Upregulation of vascular endothelial growth factor (VEGF), its role in progression and prognosis of non-small cell lung carcinoma
•Significant association of VEGF mRNA with advanced clinical stages and adenocarcinoma histology in NSCLC.•VEGF mRNA (−ΔCT ≥10) was found to be associated with NSCLC.•Quantity of VEGF mRNA can be useful to predict the progression of NSCLC. Elevated VEGF mRNA (−ΔCT) was significantly associated with...
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| Veröffentlicht in: | Cancer genetics 2017-10, Vol.216-217, p.67-73 |
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| container_title | Cancer genetics |
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| creator | Naikoo, Niyaz A. Rasool, Roohi Shah, Sonaullah Ahangar, A.G. Siddiqi, Mushtaq A. Shah, Zafar A. |
| description | •Significant association of VEGF mRNA with advanced clinical stages and adenocarcinoma histology in NSCLC.•VEGF mRNA (−ΔCT ≥10) was found to be associated with NSCLC.•Quantity of VEGF mRNA can be useful to predict the progression of NSCLC.
Elevated VEGF mRNA (−ΔCT) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan–Meier analysis showed that NSCLC patients with higher VEGF mRNA (−ΔCT ≥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of −ΔCT |
| doi_str_mv | 10.1016/j.cancergen.2017.07.005 |
| format | Article |
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Elevated VEGF mRNA (−ΔCT) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan–Meier analysis showed that NSCLC patients with higher VEGF mRNA (−ΔCT ≥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of −ΔCT <10 (P < 0.001). The multivariable analysis confirmed that patients with higher VEGF mRNA levels, as well as with adenocarcinoma and advanced stages, were independent predictors of a poorer survival. However, only the histology of adenocarcinoma remained a significant prognostic factor of a shorter postoperative relapse in the multivariable model. Quantity of VEGF mRNA can be used as a prognosis factor to predict shorter overall survival in patients with NSCLC.</description><identifier>ISSN: 2210-7762</identifier><identifier>EISSN: 2210-7770</identifier><identifier>DOI: 10.1016/j.cancergen.2017.07.005</identifier><identifier>PMID: 29025597</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - surgery ; Case-Control Studies ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Linear Models ; Lung Neoplasms - genetics ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Multivariate Analysis ; NSCLC ; Postoperative Care ; Prognosis ; progression ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Up-Regulation - genetics ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism ; VEGF</subject><ispartof>Cancer genetics, 2017-10, Vol.216-217, p.67-73</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-28d89706af06085caea14ac89b170c533751ada2a6beab8fe88a79689766e3d33</citedby><cites>FETCH-LOGICAL-c371t-28d89706af06085caea14ac89b170c533751ada2a6beab8fe88a79689766e3d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cancergen.2017.07.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29025597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naikoo, Niyaz A.</creatorcontrib><creatorcontrib>Rasool, Roohi</creatorcontrib><creatorcontrib>Shah, Sonaullah</creatorcontrib><creatorcontrib>Ahangar, A.G.</creatorcontrib><creatorcontrib>Siddiqi, Mushtaq A.</creatorcontrib><creatorcontrib>Shah, Zafar A.</creatorcontrib><creatorcontrib>Dil-Afroze</creatorcontrib><title>Upregulation of vascular endothelial growth factor (VEGF), its role in progression and prognosis of non-small cell lung carcinoma</title><title>Cancer genetics</title><addtitle>Cancer Genet</addtitle><description>•Significant association of VEGF mRNA with advanced clinical stages and adenocarcinoma histology in NSCLC.•VEGF mRNA (−ΔCT ≥10) was found to be associated with NSCLC.•Quantity of VEGF mRNA can be useful to predict the progression of NSCLC.
