Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women
•Vitamin D (VD) deficiency could play an important role in the prognostic features of breast cancer.•Serum level of 25 hydroxyvitamin D was measured in all patients up to 20days post-diagnosis.•Sufficient VD levels were detected in 33.8% of patients, while deficient levels in 66.2% of cases.•VD defi...
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| description | •Vitamin D (VD) deficiency could play an important role in the prognostic features of breast cancer.•Serum level of 25 hydroxyvitamin D was measured in all patients up to 20days post-diagnosis.•Sufficient VD levels were detected in 33.8% of patients, while deficient levels in 66.2% of cases.•VD deficiency was associated with positive axillary lymph node status, negative estrogen receptor and high Ki-67.•All cases of triple negative were detected in VD deficient women.
This study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45–75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included. Clinical and anthropometric data were collected. Serum level of 25 hydroxyvitamin D [25(OH)D] was measured in all patients until 20days after breast cancer diagnosis, and was classified as normal (≥30ng/mL), insufficiency (20–29ng/mL) and deficiency ( |
| doi_str_mv | 10.1016/j.jsbmb.2017.10.009 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1951565295</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960076017302789</els_id><sourcerecordid>1951565295</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-1250c5ebdcec790e256e84bc3c9a82d0bf597df8996e7ee9b6684c49ddd7551b3</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EotvCJ0BClrhw2WWcxI594IAKFKRKvbRcLf-ZgKNNHGynVb99vd3CgQMna0a_eX56j5A3DHYMmPgw7sZsJ7trgPV1swNQz8iGyV5tWdPAc7IBJWALvYATcprzCABty_qX5KRR0DIh5YYMP0IxU5jpZ-pxCC7g7O5pyNTkHF0wBT29C-UXXWJM1CY0uVBnZoeJLin-nGMuwdEBTVkTZlqVlrqacI6LWbPZ07tYh1fkxWD2GV8_vWfk5uuX6_Nv28uri-_nny63rmubUn1zcBytd-h6BdhwgbKzrnXKyMaDHbjq_SCVEtgjKiuE7FynvPc958y2Z-T9Ubd6-71iLnoK2eF-b2aMa9ZMccYFbxSv6Lt_0DGuaa7uKiWhk0wwUan2SLkUc0446CWFyaR7zUAfatCjfqxBH2o4LGsN9ertk_ZqJ_R_b_7kXoGPRwBrGLcBk86P0aMPCV3RPob_fvAAqBybNg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1980481616</pqid></control><display><type>article</type><title>Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>de Sousa Almeida-Filho, Benedito ; De Luca Vespoli, Heloisa ; Pessoa, Eduardo Carvalho ; Machado, Murilo ; Nahas-Neto, Jorge ; Nahas, Eliana Aguiar Petri</creator><creatorcontrib>de Sousa Almeida-Filho, Benedito ; De Luca Vespoli, Heloisa ; Pessoa, Eduardo Carvalho ; Machado, Murilo ; Nahas-Neto, Jorge ; Nahas, Eliana Aguiar Petri</creatorcontrib><description>•Vitamin D (VD) deficiency could play an important role in the prognostic features of breast cancer.•Serum level of 25 hydroxyvitamin D was measured in all patients up to 20days post-diagnosis.•Sufficient VD levels were detected in 33.8% of patients, while deficient levels in 66.2% of cases.•VD deficiency was associated with positive axillary lymph node status, negative estrogen receptor and high Ki-67.•All cases of triple negative were detected in VD deficient women.
