Peri-operative blood transfusion for resected colon cancer: Practice patterns and outcomes in a population-based study
•28% of resected colon cancer patients received a transfusion.•Transfusion is associated with age, female sex, advanced disease and open resection.•Transfusion is associated with worse overall survival and cancer specific survival. Literature suggests that peri-operative blood transfusion among pati...
Gespeichert in:
| Veröffentlicht in: | Cancer epidemiology 2017-12, Vol.51, p.35-40 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 40 |
|---|---|
| container_issue | |
| container_start_page | 35 |
| container_title | Cancer epidemiology |
| container_volume | 51 |
| creator | Patel, Sunil V. Brennan, Kelly E. Nanji, Sulaiman Karim, Safiya Merchant, Shaila Booth, Christopher M. |
| description | •28% of resected colon cancer patients received a transfusion.•Transfusion is associated with age, female sex, advanced disease and open resection.•Transfusion is associated with worse overall survival and cancer specific survival.
Literature suggests that peri-operative blood transfusion among patients with resected colon cancer may be associated with inferior long-term survival. The study objective was to characterize this association in our population.
This is a retrospective cohort study using the population-based Ontario Cancer Registry (2002–2008). Pathology reports were obtained for a 25% random sample of all cases and constituted the study population. Log binomial regression was used to identify factors associated with transfusion. Cox proportional hazards model explored the association between transfusion and cancer specific survival (CSS) and overall survival (OS).
The study population included 7198 patients: 18% stage I, 36% stage II, 40% stage III, and 6% stage IV. Twenty-eight percent of patients were transfused. Factors independently associated with transfusion included advanced age (p |
| doi_str_mv | 10.1016/j.canep.2017.10.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1951560773</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1877782117301625</els_id><sourcerecordid>1951560773</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-f15232910e8f79c13aaa9d0851e27b735c71ab88d13371e69b0fcdccfa5138163</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVJadK0n6AQBLn04q3GwpYUyCGE_oNAc2ihNyFLY9DitRxJXsi372w3zSGHniQev3kzvMfYBxAbENB_2m68m3HZtAIUKRsh-lfsDLRSjdLy98nzv4VT9raULQE9QPeGnbZGyFaCOWP7e8yxSQtmV-Me-TClFHjNbi7jWmKa-Zgyz1jQVwzcp4kk2usxX_H77HyNHvniasU8F-7mwNNafdph4XHmji9pWSfyTnMzuEIWpa7h8R17Pbqp4Pun95z9-vL55-235u7H1--3N3eNl1rVZoSula0BgXpUxoN0zpkgdAfYqkHJzitwg9YBpFSAvRnE6IP3o-tAaujlOft49F1yelixVLuLxeM0UXJpLRZMB10vlJKEXr5At2nNM11HVG8M2fWaKHmkfE6lZBztkuPO5UcLwh5qsVv7txZ7qOUgUuo0dfHkvQ47DM8z_3og4PoIIIWxj5ht8REp5RAzJW9Div9d8AdluaBI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1969981668</pqid></control><display><type>article</type><title>Peri-operative blood transfusion for resected colon cancer: Practice patterns and outcomes in a population-based study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Patel, Sunil V. ; Brennan, Kelly E. ; Nanji, Sulaiman ; Karim, Safiya ; Merchant, Shaila ; Booth, Christopher M.</creator><creatorcontrib>Patel, Sunil V. ; Brennan, Kelly E. ; Nanji, Sulaiman ; Karim, Safiya ; Merchant, Shaila ; Booth, Christopher M.</creatorcontrib><description>•28% of resected colon cancer patients received a transfusion.•Transfusion is associated with age, female sex, advanced disease and open resection.•Transfusion is associated with worse overall survival and cancer specific survival.
Literature suggests that peri-operative blood transfusion among patients with resected colon cancer may be associated with inferior long-term survival. The study objective was to characterize this association in our population.
This is a retrospective cohort study using the population-based Ontario Cancer Registry (2002–2008). Pathology reports were obtained for a 25% random sample of all cases and constituted the study population. Log binomial regression was used to identify factors associated with transfusion. Cox proportional hazards model explored the association between transfusion and cancer specific survival (CSS) and overall survival (OS).
The study population included 7198 patients: 18% stage I, 36% stage II, 40% stage III, and 6% stage IV. Twenty-eight percent of patients were transfused. Factors independently associated with transfusion included advanced age (p<0.001), female sex (p<0.001), greater comorbidity (p<0.001), more advanced disease (p<0.001) and open surgical resection (p<0.001). Transfusion was associated with inferior CSS (HR 1.51, 95% CI 1.38–1.65) and OS (HR 1.52, 95% CI 1.41–1.63), after adjusting for important confounders.
