Maternal n-6 and n-3 fatty acid status during pregnancy is related to infant heart rate and heart rate variability: An exploratory study
Early life heart rate (HR) and heart rate variability (HRV) reflect autonomic system maturation. Intervention with n-3 long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy favorably affects fetal HR and HRV, complementing previous observations for n-3 LCPUFA intervention during infancy....
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2017-11, Vol.126, p.117-125 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Drewery, M.L. Gaitán, A.V. Spedale, S.B. Monlezun, C.J. Miketínas, D.C. Lammi-Keefe, C.J. |
| description | Early life heart rate (HR) and heart rate variability (HRV) reflect autonomic system maturation. Intervention with n-3 long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy favorably affects fetal HR and HRV, complementing previous observations for n-3 LCPUFA intervention during infancy. The relationship between maternal fatty acid status during pregnancy and infant HR/HRV has not previously been assessed. The aim of this study was to explore associations between maternal n-6 and n-3 fatty acid status during pregnancy and infant HR and HRV at 2 weeks, 4 months, and 6 months of age using linear regression models. Maternal n-3 fatty acids were inversely related to infant HR and positively related to HRV. Conversely, maternal n-6 fatty acids were positively related to infant HR and inversely related to HRV. These data build on existing literature evidencing a role for n-3 fatty acids in accelerating autonomic development and link n-6 fatty acids to HR/HRV.
•Relationships between maternal fatty acids and infant HR and HRV were assessed.•Maternal n-6 fatty acids were inversely related to infant HRV.•Maternal n-3 fatty acids were positively related to infant HRV.•Data evidences a role for n-3 fatty acids in accelerating autonomic development.•These relationships have not been previously assessed. |
| doi_str_mv | 10.1016/j.plefa.2017.09.003 |
| format | Article |
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•Relationships between maternal fatty acids and infant HR and HRV were assessed.•Maternal n-6 fatty acids were inversely related to infant HRV.•Maternal n-3 fatty acids were positively related to infant HRV.•Data evidences a role for n-3 fatty acids in accelerating autonomic development.•These relationships have not been previously assessed.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2017.09.003</identifier><identifier>PMID: 29031389</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Arachidonic acid ; Arachidonic Acid - blood ; Autonomic nervous system ; Docosahexaenoic acid ; Docosahexaenoic Acids - blood ; Fatty Acids, Omega-3 - blood ; Fatty Acids, Omega-6 - blood ; Female ; Heart rate ; Heart rate variability ; Heart Rate, Fetal ; Humans ; Infant ; Infant, Newborn ; Maternal-Fetal Relations ; n-3 long chain polyunsaturated fatty acids ; Pregnancy</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2017-11, Vol.126, p.117-125</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-c25bd5db162bbac0e8dbf837efb2c7ac1605e21dbfa14afbe0ac0a124bd940173</citedby><cites>FETCH-LOGICAL-c404t-c25bd5db162bbac0e8dbf837efb2c7ac1605e21dbfa14afbe0ac0a124bd940173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0952327817301436$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29031389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drewery, M.L.</creatorcontrib><creatorcontrib>Gaitán, A.V.</creatorcontrib><creatorcontrib>Spedale, S.B.</creatorcontrib><creatorcontrib>Monlezun, C.J.</creatorcontrib><creatorcontrib>Miketínas, D.C.</creatorcontrib><creatorcontrib>Lammi-Keefe, C.J.</creatorcontrib><title>Maternal n-6 and n-3 fatty acid status during pregnancy is related to infant heart rate and heart rate variability: An exploratory study</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>Early life heart rate (HR) and heart rate variability (HRV) reflect autonomic system maturation. Intervention with n-3 long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy favorably affects fetal HR and HRV, complementing previous observations for n-3 LCPUFA intervention during infancy. The relationship between maternal fatty acid status during pregnancy and infant HR/HRV has not previously been assessed. The aim of this study was to explore associations between maternal n-6 and n-3 fatty acid status during pregnancy and infant HR and HRV at 2 weeks, 4 months, and 6 months of age using linear regression models. Maternal n-3 fatty acids were inversely related to infant HR and positively related to HRV. Conversely, maternal n-6 fatty acids were positively related to infant HR and inversely related to HRV. These data build on existing literature evidencing a role for n-3 fatty acids in accelerating autonomic development and link n-6 fatty acids to HR/HRV.
