Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status
Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA an...
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| Veröffentlicht in: | Journal of fish diseases 2018-02, Vol.41 (2), p.263-268 |
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| creator | Baldissera, M D Souza, C F Doleski, P H Monteiro, S G Silva, A S Baldisserotto, B |
| description | Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals. Moreover, the seric XO activity increased in infected animals compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS). Based on this evidence, the downregulation of seric ADA activity exerts an anti‐inflammatory profile, contributing to restricting the inflammatory process. The most important finding is that upregulation of seric XO activity leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Moreover, uric acid induces the release of pro‐inflammatory and pro‐oxidative mediators, such NOx and ROS, which contribute directly to disease pathogenesis. In summary, the upregulation of XO activity may be considered a pathway involved in NOx and ROS production in silver catfish infected with I. multifiliis. |
| doi_str_mv | 10.1111/jfd.12709 |
| format | Article |
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Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals. Moreover, the seric XO activity increased in infected animals compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS). Based on this evidence, the downregulation of seric ADA activity exerts an anti‐inflammatory profile, contributing to restricting the inflammatory process. The most important finding is that upregulation of seric XO activity leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Moreover, uric acid induces the release of pro‐inflammatory and pro‐oxidative mediators, such NOx and ROS, which contribute directly to disease pathogenesis. In summary, the upregulation of XO activity may be considered a pathway involved in NOx and ROS production in silver catfish infected with I. multifiliis.</description><identifier>ISSN: 0140-7775</identifier><identifier>EISSN: 1365-2761</identifier><identifier>DOI: 10.1111/jfd.12709</identifier><identifier>PMID: 29027691</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adenosine ; Adenosine deaminase ; Animals ; Catfish ; Freshwater fishes ; Ichthyophthirius multifiliis ; immune response ; Infectious diseases ; Metabolites ; Nitric oxide ; Nitrogen compounds ; Nitrogen oxides ; Pathogenesis ; Reactive oxygen species ; Serum ; Uric acid ; white spot disease ; Xanthine oxidase</subject><ispartof>Journal of fish diseases, 2018-02, Vol.41 (2), p.263-268</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-6a2d4b6b1c04e2a8820b1d01c373e681dfe82080ceb386dc8e3b3d31060e4e463</citedby><cites>FETCH-LOGICAL-c3539-6a2d4b6b1c04e2a8820b1d01c373e681dfe82080ceb386dc8e3b3d31060e4e463</cites><orcidid>0000-0001-9978-0454 ; 0000-0002-8770-0100 ; 0000-0002-3280-8528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjfd.12709$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjfd.12709$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29027691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baldissera, M D</creatorcontrib><creatorcontrib>Souza, C F</creatorcontrib><creatorcontrib>Doleski, P H</creatorcontrib><creatorcontrib>Monteiro, S G</creatorcontrib><creatorcontrib>Silva, A S</creatorcontrib><creatorcontrib>Baldisserotto, B</creatorcontrib><title>Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status</title><title>Journal of fish diseases</title><addtitle>J Fish Dis</addtitle><description>Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals. Moreover, the seric XO activity increased in infected animals compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS). Based on this evidence, the downregulation of seric ADA activity exerts an anti‐inflammatory profile, contributing to restricting the inflammatory process. The most important finding is that upregulation of seric XO activity leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Moreover, uric acid induces the release of pro‐inflammatory and pro‐oxidative mediators, such NOx and ROS, which contribute directly to disease pathogenesis. In summary, the upregulation of XO activity may be considered a pathway involved in NOx and ROS production in silver catfish infected with I. multifiliis.