This study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45–75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included. Clinical and anthropometric data were collected. Serum level of 25 hydroxyvitamin D [25(OH)D] was measured in all patients until 20days after breast cancer diagnosis, and was classified as normal (≥30ng/mL), insufficiency (20–29ng/mL) and deficiency (<20ng/mL). Data on breast cancer (histopathological type, grade, tumor stage, lymph node status), hormone status (estrogen receptor, ER, progesterone receptor, PR), human epidermal growth factor receptor type 2 (HER2) and epithelial proliferative activity (Ki-67) were collected. For statistical analysis, the t-student test, the Gamma Distribution (asymmetric variables), the chi-square test and the logistic regression (OR-odds ratio) were used. The median 25(OH)D level was 25.8ng/mL (range 12.0–59.2ng/mL). Sufficient vitamin D levels were detected in 65 patients (33.9%), whereas insufficient levels in 92 patients (47.9%), and deficient levels in 35 patients (18.2%). Participants with insufficient and deficient 25(OH)D levels had a higher proportion of tumors with a high grade and locally advanced and metastatic disease, more positive lymph node, a lower proportion of ER, PR positives tumors and higher Ki-67(p<0.05). Patients with normal vitamin D had a higher frequency of luminal A (47.7%) and luminal B (32.2%) tumors when compared to patients with vitamin D insufficiency or deficiency. Furthermore, all cases of triple negative were detected in women with low VD levels. Multivariate analysis, after adjusting for age, time since menopause and BMI, showed that insufficient and deficient level of vitamin D were significantly associated with negative estrogen receptor (OR 3.77 CI 95% 1.76–8.09 and OR 3.99 CI 95% 1.83–8.68), high Ki-67 (OR 2.50, CI 95% 1.35–4.63, and OR 2.62, CI 95% 1.40–4.98), and positive axillary lymph node status (OR 1.59, CI 95% 1.03–2.33, and OR 1.58, CI 95% 1.02–2.92) respectively. In Brazilian postmenopausal women with breast cancer, there was an association between vitamin D insufficiency or deficiency and tumors with worse prognostic features. Low vitamin D levels were shown to be a risk factor for ER negative tumors, with positive axilla and a higher rate of cell proliferation.</description><identifier>ISSN: 0960-0760</identifier><identifier>EISSN: 1879-1220</identifier><identifier>DOI: 10.1016/j.jsbmb.2017.10.009</identifier><identifier>PMID: 29031688</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>25-Hydroxyvitamin D ; Aged ; Amenorrhea ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - epidemiology ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cell proliferation ; Cross-Sectional Studies ; Diagnosis ; Epidermal growth factor ; ErbB-2 protein ; Estrogen receptors ; Female ; Humans ; Immunohistochemical profile ; Ki-67 Antigen - metabolism ; Lymph ; Lymph nodes ; Menopause ; Metastases ; Middle Aged ; Multivariate analysis ; Odds Ratio ; Post-menopause ; Postmenopausal women ; Postmenopause - blood ; Postmenopause - metabolism ; Progesterone ; Prognosis ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Sexually transmitted diseases ; Statistical analysis ; STD ; Studies ; Tumor Burden ; Tumors ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - metabolism ; Vitamin deficiency</subject><ispartof>The Journal of steroid biochemistry and molecular biology, 2017-11, Vol.174, p.284-289</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Nov 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-1250c5ebdcec790e256e84bc3c9a82d0bf597df8996e7ee9b6684c49ddd7551b3</citedby><cites>FETCH-LOGICAL-c432t-1250c5ebdcec790e256e84bc3c9a82d0bf597df8996e7ee9b6684c49ddd7551b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960076017302789$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29031688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Sousa Almeida-Filho, Benedito</creatorcontrib><creatorcontrib>De Luca Vespoli, Heloisa</creatorcontrib><creatorcontrib>Pessoa, Eduardo Carvalho</creatorcontrib><creatorcontrib>Machado, Murilo</creatorcontrib><creatorcontrib>Nahas-Neto, Jorge</creatorcontrib><creatorcontrib>Nahas, Eliana Aguiar Petri</creatorcontrib><title>Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women</title><title>The Journal of steroid biochemistry and molecular biology</title><addtitle>J Steroid Biochem Mol Biol</addtitle><description>•Vitamin D (VD) deficiency could play an important role in the prognostic features of breast cancer.•Serum level of 25 hydroxyvitamin D was measured in all patients up to 20days post-diagnosis.•Sufficient VD levels were detected in 33.8% of patients, while deficient levels in 66.2% of cases.•VD deficiency was associated with positive axillary lymph node status, negative estrogen receptor and high Ki-67.•All cases of triple negative were detected in VD deficient women.
