Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats

Previous studies in our lab have shown that tetramethylpyrazine (TMP) could effectively attenuate disuse induced muscle atrophy. In order to screening out the optimal dose of tetramethylpyrazine (TMP) for protection against disuse induced muscle atrophy in hindlimb unloading (HLU) rats, in this stud...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-12, Vol.96, p.513-523
Hauptverfasser:	Zhang, Jie, Li, Yang, Li, Guangyue, Ma, Xiufeng, Wang, Huiping, Goswami, Nandu, Hinghofer-Szalkay, Helmut, Chang, Hui, Gao, Yunfang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calpain - physiology Calpains Disuse atrophy Dose-Response Relationship, Drug Female Hindlimb Suspension - methods Hindlimb Suspension - physiology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle functional properties Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscular Atrophy - drug therapy Muscular Atrophy - prevention & control Pyrazines - administration & dosage Rats Rats, Sprague-Dawley Tetramethylpyrazine Vasodilator Agents - administration & dosage
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!