Germ Cell Neoplasia in Situ and Preserved Fertility Despite Suppressed Gonadotropins in a Patient With Testotoxicosis

ContextTestotoxicosis is an autosomal-dominant, male-limited disorder. Activating mutations in the luteinizing hormone receptor gene (LHCGR) cause high autonomous testosterone secretion, resulting in early-onset peripheral precocious puberty. Little is known about long-term consequences of testotoxi...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2017-12, Vol.102 (12), p.4411-4416
Hauptverfasser:	Juel Mortensen, Li, Blomberg Jensen, Martin, Christiansen, Peter, Rønholt, Ann-Margrethe, Jørgensen, Anne, Frederiksen, Hanne, Nielsen, John E, Loya, Anand C, Grønkær Toft, Birgitte, Skakkebæk, Niels E, Rajpert-De Meyts, Ewa, Juul, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Adenoma Adult Age Biopsy Body Composition Body Height Bone and Bones - pathology Children Fertility Follicle-stimulating hormone Gonadotropins Gonadotropins - metabolism Hereditary diseases Hormone Antagonists - therapeutic use Humans Hyperplasia Inhibin Ketoconazole Ketoconazole - therapeutic use Lesions Leydig Cell Tumor - complications Leydig Cell Tumor - genetics Leydig Cell Tumor - pathology Luteinizing hormone Male Malignancy Mutation Neoplasms, Germ Cell and Embryonal - complications Neoplasms, Germ Cell and Embryonal - genetics Neoplasms, Germ Cell and Embryonal - pathology Patients Pituitary (anterior) Puberty Puberty, Precocious - complications Puberty, Precocious - etiology Receptors, LH - genetics Semen Spermatogenesis Testes Testicular cancer Testis - diagnostic imaging Testis - metabolism Testosterone Tubules Ultrasound
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