This study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45–75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included. Clinical and anthropometric data were collected. Serum level of 25 hydroxyvitamin D [25(OH)D] was measured in all patients until 20days after breast cancer diagnosis, and was classified as normal (≥30ng/mL), insufficiency (20–29ng/mL) and deficiency (<20ng/mL). Data on breast cancer (histopathological type, grade, tumor stage, lymph node status), hormone status (estrogen receptor, ER, progesterone receptor, PR), human epidermal growth factor receptor type 2 (HER2) and epithelial proliferative activity (Ki-67) were collected. For statistical analysis, the t-student test, the Gamma Distribution (asymmetric variables), the chi-square test and the logistic regression (OR-odds ratio) were used. The median 25(OH)D level was 25.8ng/mL (range 12.0–59.2ng/mL). Sufficient vitamin D levels were detected in 65 patients (33.9%), whereas insufficient levels in 92 patients (47.9%), and deficient levels in 35 patients (18.2%). Participants with insufficient and deficient 25(OH)D levels had a higher proportion of tumors with a high grade and locally advanced and metastatic disease, more positive lymph node, a lower proportion of ER, PR positives tumors and higher Ki-67(p<0.05). Patients with normal vitamin D had a higher frequency of luminal A (47.7%) and luminal B (32.2%) tumors when compared to patients with vitamin D insufficiency or deficiency. Furthermore, all cases of triple negative were detected in women with low VD levels. Multivariate analysis, after adjusting for age, time since menopause and BMI, showed that insufficient and deficient level of vitamin D were significantly associated with negative estrogen receptor (OR 3.77 CI 95% 1.76–8.09 and OR 3.99 CI 95% 1.83–8.68), high Ki-67 (OR 2.50, CI 95% 1.35–4.63, and OR 2.62, CI 95% 1.40–4.98), and positive axillary lymph node status (OR 1.59, CI 95% 1.03–2.33, and OR 1.58, CI 95% 1.02–2.92) respectively. In Brazilian postmenopausal women with breast cancer, there was an association between vitamin D insufficiency or deficiency and tumors with worse prognostic features. Low vitamin D levels were shown to be a risk factor for ER negative tumors, with positive axilla and a higher rate of cell proliferation.</description><subject>25-Hydroxyvitamin D</subject><subject>Aged</subject><subject>Amenorrhea</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell proliferation</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis</subject><subject>Epidermal growth factor</subject><subject>ErbB-2 protein</subject><subject>Estrogen receptors</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemical profile</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Lymph</subject><subject>Lymph nodes</subject><subject>Menopause</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Odds Ratio</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Postmenopause - blood</subject><subject>Postmenopause - metabolism</subject><subject>Progesterone</subject><subject>Prognosis</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Sexually transmitted diseases</subject><subject>Statistical analysis</subject><subject>STD</subject><subject>Studies</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - metabolism</subject><subject>Vitamin deficiency</subject><issn>0960-0760</issn><issn>1879-1220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EotvCJ0BClrhw2WWcxI594IAKFKRKvbRcLf-ZgKNNHGynVb99vd3CgQMna0a_eX56j5A3DHYMmPgw7sZsJ7trgPV1swNQz8iGyV5tWdPAc7IBJWALvYATcprzCABty_qX5KRR0DIh5YYMP0IxU5jpZ-pxCC7g7O5pyNTkHF0wBT29C-UXXWJM1CY0uVBnZoeJLin-nGMuwdEBTVkTZlqVlrqacI6LWbPZ07tYh1fkxWD2GV8_vWfk5uuX6_Nv28uri-_nny63rmubUn1zcBytd-h6BdhwgbKzrnXKyMaDHbjq_SCVEtgjKiuE7FynvPc958y2Z-T9Ubd6-71iLnoK2eF-b2aMa9ZMccYFbxSv6Lt_0DGuaa7uKiWhk0wwUan2SLkUc0446CWFyaR7zUAfatCjfqxBH2o4LGsN9ertk_ZqJ_R_b_7kXoGPRwBrGLcBk86P0aMPCV3RPob_fvAAqBybNg</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>de Sousa Almeida-Filho, Benedito</creator><creator>De Luca Vespoli, Heloisa</creator><creator>Pessoa, Eduardo Carvalho</creator><creator>Machado, Murilo</creator><creator>Nahas-Neto, Jorge</creator><creator>Nahas, Eliana Aguiar Petri</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women</title><author>de Sousa Almeida-Filho, Benedito ; De Luca Vespoli, Heloisa ; Pessoa, Eduardo Carvalho ; Machado, Murilo ; Nahas-Neto, Jorge ; Nahas, Eliana Aguiar Petri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-1250c5ebdcec790e256e84bc3c9a82d0bf597df8996e7ee9b6684c49ddd7551b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Aged</topic><topic>Amenorrhea</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell proliferation</topic><topic>Cross-Sectional Studies</topic><topic>Diagnosis</topic><topic>Epidermal growth factor</topic><topic>ErbB-2 protein</topic><topic>Estrogen receptors</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemical profile</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Lymph</topic><topic>Lymph nodes</topic><topic>Menopause</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Odds Ratio</topic><topic>Post-menopause</topic><topic>Postmenopausal women</topic><topic>Postmenopause - blood</topic><topic>Postmenopause - metabolism</topic><topic>Progesterone</topic><topic>Prognosis</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Sexually transmitted diseases</topic><topic>Statistical analysis</topic><topic>STD</topic><topic>Studies</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - metabolism</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Sousa Almeida-Filho, Benedito</creatorcontrib><creatorcontrib>De Luca Vespoli, Heloisa</creatorcontrib><creatorcontrib>Pessoa, Eduardo Carvalho</creatorcontrib><creatorcontrib>Machado, Murilo</creatorcontrib><creatorcontrib>Nahas-Neto, Jorge</creatorcontrib><creatorcontrib>Nahas, Eliana Aguiar Petri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Sousa Almeida-Filho, Benedito</au><au>De Luca Vespoli, Heloisa</au><au>Pessoa, Eduardo Carvalho</au><au>Machado, Murilo</au><au>Nahas-Neto, Jorge</au><au>Nahas, Eliana Aguiar Petri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women</atitle><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle><addtitle>J Steroid Biochem Mol Biol</addtitle><date>2017-11</date><risdate>2017</risdate><volume>174</volume><spage>284</spage><epage>289</epage><pages>284-289</pages><issn>0960-0760</issn><eissn>1879-1220</eissn><abstract>•Vitamin D (VD) deficiency could play an important role in the prognostic features of breast cancer.•Serum level of 25 hydroxyvitamin D was measured in all patients up to 20days post-diagnosis.•Sufficient VD levels were detected in 33.8% of patients, while deficient levels in 66.2% of cases.•VD deficiency was associated with positive axillary lymph node status, negative estrogen receptor and high Ki-67.•All cases of triple negative were detected in VD deficient women.