Elevated VEGF mRNA (−ΔCT) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan–Meier analysis showed that NSCLC patients with higher VEGF mRNA (−ΔCT ≥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of −ΔCT <10 (P < 0.001). The multivariable analysis confirmed that patients with higher VEGF mRNA levels, as well as with adenocarcinoma and advanced stages, were independent predictors of a poorer survival. However, only the histology of adenocarcinoma remained a significant prognostic factor of a shorter postoperative relapse in the multivariable model. Quantity of VEGF mRNA can be used as a prognosis factor to predict shorter overall survival in patients with NSCLC.</description><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Case-Control Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Linear Models</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>NSCLC</subject><subject>Postoperative Care</subject><subject>Prognosis</subject><subject>progression</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Up-Regulation - genetics</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>VEGF</subject><issn>2210-7762</issn><issn>2210-7770</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1P3DAQtaoiQJS_QH2kEtmOk3XsHBECWgmpl8LVmnUmwavE3toJqMf-c5wu3Wutke2R3nvz8Rj7LGAlQNRftyuL3lLsya9KEGoFOUB-YKdlKaBQSsHHw78uT9h5SlvIZy1Bq-qYnZQNlFI26pT9edxF6ucBJxc8Dx1_wWRzGjn5NkzPNDgceB_D6_TMO7RTiPzy6fb-7ssVd1PiMQzEnee7GPpIKS0q6Nu_uQ_JpUXTB1-kEYeBW8rXMPueW4zW-TDiJ3bU4ZDo_P09Y493tz9vvhUPP-6_31w_FLZSYipK3epGQY0d1KClRUKxRqubjVBgZVUpKbDFEusN4UZ3pDWqps6cuqaqraozdrnXza39milNZnRp6Qc9hTkZ0Ughpa7EOkPVHmpjSClSZ3bRjRh_GwFmscBszcECs1hgIAfIzLx4LzJvRmoPvH8Lz4DrPYDyqC-OoknWUZZqXSQ7mTa4_xZ5Awt8nUo</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Naikoo, Niyaz A.</creator><creator>Rasool, Roohi</creator><creator>Shah, Sonaullah</creator><creator>Ahangar, A.G.</creator><creator>Siddiqi, Mushtaq A.</creator><creator>Shah, Zafar A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Upregulation of vascular endothelial growth factor (VEGF), its role in progression and prognosis of non-small cell lung carcinoma</title><author>Naikoo, Niyaz A. ; Rasool, Roohi ; Shah, Sonaullah ; Ahangar, A.G. ; Siddiqi, Mushtaq A. ; Shah, Zafar A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-28d89706af06085caea14ac89b170c533751ada2a6beab8fe88a79689766e3d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Case-Control Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Linear Models</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>NSCLC</topic><topic>Postoperative Care</topic><topic>Prognosis</topic><topic>progression</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Up-Regulation - genetics</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naikoo, Niyaz A.</creatorcontrib><creatorcontrib>Rasool, Roohi</creatorcontrib><creatorcontrib>Shah, Sonaullah</creatorcontrib><creatorcontrib>Ahangar, A.G.</creatorcontrib><creatorcontrib>Siddiqi, Mushtaq A.</creatorcontrib><creatorcontrib>Shah, Zafar A.</creatorcontrib><creatorcontrib>Dil-Afroze</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naikoo, Niyaz A.</au><au>Rasool, Roohi</au><au>Shah, Sonaullah</au><au>Ahangar, A.G.</au><au>Siddiqi, Mushtaq A.</au><au>Shah, Zafar A.</au><aucorp>Dil-Afroze</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of vascular endothelial growth factor (VEGF), its role in progression and prognosis of non-small cell lung carcinoma</atitle><jtitle>Cancer genetics</jtitle><addtitle>Cancer Genet</addtitle><date>2017-10</date><risdate>2017</risdate><volume>216-217</volume><spage>67</spage><epage>73</epage><pages>67-73</pages><issn>2210-7762</issn><eissn>2210-7770</eissn><abstract>•Significant association of VEGF mRNA with advanced clinical stages and adenocarcinoma histology in NSCLC.•VEGF mRNA (−ΔCT ≥10) was found to be associated with NSCLC.•Quantity of VEGF mRNA can be useful to predict the progression of NSCLC.
Elevated VEGF mRNA (−ΔCT) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan–Meier analysis showed that NSCLC patients with higher VEGF mRNA (−ΔCT ≥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of −ΔCT <10 (P < 0.001). The multivariable analysis confirmed that patients with higher VEGF mRNA levels, as well as with adenocarcinoma and advanced stages, were independent predictors of a poorer survival. However, only the histology of adenocarcinoma remained a significant prognostic factor of a shorter postoperative relapse in the multivariable model. Quantity of VEGF mRNA can be used as a prognosis factor to predict shorter overall survival in patients with NSCLC.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29025597</pmid><doi>10.1016/j.cancergen.2017.07.005</doi><tpages>7</tpages></addata></record> |
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| subjects | Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - surgery Case-Control Studies Disease Progression Female Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Linear Models Lung Neoplasms - genetics Lung Neoplasms - surgery Male Middle Aged Multivariate Analysis NSCLC Postoperative Care Prognosis progression RNA, Messenger - genetics RNA, Messenger - metabolism Up-Regulation - genetics Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism VEGF |
| title | Upregulation of vascular endothelial growth factor (VEGF), its role in progression and prognosis of non-small cell lung carcinoma |
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