Microstructural MRI Basis of the Cognitive Functions in Patients with Spinocerebellar Ataxia Type 2

•Cerebellar microstructural damage affects Middle and Superior Cerebellar Peduncle in SCA2 patients.•Diffusivity changes predominantly reflect the white matter degeneration typically observed in cerebellar atrophies.•Diffusivity changes may reflect a dysregulation of cerebello-cerebral interaction.•...

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Veröffentlicht in:	Neuroscience 2017-12, Vol.366, p.44-53
Hauptverfasser:	Olivito, G., Lupo, M., Iacobacci, C., Clausi, S., Romano, S., Masciullo, M., Molinari, M., Cercignani, M., Bozzali, M., Leggio, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged cerebellar peduncles cerebellum Cerebellum - diagnostic imaging Cerebellum - pathology Cognition Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging DTI Female Humans Male Middle Aged Neuropsychological Tests Spinocerebellar Ataxias - diagnostic imaging Spinocerebellar Ataxias - pathology Spinocerebellar Ataxias - psychology tractography white matter White Matter - diagnostic imaging White Matter - pathology
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