Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2
There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013-15). In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were an...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2017-12, Vol.72 (12), p.3283-3287 |
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| creator | Arana, David M Ortega, Adriana González-Barberá, Eva Lara, Noelia Bautista, Verónica Gómez-Ruíz, Dolores Sáez, David Fernández-Romero, Sara Aracil, Belén Pérez-Vázquez, María Campos, José Oteo, Jesús |
| description | There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013-15).
In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.
Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI-blaVIM-1-aacA4-dfrB1-aadA1-catB2-qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.
We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications. |
| doi_str_mv | 10.1093/jac/dkx325 |
| format | Article |
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In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.
Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI-blaVIM-1-aacA4-dfrB1-aadA1-catB2-qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.
We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkx325</identifier><identifier>PMID: 29029114</identifier><language>eng</language><publisher>England</publisher><subject>Bacterial Proteins - genetics ; beta-Lactamases - genetics ; Carbapenem-Resistant Enterobacteriaceae - classification ; Carbapenem-Resistant Enterobacteriaceae - enzymology ; Carbapenem-Resistant Enterobacteriaceae - genetics ; Carbapenem-Resistant Enterobacteriaceae - isolation & purification ; Citrobacter - classification ; Citrobacter - enzymology ; Citrobacter - genetics ; Citrobacter - isolation & purification ; Electrophoresis, Gel, Pulsed-Field ; Enterobacteriaceae Infections - epidemiology ; Enterobacteriaceae Infections - microbiology ; Genetic Variation ; Genotype ; Humans ; Molecular Epidemiology ; Molecular Typing ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Spain - epidemiology</subject><ispartof>Journal of antimicrobial chemotherapy, 2017-12, Vol.72 (12), p.3283-3287</ispartof><rights>The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-ba3061e8ab3697e4d37cec844a1830154353c2f7670df97cf325931635aca3e83</citedby><cites>FETCH-LOGICAL-c323t-ba3061e8ab3697e4d37cec844a1830154353c2f7670df97cf325931635aca3e83</cites><orcidid>0000-0003-3327-8263</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29029114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arana, David M</creatorcontrib><creatorcontrib>Ortega, Adriana</creatorcontrib><creatorcontrib>González-Barberá, Eva</creatorcontrib><creatorcontrib>Lara, Noelia</creatorcontrib><creatorcontrib>Bautista, Verónica</creatorcontrib><creatorcontrib>Gómez-Ruíz, Dolores</creatorcontrib><creatorcontrib>Sáez, David</creatorcontrib><creatorcontrib>Fernández-Romero, Sara</creatorcontrib><creatorcontrib>Aracil, Belén</creatorcontrib><creatorcontrib>Pérez-Vázquez, María</creatorcontrib><creatorcontrib>Campos, José</creatorcontrib><creatorcontrib>Oteo, Jesús</creatorcontrib><creatorcontrib>Spanish Antibiotic Resistance Surveillance Programme Collaborating Group</creatorcontrib><title>Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013-15).
In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.
Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI-blaVIM-1-aacA4-dfrB1-aadA1-catB2-qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.
We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.</description><subject>Bacterial Proteins - genetics</subject><subject>beta-Lactamases - genetics</subject><subject>Carbapenem-Resistant Enterobacteriaceae - classification</subject><subject>Carbapenem-Resistant Enterobacteriaceae - enzymology</subject><subject>Carbapenem-Resistant Enterobacteriaceae - genetics</subject><subject>Carbapenem-Resistant Enterobacteriaceae - isolation & purification</subject><subject>Citrobacter - classification</subject><subject>Citrobacter - enzymology</subject><subject>Citrobacter - genetics</subject><subject>Citrobacter - isolation & purification</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Enterobacteriaceae Infections - epidemiology</subject><subject>Enterobacteriaceae Infections - microbiology</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Humans</subject><subject>Molecular Epidemiology</subject><subject>Molecular Typing</subject><subject>Polymerase Chain Reaction</subject><subject>Sequence Analysis, DNA</subject><subject>Spain - epidemiology</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctuFTEMhiNERQ-FDQ-AskTopE3iZC7Lari0aqFILYjdyJPxoClzI8mg9mV41qY9pRtbsj__sv0z9kbJQyVLOLpGd9T-vgFtn7GNMpkUWpbqOdtIkFbkxsI-exnCtZQys1nxgu3rUupSKbNh_yr0DS400Sg8hT5EnCKv-ujnBl0kz8OyHPI-zANGank_8csFU-z8PHItFfA432fLFz-3q0sM8r_oe4q3fO64e9LHQCHNu2Ft--kX_3H6Ragtv_h5LEyx5WffKqG3_OuHVOU4tQ99_YrtdTgEev2YD9j3Tx-vqhNxfvH5tDo-Fw40RNEgyExRgQ1kZU6mhdyRK4xBVUDazYAFp7s8y2Xblbnr0q9KUBlYdAhUwAF7t9NNR_xZKcR67IOjYcCJ5jXUqrTKqEJandD3O9T5OQRPXb34fkR_WytZ3_tRJz_qnR8JfvuouzYjtU_ofwPgDvMuguU</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Arana, David M</creator><creator>Ortega, Adriana</creator><creator>González-Barberá, Eva</creator><creator>Lara, Noelia</creator><creator>Bautista, Verónica</creator><creator>Gómez-Ruíz, Dolores</creator><creator>Sáez, David</creator><creator>Fernández-Romero, Sara</creator><creator>Aracil, Belén</creator><creator>Pérez-Vázquez, María</creator><creator>Campos, José</creator><creator>Oteo, Jesús</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3327-8263</orcidid></search><sort><creationdate>20171201</creationdate><title>Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2</title><author>Arana, David M ; Ortega, Adriana ; González-Barberá, Eva ; Lara, Noelia ; Bautista, Verónica ; Gómez-Ruíz, Dolores ; Sáez, David ; Fernández-Romero, Sara ; Aracil, Belén ; Pérez-Vázquez, María ; Campos, José ; Oteo, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-ba3061e8ab3697e4d37cec844a1830154353c2f7670df97cf325931635aca3e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bacterial Proteins - genetics</topic><topic>beta-Lactamases - genetics</topic><topic>Carbapenem-Resistant Enterobacteriaceae - classification</topic><topic>Carbapenem-Resistant Enterobacteriaceae - enzymology</topic><topic>Carbapenem-Resistant Enterobacteriaceae - genetics</topic><topic>Carbapenem-Resistant Enterobacteriaceae - isolation & purification</topic><topic>Citrobacter - classification</topic><topic>Citrobacter - enzymology</topic><topic>Citrobacter - genetics</topic><topic>Citrobacter - isolation & purification</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Enterobacteriaceae Infections - epidemiology</topic><topic>Enterobacteriaceae Infections - microbiology</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Humans</topic><topic>Molecular Epidemiology</topic><topic>Molecular Typing</topic><topic>Polymerase Chain Reaction</topic><topic>Sequence Analysis, DNA</topic><topic>Spain - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arana, David M</creatorcontrib><creatorcontrib>Ortega, Adriana</creatorcontrib><creatorcontrib>González-Barberá, Eva</creatorcontrib><creatorcontrib>Lara, Noelia</creatorcontrib><creatorcontrib>Bautista, Verónica</creatorcontrib><creatorcontrib>Gómez-Ruíz, Dolores</creatorcontrib><creatorcontrib>Sáez, David</creatorcontrib><creatorcontrib>Fernández-Romero, Sara</creatorcontrib><creatorcontrib>Aracil, Belén</creatorcontrib><creatorcontrib>Pérez-Vázquez, María</creatorcontrib><creatorcontrib>Campos, José</creatorcontrib><creatorcontrib>Oteo, Jesús</creatorcontrib><creatorcontrib>Spanish Antibiotic Resistance Surveillance Programme Collaborating Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arana, David M</au><au>Ortega, Adriana</au><au>González-Barberá, Eva</au><au>Lara, Noelia</au><au>Bautista, Verónica</au><au>Gómez-Ruíz, Dolores</au><au>Sáez, David</au><au>Fernández-Romero, Sara</au><au>Aracil, Belén</au><au>Pérez-Vázquez, María</au><au>Campos, José</au><au>Oteo, Jesús</au><aucorp>Spanish Antibiotic Resistance Surveillance Programme Collaborating Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>72</volume><issue>12</issue><spage>3283</spage><epage>3287</epage><pages>3283-3287</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013-15).
In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.
Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI-blaVIM-1-aacA4-dfrB1-aadA1-catB2-qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.
We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.</abstract><cop>England</cop><pmid>29029114</pmid><doi>10.1093/jac/dkx325</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3327-8263</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Current; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Bacterial Proteins - genetics beta-Lactamases - genetics Carbapenem-Resistant Enterobacteriaceae - classification Carbapenem-Resistant Enterobacteriaceae - enzymology Carbapenem-Resistant Enterobacteriaceae - genetics Carbapenem-Resistant Enterobacteriaceae - isolation & purification Citrobacter - classification Citrobacter - enzymology Citrobacter - genetics Citrobacter - isolation & purification Electrophoresis, Gel, Pulsed-Field Enterobacteriaceae Infections - epidemiology Enterobacteriaceae Infections - microbiology Genetic Variation Genotype Humans Molecular Epidemiology Molecular Typing Polymerase Chain Reaction Sequence Analysis, DNA Spain - epidemiology |
| title | Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
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