</description><subject>Adenosine</subject><subject>Adenosine deaminase</subject><subject>Animals</subject><subject>Catfish</subject><subject>Freshwater fishes</subject><subject>Ichthyophthirius multifiliis</subject><subject>immune response</subject><subject>Infectious diseases</subject><subject>Metabolites</subject><subject>Nitric oxide</subject><subject>Nitrogen compounds</subject><subject>Nitrogen oxides</subject><subject>Pathogenesis</subject><subject>Reactive oxygen species</subject><subject>Serum</subject><subject>Uric acid</subject><subject>white spot disease</subject><subject>Xanthine oxidase</subject><issn>0140-7775</issn><issn>1365-2761</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kUFv1DAQhS0EokvhwB9AlrjAIa0dJ07CDbUUWlXiQDlHjj1RZuU4i-20Tf8f_wtvtnBAqg9jaebTe096hLzl7ISnd7rtzQnPK9Y8IxsuZJnlleTPyYbxgmVVVZVH5FUIW8Z4VXL5khzlDUtIwzfk9w_w80iVATcFdEANqBGdCkCVM_ReuTjs19M9mnWpI95iRAgUHQ1ob8FTrWKPYaBOxdkra5d060FHMPQO40Av9RCHZdqliR7nQMfZRuzRIoZP9GaAPW9ncDoZ9TQOkJzAPSxjspncelXjqOLklzXWmiYFARpi8gyvyYte2QBvHv9j8vPiy83Zt-z6-9fLs8_XmRalaDKpclN0suOaFZCrus5Zxw3jWlQCZM1ND2lVMw2dqKXRNYhOGMGZZFBAIcUx-XDQ3fnp1wwhtiMGDdYqB9McWt6UvJSMiSah7_9Dt9PsXUqXqFqyRlQVS9THA6X9FIKHvt15HJVfWs7afbdt6rZdu03su0fFuRvB_CP_lpmA0wNwhxaWp5Xaq4vzg-QfeAezFg</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Baldissera, M D</creator><creator>Souza, C F</creator><creator>Doleski, P H</creator><creator>Monteiro, S G</creator><creator>Silva, A S</creator><creator>Baldisserotto, B</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TN</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9978-0454</orcidid><orcidid>https://orcid.org/0000-0002-8770-0100</orcidid><orcidid>https://orcid.org/0000-0002-3280-8528</orcidid></search><sort><creationdate>201802</creationdate><title>Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status</title><author>Baldissera, M D ; Souza, C F ; Doleski, P H ; Monteiro, S G ; Silva, A S ; Baldisserotto, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-6a2d4b6b1c04e2a8820b1d01c373e681dfe82080ceb386dc8e3b3d31060e4e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenosine</topic><topic>Adenosine deaminase</topic><topic>Animals</topic><topic>Catfish</topic><topic>Freshwater fishes</topic><topic>Ichthyophthirius multifiliis</topic><topic>immune response</topic><topic>Infectious diseases</topic><topic>Metabolites</topic><topic>Nitric oxide</topic><topic>Nitrogen compounds</topic><topic>Nitrogen oxides</topic><topic>Pathogenesis</topic><topic>Reactive oxygen species</topic><topic>Serum</topic><topic>Uric acid</topic><topic>white spot disease</topic><topic>Xanthine oxidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baldissera, M D</creatorcontrib><creatorcontrib>Souza, C F</creatorcontrib><creatorcontrib>Doleski, P H</creatorcontrib><creatorcontrib>Monteiro, S G</creatorcontrib><creatorcontrib>Silva, A S</creatorcontrib><creatorcontrib>Baldisserotto, B</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Oceanic Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of fish diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baldissera, M D</au><au>Souza, C F</au><au>Doleski, P H</au><au>Monteiro, S G</au><au>Silva, A S</au><au>Baldisserotto, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status</atitle><jtitle>Journal of fish diseases</jtitle><addtitle>J Fish Dis</addtitle><date>2018-02</date><risdate>2018</risdate><volume>41</volume><issue>2</issue><spage>263</spage><epage>268</epage><pages>263-268</pages><issn>0140-7775</issn><eissn>1365-2761</eissn><abstract>Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals. Moreover, the seric XO activity increased in infected animals compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS). Based on this evidence, the downregulation of seric ADA activity exerts an anti‐inflammatory profile, contributing to restricting the inflammatory process. The most important finding is that upregulation of seric XO activity leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Moreover, uric acid induces the release of pro‐inflammatory and pro‐oxidative mediators, such NOx and ROS, which contribute directly to disease pathogenesis. In summary, the upregulation of XO activity may be considered a pathway involved in NOx and ROS production in silver catfish infected with I. multifiliis.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>29027691</pmid><doi>10.1111/jfd.12709</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9978-0454</orcidid><orcidid>https://orcid.org/0000-0002-8770-0100</orcidid><orcidid>https://orcid.org/0000-0002-3280-8528</orcidid></addata></record> |
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| ispartof | Journal of fish diseases, 2018-02, Vol.41 (2), p.263-268 |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | Adenosine Adenosine deaminase Animals Catfish Freshwater fishes Ichthyophthirius multifiliis immune response Infectious diseases Metabolites Nitric oxide Nitrogen compounds Nitrogen oxides Pathogenesis Reactive oxygen species Serum Uric acid white spot disease Xanthine oxidase |
| title | Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status |
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