Tae‐Ho</creatorcontrib><creatorcontrib>Yoon, Goo</creatorcontrib><creatorcontrib>Kang, In‐A</creatorcontrib><creatorcontrib>Oh, Ha‐Na</creatorcontrib><creatorcontrib>Chae, Jung‐Il</creatorcontrib><creatorcontrib>Shim, Jung‐Hyun</creatorcontrib><title>Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic compounds including retrochalcones. Potential pharmacological properties of Lico B include anti‐inflammatory, anti‐bacterial, anti‐oxidant, and anti‐cancer activities. However, its biological effects on melanoma and squamous cell carcinoma (SCC) are unknown. Based on these known facts, this study investigated the role of Lico B in apoptosis, through the extrinsic and intrinsic pathways and additional regulation of specificity protein 1 in human skin cancer cell lines. Annexin V/7‐aminoactinomycin D staining, western blot analysis, mitochondrial membrane potential assay, and an anchorage‐independent cell transformation assay demonstrated that Lico B treatment of human melanoma and SCC cells significantly inhibited cell proliferation and induced apoptotic cell death. More specifically, Lico B induced apoptosis through the regulation of specificity protein 1 and apoptosis‐related proteins including CCAAT/enhancer‐binding protein homologous protein, death receptors, and poly (ADP‐ribose) polymerase. These results indicate that Lico B has apoptotic effect on A375 and A431 skin cancer cells, suggesting the potential value of Lico B for the treatment of human melanoma and SCC. Copyright © 2017 John Wiley & Sons, Ltd.</description><subject>Adenosine diphosphate</subject><subject>Annexin V</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bacteria</subject><subject>Biological effects</subject><subject>Biological Products - chemistry</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>CCAAT/enhancer-binding protein</subject><subject>Cell death</subject><subject>Cell proliferation</subject><subject>Chalcones - chemistry</subject><subject>death receptor</subject><subject>Death receptors</subject><subject>Glycyrrhiza</subject><subject>Homology</subject><subject>human skin cancer</subject><subject>Humans</subject><subject>Inflammation</subject><subject>licochalcone B</subject><subject>Lymphocytes B</subject><subject>Melanoma</subject><subject>Melanoma - drug therapy</subject><subject>Melanoma - pathology</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>Membrane potential</subject><subject>Mitochondria</subject><subject>mitochondrial membrane potential</subject><subject>Organic compounds</subject><subject>Pharmacology</subject><subject>Proteins</subject><subject>Receptors</subject><subject>Ribose</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - pathology</subject><subject>specificity protein 1</subject><subject>Squamous cell carcinoma</subject><subject>Tumor cell lines</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtrFDEYhoModq2Cv0AC3rQXU3OcSS63S20X1gO2gnfDt5kMps4k02SC9l_0J5tutyKCVznw5Ple8iL0mpITSgh7N83xRGqmnqAFJVpXVDb8KVoQLWklqPp2gF6kdE0I0YyI5-iAacIaTukC3X2EOUcY8CqMU8i-wxtngvkOgwne4lO89l02tsNnv-bofHIGQ4HW_vG0nMI0h-QSdh5f5BE8vvxRth_sAD6MgI-WvJHHu1eXNxnGkBNe2aFMhGjcHhGcHu9u00v0rIch2Vf79RB9fX92tbqoNp_O16vlpjJcaFWphvadUNutMowR0NJALYkSqq9rIZiuoes7LQFYzWUvKGeya1QHghvDtNX8EB09eKcYbrJNczu6ZEoC8LZEbGn5O1k3DZEFffsPeh1y9CVdoRrGBGXqL6GJIaVo-3aKboR421LS3rfUlpba-5YK-mYvzNvRdn_Ax1oKUD0AP91gb_8raj9ffdkJfwObA5ls</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Kang, Tae‐Ho</creator><creator>Yoon, Goo</creator><creator>Kang, In‐A</creator><creator>Oh, Ha‐Na</creator><creator>Chae, Jung‐Il</creator><creator>Shim, Jung‐Hyun</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4062-4016</orcidid></search><sort><creationdate>201712</creationdate><title>Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells</title><author>Kang, Tae‐Ho ; Yoon, Goo ; Kang, In‐A ; Oh, Ha‐Na ; Chae, Jung‐Il ; Shim, Jung‐Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3498-871fd48bb8c220a95ca650848f6644296adfd95aa2635f41325d78da43cc29e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenosine diphosphate</topic><topic>Annexin V</topic><topic>Anticancer