•Relationships between maternal fatty acids and infant HR and HRV were assessed.•Maternal n-6 fatty acids were inversely related to infant HRV.•Maternal n-3 fatty acids were positively related to infant HRV.•Data evidences a role for n-3 fatty acids in accelerating autonomic development.•These relationships have not been previously assessed.</description><subject>Adult</subject><subject>Arachidonic acid</subject><subject>Arachidonic Acid - blood</subject><subject>Autonomic nervous system</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - blood</subject><subject>Fatty Acids, Omega-3 - blood</subject><subject>Fatty Acids, Omega-6 - blood</subject><subject>Female</subject><subject>Heart rate</subject><subject>Heart rate variability</subject><subject>Heart Rate, Fetal</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Maternal-Fetal Relations</subject><subject>n-3 long chain polyunsaturated fatty acids</subject><subject>Pregnancy</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1TAQtBCIPgq_AAn5yCVhbSd5CRKHquJLKuICZ2ttb4qf8pxgO1XzD_jZuH0FceK02t2ZHe0MYy8F1AJE9-ZQLxONWEsQ-xqGGkA9YjvRKlnJXqrHbAdDKysl9_0Ze5bSAQCkEM1TdiYHUEL1w479-oKZYsCJh6rjGFypio-Y88bResdTxrwm7tbowzVfIl0HDHbjPvFIUyE7nmfuw4gh8x-EMfNYpven_mlvMHo0fvJ5e8svAqfbZZrLZo5bkVjd9pw9GXFK9OKhnrPvH95_u_xUXX39-Pny4qqyDTS5srI1rnVGdNIYtEC9M2Ov9jQaafdoRQctSVGGKBocDUEBoZCNcUNTjFLn7PXp7hLnnyulrI8-WZomDDSvSYuhFW1XDOwLVJ2gNs4pRRr1Ev0R46YF6LsI9EHfR6DvItAw6BJBYb16EFjNkdxfzh_PC-DdCUDlzRtPUSfrKVhyPpLN2s3-vwK_AXI3mzI</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Drewery, M.L.</creator><creator>Gaitán, A.V.</creator><creator>Spedale, S.B.</creator><creator>Monlezun, C.J.</creator><creator>Miketínas, D.C.</creator><creator>Lammi-Keefe, C.J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Maternal n-6 and n-3 fatty acid status during pregnancy is related to infant heart rate and heart rate variability: An exploratory study</title><author>Drewery, M.L. ; Gaitán, A.V. ; Spedale, S.B. ; Monlezun, C.J. ; Miketínas, D.C. ; Lammi-Keefe, C.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-c25bd5db162bbac0e8dbf837efb2c7ac1605e21dbfa14afbe0ac0a124bd940173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Arachidonic acid</topic><topic>Arachidonic Acid - blood</topic><topic>Autonomic nervous system</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - blood</topic><topic>Fatty Acids, Omega-3 - blood</topic><topic>Fatty Acids, Omega-6 - blood</topic><topic>Female</topic><topic>Heart rate</topic><topic>Heart rate variability</topic><topic>Heart Rate, Fetal</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Maternal-Fetal Relations</topic><topic>n-3 long chain polyunsaturated fatty acids</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drewery, M.L.</creatorcontrib><creatorcontrib>Gaitán, A.V.</creatorcontrib><creatorcontrib>Spedale, S.B.</creatorcontrib><creatorcontrib>Monlezun, C.J.</creatorcontrib><creatorcontrib>Miketínas, D.C.</creatorcontrib><creatorcontrib>Lammi-Keefe, C.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drewery, M.L.</au><au>Gaitán, A.V.</au><au>Spedale, S.B.</au><au>Monlezun, C.J.</au><au>Miketínas, D.C.</au><au>Lammi-Keefe, C.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal n-6 and n-3 fatty acid status during pregnancy is related to infant heart rate and heart rate variability: An exploratory study</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2017-11</date><risdate>2017</risdate><volume>126</volume><spage>117</spage><epage>125</epage><pages>117-125</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Early life heart rate (HR) and heart rate variability (HRV) reflect autonomic system maturation. Intervention with n-3 long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy favorably affects fetal HR and HRV, complementing previous observations for n-3 LCPUFA intervention during infancy. The relationship between maternal fatty acid status during pregnancy and infant HR/HRV has not previously been assessed. The aim of this study was to explore associations between maternal n-6 and n-3 fatty acid status during pregnancy and infant HR and HRV at 2 weeks, 4 months, and 6 months of age using linear regression models. Maternal n-3 fatty acids were inversely related to infant HR and positively related to HRV. Conversely, maternal n-6 fatty acids were positively related to infant HR and inversely related to HRV. These data build on existing literature evidencing a role for n-3 fatty acids in accelerating autonomic development and link n-6 fatty acids to HR/HRV.
•Relationships between maternal fatty acids and infant HR and HRV were assessed.•Maternal n-6 fatty acids were inversely related to infant HRV.•Maternal n-3 fatty acids were positively related to infant HRV.•Data evidences a role for n-3 fatty acids in accelerating autonomic development.•These relationships have not been previously assessed.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>29031389</pmid><doi>10.1016/j.plefa.2017.09.003</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arachidonic acid Arachidonic Acid - blood Autonomic nervous system Docosahexaenoic acid Docosahexaenoic Acids - blood Fatty Acids, Omega-3 - blood Fatty Acids, Omega-6 - blood Female Heart rate Heart rate variability Heart Rate, Fetal Humans Infant Infant, Newborn Maternal-Fetal Relations n-3 long chain polyunsaturated fatty acids Pregnancy |
| title | Maternal n-6 and n-3 fatty acid status during pregnancy is related to infant heart rate and heart rate variability: An exploratory study |
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