This study aimed to evaluate the association between pretreatment vitamin D (VD) deficiency with breast cancer prognostic features in Brazilian postmenopausal women. An analytical cross sectional study was conducted with 192 women, aged 45–75 years, attended at University Hospital. Women with recent diagnosis of breast cancer, in amenorrhea >12months and age ≥45 years, without medication use or clinical conditions that interfere with VD values were included. Clinical and anthropometric data were collected. Serum level of 25 hydroxyvitamin D [25(OH)D] was measured in all patients until 20days after breast cancer diagnosis, and was classified as normal (≥30ng/mL), insufficiency (20–29ng/mL) and deficiency (<20ng/mL). Data on breast cancer (histopathological type, grade, tumor stage, lymph node status), hormone status (estrogen receptor, ER, progesterone receptor, PR), human epidermal growth factor receptor type 2 (HER2) and epithelial proliferative activity (Ki-67) were collected. For statistical analysis, the t-student test, the Gamma Distribution (asymmetric variables), the chi-square test and the logistic regression (OR-odds ratio) were used. The median 25(OH)D level was 25.8ng/mL (range 12.0–59.2ng/mL). Sufficient vitamin D levels were detected in 65 patients (33.9%), whereas insufficient levels in 92 patients (47.9%), and deficient levels in 35 patients (18.2%). Participants with insufficient and deficient 25(OH)D levels had a higher proportion of tumors with a high grade and locally advanced and metastatic disease, more positive lymph node, a lower proportion of ER, PR positives tumors and higher Ki-67(p<0.05). Patients with normal vitamin D had a higher frequency of luminal A (47.7%) and luminal B (32.2%) tumors when compared to patients with vitamin D insufficiency or deficiency. Furthermore, all cases of triple negative were detected in women with low VD levels. Multivariate analysis, after adjusting for age, time since menopause and BMI, showed that insufficient and deficient level of vitamin D were significantly associated with negative estrogen receptor (OR 3.77 CI 95% 1.76–8.09 and OR 3.99 CI 95% 1.83–8.68), high Ki-67 (OR 2.50, CI 95% 1.35–4.63, and OR 2.62, CI 95% 1.40–4.98), and positive axillary lymph node status (OR 1.59, CI 95% 1.03–2.33, and OR 1.58, CI 95% 1.02–2.92) respectively. In Brazilian postmenopausal women with breast cancer, there was an association between vitamin D insufficiency or deficiency and tumors with worse prognostic features. Low vitamin D levels were shown to be a risk factor for ER negative tumors, with positive axilla and a higher rate of cell proliferation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29031688</pmid><doi>10.1016/j.jsbmb.2017.10.009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 25-Hydroxyvitamin D Aged Amenorrhea Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - blood Breast Neoplasms - epidemiology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell proliferation Cross-Sectional Studies Diagnosis Epidermal growth factor ErbB-2 protein Estrogen receptors Female Humans Immunohistochemical profile Ki-67 Antigen - metabolism Lymph Lymph nodes Menopause Metastases Middle Aged Multivariate analysis Odds Ratio Post-menopause Postmenopausal women Postmenopause - blood Postmenopause - metabolism Progesterone Prognosis Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Sexually transmitted diseases Statistical analysis STD Studies Tumor Burden Tumors Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - epidemiology Vitamin D Deficiency - metabolism Vitamin deficiency |
| title | Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women |
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