Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia‑1 Protein

The environment-sensitive probe 2 with turn-on switch for Mcl-1 protein was developed herein. After careful evaluation, this small molecule fluorescent probe revealed a selective binding affinity with Mcl-1 protein with a K i value of 2.6 μM and can be well applied to imaging Mcl-1 protein or detect...

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Veröffentlicht in:	Analytical chemistry (Washington) 2017-11, Vol.89 (21), p.11173-11177
Hauptverfasser:	Liu, Tingting, Gao, Yuqi, Zhang, Xiaomeng, Wan, Yichao, Du, Lupei, Fang, Hao, Li, Minyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Bcl-2 protein Cell Line, Tumor Cells Chemistry Dansyl Compounds - chemical synthesis Dansyl Compounds - chemistry Dansyl Compounds - toxicity Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - toxicity HEK293 Cells Humans Immunofluorescence Indoles - chemical synthesis Indoles - chemistry Indoles - toxicity Leukemia Mcl-1 protein Microscopy, Confocal - methods Microscopy, Fluorescence - methods Molecular Docking Simulation Myeloid Cell Leukemia Sequence 1 Protein - analysis Myeloid Cell Leukemia Sequence 1 Protein - chemistry Proteins Selective binding
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