Peri-operative transfusion rates among patients with colon cancer have decreased over time. Transfusion is associated with inferior long-term CSS and OS.</description><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2017.10.006</identifier><identifier>PMID: 29032319</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Blood ; Blood transfusion ; Blood Transfusion - methods ; Blood transfusions ; Cancer ; Cancer specific survival ; Cancer surgery ; Chemotherapy ; Cohort Studies ; Colon ; Colon cancer ; Colonic Neoplasms - pathology ; Colonic Neoplasms - surgery ; Colonic Neoplasms - therapy ; Colorectal cancer ; Epidemiology ; Family income ; Female ; Health risk assessment ; Humans ; Income distribution ; Male ; Medical prognosis ; Middle Aged ; Overall survival ; Population ; Population studies ; Population-based studies ; Retrospective Studies ; Socioeconomic factors ; Surgeons ; Survival analysis ; Transfusion ; Transplants & implants ; Treatment Outcome ; Young Adult</subject><ispartof>Cancer epidemiology, 2017-12, Vol.51, p.35-40</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-f15232910e8f79c13aaa9d0851e27b735c71ab88d13371e69b0fcdccfa5138163</citedby><cites>FETCH-LOGICAL-c387t-f15232910e8f79c13aaa9d0851e27b735c71ab88d13371e69b0fcdccfa5138163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1877782117301625$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29032319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Sunil V.</creatorcontrib><creatorcontrib>Brennan, Kelly E.</creatorcontrib><creatorcontrib>Nanji, Sulaiman</creatorcontrib><creatorcontrib>Karim, Safiya</creatorcontrib><creatorcontrib>Merchant, Shaila</creatorcontrib><creatorcontrib>Booth, Christopher M.</creatorcontrib><title>Peri-operative blood transfusion for resected colon cancer: Practice patterns and outcomes in a population-based study</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>•28% of resected colon cancer patients received a transfusion.•Transfusion is associated with age, female sex, advanced disease and open resection.•Transfusion is associated with worse overall survival and cancer specific survival.
Literature suggests that peri-operative blood transfusion among patients with resected colon cancer may be associated with inferior long-term survival. The study objective was to characterize this association in our population.
This is a retrospective cohort study using the population-based Ontario Cancer Registry (2002–2008). Pathology reports were obtained for a 25% random sample of all cases and constituted the study population. Log binomial regression was used to identify factors associated with transfusion. Cox proportional hazards model explored the association between transfusion and cancer specific survival (CSS) and overall survival (OS).
The study population included 7198 patients: 18% stage I, 36% stage II, 40% stage III, and 6% stage IV. Twenty-eight percent of patients were transfused. Factors independently associated with transfusion included advanced age (p<0.001), female sex (p<0.001), greater comorbidity (p<0.001), more advanced disease (p<0.001) and open surgical resection (p<0.001). Transfusion was associated with inferior CSS (HR 1.51, 95% CI 1.38–1.65) and OS (HR 1.52, 95% CI 1.41–1.63), after adjusting for important confounders.
Peri-operative transfusion rates among patients with colon cancer have decreased over time. Transfusion is associated with inferior long-term CSS and OS.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood</subject><subject>Blood transfusion</subject><subject>Blood Transfusion - methods</subject><subject>Blood transfusions</subject><subject>Cancer</subject><subject>Cancer specific survival</subject><subject>Cancer surgery</subject><subject>Chemotherapy</subject><subject>Cohort Studies</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - surgery</subject><subject>Colonic Neoplasms - therapy</subject><subject>Colorectal cancer</subject><subject>Epidemiology</subject><subject>Family income</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Income distribution</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Overall survival</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Retrospective Studies</subject><subject>Socioeconomic factors</subject><subject>Surgeons</subject><subject>Survival analysis</subject><subject>Transfusion</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1877-7821</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9r3DAQxUVJadK0n6AQBLn04q3GwpYUyCGE_oNAc2ihNyFLY9DitRxJXsi372w3zSGHniQev3kzvMfYBxAbENB_2m68m3HZtAIUKRsh-lfsDLRSjdLy98nzv4VT9raULQE9QPeGnbZGyFaCOWP7e8yxSQtmV-Me-TClFHjNbi7jWmKa-Zgyz1jQVwzcp4kk2usxX_H77HyNHvniasU8F-7mwNNafdph4XHmji9pWSfyTnMzuEIWpa7h8R17Pbqp4Pun95z9-vL55-235u7H1--3N3eNl1rVZoSula0BgXpUxoN0zpkgdAfYqkHJzitwg9YBpFSAvRnE6IP3o-tAaujlOft49F1yelixVLuLxeM0UXJpLRZMB10vlJKEXr5At2nNM11HVG8M2fWaKHmkfE6lZBztkuPO5UcLwh5qsVv7txZ7qOUgUuo0dfHkvQ47DM8z_3og4PoIIIWxj5ht8REp5RAzJW9Div9d8AdluaBI</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Patel, Sunil V.</creator><creator>Brennan, Kelly E.</creator><creator>Nanji, Sulaiman</creator><creator>Karim, Safiya</creator><creator>Merchant, Shaila</creator><creator>Booth, Christopher M.