Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52bp deletion and the ASXL1 p.R693X mutation

Peripheral blood sample was donated by a 61years old female patient diagnosed with acute myeloid leukemia secondary to a primary myelofibrosis harboring the 52-bp deletion in the CALR gene (c.1092_1143del, p.L367fs*46) and the R693X mutation in the ASXL1 gene (c.2077C>T, p.R693X). CD34+ cells wer...

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Veröffentlicht in:Stem cell research 2017-10, Vol.24, p.16-20
Hauptverfasser: Gomez Limia, Cintia E., Devalle, Sylvie, Reis, Marcelo, Sochacki, Jaroslaw, Carneiro, Mayra, Madeiro da Costa, Rodrigo, D'Andrea, Mariana, Padilha, Telma, Zalcberg, Ilana R., Solza, Cristiana, Daumas, Adelmo, Rehen, Stevens, Monte-Mór, Bárbara, Bonamino, Martín H.
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container_start_page 16
container_title Stem cell research
container_volume 24
creator Gomez Limia, Cintia E.
Devalle, Sylvie
Reis, Marcelo
Sochacki, Jaroslaw
Carneiro, Mayra
Madeiro da Costa, Rodrigo
D'Andrea, Mariana
Padilha, Telma
Zalcberg, Ilana R.
Solza, Cristiana
Daumas, Adelmo
Rehen, Stevens
Monte-Mór, Bárbara
Bonamino, Martín H.
description Peripheral blood sample was donated by a 61years old female patient diagnosed with acute myeloid leukemia secondary to a primary myelofibrosis harboring the 52-bp deletion in the CALR gene (c.1092_1143del, p.L367fs*46) and the R693X mutation in the ASXL1 gene (c.2077C>T, p.R693X). CD34+ cells were isolated from the sample and subjected to the reprogramming procedure by using the Sendai virus carrying the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. iPS colonies generated retained the original mutations and displayed all the features of bona fide iPS cells.
doi_str_mv 10.1016/j.scr.2017.08.006
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CD34+ cells were isolated from the sample and subjected to the reprogramming procedure by using the Sendai virus carrying the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. iPS colonies generated retained the original mutations and displayed all the features of bona fide iPS cells.</description><identifier>ISSN: 1873-5061</identifier><identifier>EISSN: 1876-7753</identifier><identifier>DOI: 10.1016/j.scr.2017.08.006</identifier><identifier>PMID: 29034885</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Cell Differentiation ; Cell Line ; Female ; Humans ; Induced Pluripotent Stem Cells - metabolism ; Leukemia, Myeloid, Acute - pathology ; Leukemia, Myeloid, Acute - therapy ; Male ; Middle Aged ; Mutation ; Primary Myelofibrosis - pathology ; Primary Myelofibrosis - therapy</subject><ispartof>Stem cell research, 2017-10, Vol.24, p.16-20</ispartof><rights>2017 The Authors</rights><rights>Copyright © 2017 The Authors. 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subjects Animals
Cell Differentiation
Cell Line
Female
Humans
Induced Pluripotent Stem Cells - metabolism
Leukemia, Myeloid, Acute - pathology
Leukemia, Myeloid, Acute - therapy
Male
Middle Aged
Mutation
Primary Myelofibrosis - pathology
Primary Myelofibrosis - therapy
title Generation and characterization of a human induced pluripotent stem (iPS) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the CALR 52bp deletion and the ASXL1 p.R693X mutation
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