properties</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bacteria</topic><topic>Biological effects</topic><topic>Biological Products - chemistry</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>CCAAT/enhancer-binding protein</topic><topic>Cell death</topic><topic>Cell proliferation</topic><topic>Chalcones - chemistry</topic><topic>death receptor</topic><topic>Death receptors</topic><topic>Glycyrrhiza</topic><topic>Homology</topic><topic>human skin cancer</topic><topic>Humans</topic><topic>Inflammation</topic><topic>licochalcone B</topic><topic>Lymphocytes B</topic><topic>Melanoma</topic><topic>Melanoma - drug therapy</topic><topic>Melanoma - pathology</topic><topic>Melanoma, Cutaneous Malignant</topic><topic>Membrane potential</topic><topic>Mitochondria</topic><topic>mitochondrial membrane potential</topic><topic>Organic compounds</topic><topic>Pharmacology</topic><topic>Proteins</topic><topic>Receptors</topic><topic>Ribose</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - pathology</topic><topic>specificity protein 1</topic><topic>Squamous cell carcinoma</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Tae‐Ho</creatorcontrib><creatorcontrib>Yoon, Goo</creatorcontrib><creatorcontrib>Kang, In‐A</creatorcontrib><creatorcontrib>Oh, Ha‐Na</creatorcontrib><creatorcontrib>Chae, Jung‐Il</creatorcontrib><creatorcontrib>Shim, Jung‐Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Tae‐Ho</au><au>Yoon, Goo</au><au>Kang, In‐A</au><au>Oh, Ha‐Na</au><au>Chae, Jung‐Il</au><au>Shim, Jung‐Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2017-12</date><risdate>2017</risdate><volume>31</volume><issue>12</issue><spage>1858</spage><epage>1867</epage><pages>1858-1867</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic compounds including retrochalcones. Potential pharmacological properties of Lico B include anti‐inflammatory, anti‐bacterial, anti‐oxidant, and anti‐cancer activities. However, its biological effects on melanoma and squamous cell carcinoma (SCC) are unknown. Based on these known facts, this study investigated the role of Lico B in apoptosis, through the extrinsic and intrinsic pathways and additional regulation of specificity protein 1 in human skin cancer cell lines. Annexin V/7‐aminoactinomycin D staining, western blot analysis, mitochondrial membrane potential assay, and an anchorage‐independent cell transformation assay demonstrated that Lico B treatment of human melanoma and SCC cells significantly inhibited cell proliferation and induced apoptotic cell death. More specifically, Lico B induced apoptosis through the regulation of specificity protein 1 and apoptosis‐related proteins including CCAAT/enhancer‐binding protein homologous protein, death receptors, and poly (ADP‐ribose) polymerase. These results indicate that Lico B has apoptotic effect on A375 and A431 skin cancer cells, suggesting the potential value of Lico B for the treatment of human melanoma and SCC. Copyright © 2017 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29027311</pmid><doi>10.1002/ptr.5928</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4062-4016</orcidid></addata></record> |
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| subjects | Adenosine diphosphate Annexin V Anticancer properties Apoptosis Apoptosis - drug effects Bacteria Biological effects Biological Products - chemistry Cancer Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology CCAAT/enhancer-binding protein Cell death Cell proliferation Chalcones - chemistry death receptor Death receptors Glycyrrhiza Homology human skin cancer Humans Inflammation licochalcone B Lymphocytes B Melanoma Melanoma - drug therapy Melanoma - pathology Melanoma, Cutaneous Malignant Membrane potential Mitochondria mitochondrial membrane potential Organic compounds Pharmacology Proteins Receptors Ribose Skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - pathology specificity protein 1 Squamous cell carcinoma Tumor cell lines |
| title | Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells |
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