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>Peri-operative blood transfusion for resected colon cancer: Practice patterns and outcomes in a population-based study</title><author>Patel, Sunil V. ; Brennan, Kelly E. ; Nanji, Sulaiman ; Karim, Safiya ; Merchant, Shaila ; Booth, Christopher M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-f15232910e8f79c13aaa9d0851e27b735c71ab88d13371e69b0fcdccfa5138163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood</topic><topic>Blood transfusion</topic><topic>Blood Transfusion - methods</topic><topic>Blood transfusions</topic><topic>Cancer</topic><topic>Cancer specific survival</topic><topic>Cancer surgery</topic><topic>Chemotherapy</topic><topic>Cohort Studies</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Neoplasms - surgery</topic><topic>Colonic Neoplasms - therapy</topic><topic>Colorectal cancer</topic><topic>Epidemiology</topic><topic>Family income</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Income distribution</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Overall survival</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Retrospective Studies</topic><topic>Socioeconomic factors</topic><topic>Surgeons</topic><topic>Survival analysis</topic><topic>Transfusion</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Sunil V.</creatorcontrib><creatorcontrib>Brennan, Kelly E.</creatorcontrib><creatorcontrib>Nanji, Sulaiman</creatorcontrib><creatorcontrib>Karim, Safiya</creatorcontrib><creatorcontrib>Merchant, Shaila</creatorcontrib><creatorcontrib>Booth, Christopher M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Sunil V.</au><au>Brennan, Kelly E.</au><au>Nanji, Sulaiman</au><au>Karim, Safiya</au><au>Merchant, Shaila</au><au>Booth, Christopher M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peri-operative blood transfusion for resected colon cancer: Practice patterns and outcomes in a population-based study</atitle><jtitle>Cancer epidemiology</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>51</volume><spage>35</spage><epage>40</epage><pages>35-40</pages><issn>1877-7821</issn><eissn>1877-783X</eissn><abstract>•28% of resected colon cancer patients received a transfusion.•Transfusion is associated with age, female sex, advanced disease and open resection.•Transfusion is associated with worse overall survival and cancer specific survival.
Literature suggests that peri-operative blood transfusion among patients with resected colon cancer may be associated with inferior long-term survival. The study objective was to characterize this association in our population.
This is a retrospective cohort study using the population-based Ontario Cancer Registry (2002–2008). Pathology reports were obtained for a 25% random sample of all cases and constituted the study population. Log binomial regression was used to identify factors associated with transfusion. Cox proportional hazards model explored the association between transfusion and cancer specific survival (CSS) and overall survival (OS).
The study population included 7198 patients: 18% stage I, 36% stage II, 40% stage III, and 6% stage IV. Twenty-eight percent of patients were transfused. Factors independently associated with transfusion included advanced age (p<0.001), female sex (p<0.001), greater comorbidity (p<0.001), more advanced disease (p<0.001) and open surgical resection (p<0.001). Transfusion was associated with inferior CSS (HR 1.51, 95% CI 1.38–1.65) and OS (HR 1.52, 95% CI 1.41–1.63), after adjusting for important confounders.
Peri-operative transfusion rates among patients with colon cancer have decreased over time. Transfusion is associated with inferior long-term CSS and OS.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>29032319</pmid><doi>10.1016/j.canep.2017.10.006</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1877-7821 |
| ispartof | Cancer epidemiology, 2017-12, Vol.51, p.35-40 |
| issn | 1877-7821 1877-783X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1951560773 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Blood Blood transfusion Blood Transfusion - methods Blood transfusions Cancer Cancer specific survival Cancer surgery Chemotherapy Cohort Studies Colon Colon cancer Colonic Neoplasms - pathology Colonic Neoplasms - surgery Colonic Neoplasms - therapy Colorectal cancer Epidemiology Family income Female Health risk assessment Humans Income distribution Male Medical prognosis Middle Aged Overall survival Population Population studies Population-based studies Retrospective Studies Socioeconomic factors Surgeons Survival analysis Transfusion Transplants & implants Treatment Outcome Young Adult |
| title | Peri-operative blood transfusion for resected colon cancer: Practice patterns and outcomes in a population-based study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T09%3A48%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peri-operative%20blood%20transfusion%20for%20resected%20colon%20cancer:%20Practice%20patterns%20and%20outcomes%20in%20a%20population-based%20study&rft.jtitle=Cancer%20epidemiology&rft.au=Patel,%20Sunil%20V.&rft.date=2017-12-01&rft.volume=51&rft.spage=35&rft.epage=40&rft.pages=35-40&rft.issn=1877-7821&rft.eissn=1877-783X&rft_id=info:doi/10.1016/j.canep.2017.10.006&rft_dat=%3Cproquest_cross%3E1951560773%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1969981668&rft_id=info:pmid/29032319&rft_els_id=S1877782117301625&rfr_iscdi=true |