Untargeted GC‐MS Metabolomics Reveals Changes in the Metabolite Dynamics of Industrial Scale Batch Fermentations of Streptoccoccus thermophilus Broth

An industrial scale biomass production using batch or fed‐batch fermentations usually optimized by selection of bacterial strains, tuning fermentation media, feeding strategy, and temperature. However, in‐depth investigation of the biomass metabolome during the production may reveal new knowledge fo...

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Veröffentlicht in:	Biotechnology journal 2017-10, Vol.12 (10), p.n/a
Hauptverfasser:	Khakimov, Bekzod, Christiansen, Lene D., Heins, Anna‐Lena, Sørensen, Klavs M., Schöller, Charlotte, Clausen, Anders, Skov, Thomas, Gernaey, Krist V., Engelsen, Søren B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance ASCA Batch Cell Culture Techniques - methods Biomass Culture Media - chemistry Culture Media - pharmacology Fermentation Gas Chromatography-Mass Spectrometry - methods GC‐MS Industrial Microbiology - methods Metabolome Metabolomics PARAFAC2 Streptococci Streptococcus - drug effects Streptococcus - growth & development Streptococcus - metabolism Time Factors Yeast extract Yeasts - chemistry
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