Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52bp deletion and the ASXL1 p.R693X mutation
Peripheral blood sample was donated by a 61years old female patient diagnosed with acute myeloid leukemia secondary to a primary myelofibrosis harboring the 52-bp deletion in the CALR gene (c.1092_1143del, p.L367fs*46) and the R693X mutation in the ASXL1 gene (c.2077C>T, p.R693X). CD34+ cells wer...
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Veröffentlicht in: | Stem cell research 2017-10, Vol.24, p.16-20 |
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creator | Gomez Limia, Cintia E. Devalle, Sylvie Reis, Marcelo Sochacki, Jaroslaw Carneiro, Mayra Madeiro da Costa, Rodrigo D'Andrea, Mariana Padilha, Telma Zalcberg, Ilana R. Solza, Cristiana Daumas, Adelmo Rehen, Stevens Monte-Mór, Bárbara Bonamino, Martín H. |
description | Peripheral blood sample was donated by a 61years old female patient diagnosed with acute myeloid leukemia secondary to a primary myelofibrosis harboring the 52-bp deletion in the CALR gene (c.1092_1143del, p.L367fs*46) and the R693X mutation in the ASXL1 gene (c.2077C>T, p.R693X). CD34+ cells were isolated from the sample and subjected to the reprogramming procedure by using the Sendai virus carrying the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. iPS colonies generated retained the original mutations and displayed all the features of bona fide iPS cells. |
doi_str_mv | 10.1016/j.scr.2017.08.006 |
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CD34+ cells were isolated from the sample and subjected to the reprogramming procedure by using the Sendai virus carrying the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. iPS colonies generated retained the original mutations and displayed all the features of bona fide iPS cells.</description><identifier>ISSN: 1873-5061</identifier><identifier>EISSN: 1876-7753</identifier><identifier>DOI: 10.1016/j.scr.2017.08.006</identifier><identifier>PMID: 29034885</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Cell Differentiation ; Cell Line ; Female ; Humans ; Induced Pluripotent Stem Cells - metabolism ; Leukemia, Myeloid, Acute - pathology ; Leukemia, Myeloid, Acute - therapy ; Male ; Middle Aged ; Mutation ; Primary Myelofibrosis - pathology ; Primary Myelofibrosis - therapy</subject><ispartof>Stem cell research, 2017-10, Vol.24, p.16-20</ispartof><rights>2017 The Authors</rights><rights>Copyright © 2017 The Authors. 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CD34+ cells were isolated from the sample and subjected to the reprogramming procedure by using the Sendai virus carrying the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. iPS colonies generated retained the original mutations and displayed all the features of bona fide iPS cells.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cell Line</subject><subject>Female</subject><subject>Humans</subject><subject>Induced Pluripotent Stem Cells - metabolism</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Primary Myelofibrosis - pathology</subject><subject>Primary Myelofibrosis - therapy</subject><issn>1873-5061</issn><issn>1876-7753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9ks9u1DAQxiMEon_gAbggH8shwY7XjiNOVQUFaSVQC1JvlmOPWS9JHGxnpeV9-x44zcLJlufnb2a-maJ4Q3BFMOHv91XUoaoxaSosKoz5s-KciIaXTcPo86c7LRnm5Ky4iHGPMWtrUb8szuoW040Q7Lx4vIURgkrOj0iNBumdCkonCO7P-ugtUmg3D2pEbjSzBoOmfg5u8gnGhGKCAV25b_fvkIa-R70bAZn8_ZBBG_yQVZHScwI0HKH3zqAe5l8wOIWmnGHRgIPvD278ufJTcIMKxxW3rgs-uoi0CuG4MGkH6OZ6e4dY3U05Uw__a19C1_cPW4Km6o639AENc3rq4lXxwqo-wuvTeVn8-PTx-83ncvv19ktWK4FgwUrettR2uFGUbRqimwZTbm3HrdLaKKVV3dZaWGYEa4GC2HSGg1WMClJ3LHt6WVytulPwv2eISQ4uLr6oEfwcJWkZYZwSwjP69oTO3QBGntqW_0aTgQ8rALngg4Mgo8525QG4ADpJ450kWC6LIPc5FuSyCBILmReB_gUQtqmw</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Gomez Limia, Cintia E.