Interferon Tau Regulates Cytokine Production and Cellular Function in Human Trophoblast Cell Line

Type I interferons (IFN), including IFN-beta (IFNB), activate multiple STAT signaling to drive various biological responses. Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on hu...

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Veröffentlicht in:	Journal of interferon & cytokine research 2017-10, Vol.37 (10), p.456-466
Hauptverfasser:	Tanikawa, Nao, Seno, Kotomi, Kawahara-Miki, Ryouka, Kimura, Koji, Matsuyama, Shuichi, Iwata, Hisataka, Kuwayama, Takehito, Shirasuna, Koumei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animal sciences Cell culture Cell Line Cell migration Cell Movement Cell Proliferation Cells, Cultured Cellular manufacture Cytokines Cytokines - metabolism Cytotoxicity Female Gene expression Gene Expression Profiling Humans Inflammation Inflammation Mediators - metabolism Interferon Interferon Type I - biosynthesis Interferon Type I - metabolism Interleukin 6 Interleukin 8 Kinases Laboratories Mitochondria Multiple sclerosis Oxidation-Reduction Pregnancy Pregnancy Proteins - biosynthesis Reactive Oxygen Species - metabolism Rodents Signal Transduction Signaling Stat1 protein Stat3 protein Superoxide dismutase Superoxide Dismutase - metabolism Toxicity Trophoblasts - cytology Trophoblasts - metabolism Ubiquitins - metabolism Viral infections Zoology
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