Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

An effective blood-based method for the diagnosis and prognosis of hepatocellular carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying cancer-specific genetic and epigenetic aberrations may enable a noninvasive ‘liquid biopsy’ for diagnosis and monitoring of cancer. He...

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Veröffentlicht in:	Nature materials 2017-11, Vol.16 (11), p.1155-1161
Hauptverfasser:	Xu, Rui-hua, Wei, Wei, Krawczyk, Michal, Wang, Wenqiu, Luo, Huiyan, Flagg, Ken, Yi, Shaohua, Shi, William, Quan, Qingli, Li, Kang, Zheng, Lianghong, Zhang, Heng, Caughey, Bennett A., Zhao, Qi, Hou, Jiayi, Zhang, Runze, Xu, Yanxin, Cai, Huimin, Li, Gen, Hou, Rui, Zhong, Zheng, Lin, Danni, Fu, Xin, Zhu, Jie, Duan, Yaou, Yu, Meixing, Ying, Binwu, Zhang, Wengeng, Wang, Juan, Zhang, Edward, Zhang, Charlotte, Li, Oulan, Guo, Rongping, Carter, Hannah, Zhu, Jian-kang, Hao, Xiaoke, Zhang, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2210 631/67/1857 Aberration Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biomaterials Blood Cancer Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Condensed Matter Physics Deoxyribonucleic acid Diagnosis Diagnostic systems DNA DNA Methylation Female Hepatology Humans Leukocytes Liver cancer Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - genetics Male Markers Materials Science Mathematical models Medical diagnosis Medical prognosis Models, Biological Nanotechnology Optical and Electronic Materials Prediction models Prognosis Tumors
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