</creator><creator>Devalle, Sylvie</creator><creator>Reis, Marcelo</creator><creator>Sochacki, Jaroslaw</creator><creator>Carneiro, Mayra</creator><creator>Madeiro da Costa, Rodrigo</creator><creator>D'Andrea, Mariana</creator><creator>Padilha, Telma</creator><creator>Zalcberg, Ilana R.</creator><creator>Solza, Cristiana</creator><creator>Daumas, Adelmo</creator><creator>Rehen, Stevens</creator><creator>Monte-Mór, Bárbara</creator><creator>Bonamino, Martín H.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4599-9490</orcidid></search><sort><creationdate>201710</creationdate><title>Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52bp deletion and the ASXL1 p.R693X mutation</title><author>Gomez Limia, Cintia E. ; Devalle, Sylvie ; Reis, Marcelo ; Sochacki, Jaroslaw ; Carneiro, Mayra ; Madeiro da Costa, Rodrigo ; D'Andrea, Mariana ; Padilha, Telma ; Zalcberg, Ilana R. ; Solza, Cristiana ; Daumas, Adelmo ; Rehen, Stevens ; Monte-Mór, Bárbara ; Bonamino, Martín H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1085-6993fb07a35471c77036ffb6faccdaaca292c8f5d859e3e84bd6efa53812b5903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cell Line</topic><topic>Female</topic><topic>Humans</topic><topic>Induced Pluripotent Stem Cells - metabolism</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Primary Myelofibrosis - pathology</topic><topic>Primary Myelofibrosis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez Limia, Cintia E.</creatorcontrib><creatorcontrib>Devalle, Sylvie</creatorcontrib><creatorcontrib>Reis, Marcelo</creatorcontrib><creatorcontrib>Sochacki, Jaroslaw</creatorcontrib><creatorcontrib>Carneiro, Mayra</creatorcontrib><creatorcontrib>Madeiro da Costa, Rodrigo</creatorcontrib><creatorcontrib>D'Andrea, Mariana</creatorcontrib><creatorcontrib>Padilha, Telma</creatorcontrib><creatorcontrib>Zalcberg, Ilana R.</creatorcontrib><creatorcontrib>Solza, Cristiana</creatorcontrib><creatorcontrib>Daumas, Adelmo</creatorcontrib><creatorcontrib>Rehen, Stevens</creatorcontrib><creatorcontrib>Monte-Mór, Bárbara</creatorcontrib><creatorcontrib>Bonamino, Martín H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Stem cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomez Limia, Cintia E.</au><au>Devalle, Sylvie</au><au>Reis, Marcelo</au><au>Sochacki, Jaroslaw</au><au>Carneiro, Mayra</au><au>Madeiro da Costa, Rodrigo</au><au>D'Andrea, Mariana</au><au>Padilha, Telma</au><au>Zalcberg, Ilana R.</au><au>Solza, Cristiana</au><au>Daumas, Adelmo</au><au>Rehen, Stevens</au><au>Monte-Mór, Bárbara</au><au>Bonamino, Martín H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52bp deletion and the ASXL1 p.R693X mutation</atitle><jtitle>Stem cell research</jtitle><addtitle>Stem Cell Res</addtitle><date>2017-10</date><risdate>2017</risdate><volume>24</volume><spage>16</spage><epage>20</epage><pages>16-20</pages><issn>1873-5061</issn><eissn>1876-7753</eissn><abstract>Peripheral blood sample was donated by a 61years old female patient diagnosed with acute myeloid leukemia secondary to a primary myelofibrosis harboring the 52-bp deletion in the CALR gene (c.1092_1143del, p.L367fs*46) and the R693X mutation in the ASXL1 gene (c.2077C>T, p.R693X). 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subjects | Animals Cell Differentiation Cell Line Female Humans Induced Pluripotent Stem Cells - metabolism Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Male Middle Aged Mutation Primary Myelofibrosis - pathology Primary Myelofibrosis - therapy |
title | Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52bp deletion and the ASXL1 p.R693X mutation |
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