Interferon Tau Regulates Cytokine Production and Cellular Function in Human Trophoblast Cell Line
Type I interferons (IFN), including IFN-beta (IFNB), activate multiple STAT signaling to drive various biological responses. Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on hu...
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| Veröffentlicht in: | Journal of interferon & cytokine research 2017-10, Vol.37 (10), p.456-466 |
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| creator | Tanikawa, Nao Seno, Kotomi Kawahara-Miki, Ryouka Kimura, Koji Matsuyama, Shuichi Iwata, Hisataka Kuwayama, Takehito Shirasuna, Koumei |
| description | Type I interferons (IFN), including IFN-beta (IFNB), activate multiple STAT signaling to drive various biological responses. Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on human trophoblast cell functions. First, we performed next-generation sequencing and demonstrated that IFNT-dependent changes in the human Sw.71 trophoblast cell line are partly mediated by proinflammatory as well as IFN signaling. Next, we validated candidate genes, and data confirmed that IFNT stimulated interleukin-6 (IL-6) and IL-8 mRNA expression and secretion. However, human IFNB did not affect IL-6 and IL-8 mRNA expression and secretion. IFNT-induced cytokine secretion was dependent on STAT3 signaling, but not STAT1 signaling. In addition, treatment with IFNT, IL-6, or IL-8 increased cell proliferation, and IFNT also stimulated cell migration in human trophoblast cells. Although IFNT did not affect superoxide dismutase (SOD) 1 mRNA expression, it clearly increased mitochondrial SOD2 mRNA expression, resulting in the acceleration of SOD activity. We demonstrated that in addition to IFN signaling, IFNT also regulated inflammation-related signaling as well as cell proliferation, migration, and redox signaling in human trophoblast cells. |
| doi_str_mv | 10.1089/jir.2017.0057 |
| format | Article |
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Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on human trophoblast cell functions. First, we performed next-generation sequencing and demonstrated that IFNT-dependent changes in the human Sw.71 trophoblast cell line are partly mediated by proinflammatory as well as IFN signaling. Next, we validated candidate genes, and data confirmed that IFNT stimulated interleukin-6 (IL-6) and IL-8 mRNA expression and secretion. However, human IFNB did not affect IL-6 and IL-8 mRNA expression and secretion. IFNT-induced cytokine secretion was dependent on STAT3 signaling, but not STAT1 signaling. In addition, treatment with IFNT, IL-6, or IL-8 increased cell proliferation, and IFNT also stimulated cell migration in human trophoblast cells. Although IFNT did not affect superoxide dismutase (SOD) 1 mRNA expression, it clearly increased mitochondrial SOD2 mRNA expression, resulting in the acceleration of SOD activity. We demonstrated that in addition to IFN signaling, IFNT also regulated inflammation-related signaling as well as cell proliferation, migration, and redox signaling in human trophoblast cells.</description><identifier>ISSN: 1079-9907</identifier><identifier>EISSN: 1557-7465</identifier><identifier>DOI: 10.1089/jir.2017.0057</identifier><identifier>PMID: 29028431</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animal reproduction ; Animal sciences ; Cell culture ; Cell Line ; Cell migration ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Cellular manufacture ; Cytokines ; Cytokines - metabolism ; Cytotoxicity ; Female ; Gene expression ; Gene Expression Profiling ; Humans ; Inflammation ; Inflammation Mediators - metabolism ; Interferon ; Interferon Type I - biosynthesis ; Interferon Type I - metabolism ; Interleukin 6 ; Interleukin 8 ; Kinases ; Laboratories ; Mitochondria ; Multiple sclerosis ; Oxidation-Reduction ; Pregnancy ; Pregnancy Proteins - biosynthesis ; Reactive Oxygen Species - metabolism ; Rodents ; Signal Transduction ; Signaling ; Stat1 protein ; Stat3 protein ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Toxicity ; Trophoblasts - cytology ; Trophoblasts - metabolism ; Ubiquitins - metabolism ; Viral infections ; Zoology</subject><ispartof>Journal of interferon & cytokine research, 2017-10, Vol.37 (10), p.456-466</ispartof><rights>(©) Copyright 2017, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-c5b9e5f988e87003cbec2ca4c913c7d9866be8d76b099e22c48dcdf1471260653</citedby><cites>FETCH-LOGICAL-c321t-c5b9e5f988e87003cbec2ca4c913c7d9866be8d76b099e22c48dcdf1471260653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29028431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanikawa, Nao</creatorcontrib><creatorcontrib>Seno, Kotomi</creatorcontrib><creatorcontrib>Kawahara-Miki, Ryouka</creatorcontrib><creatorcontrib>Kimura, Koji</creatorcontrib><creatorcontrib>Matsuyama, Shuichi</creatorcontrib><creatorcontrib>Iwata, Hisataka</creatorcontrib><creatorcontrib>Kuwayama, Takehito</creatorcontrib><creatorcontrib>Shirasuna, Koumei</creatorcontrib><title>Interferon Tau Regulates Cytokine Production and Cellular Function in Human Trophoblast Cell Line</title><title>Journal of interferon & cytokine research</title><addtitle>J Interferon Cytokine Res</addtitle><description>Type I interferons (IFN), including IFN-beta (IFNB), activate multiple STAT signaling to drive various biological responses. Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on human trophoblast cell functions. First, we performed next-generation sequencing and demonstrated that IFNT-dependent changes in the human Sw.71 trophoblast cell line are partly mediated by proinflammatory as well as IFN signaling. Next, we validated candidate genes, and data confirmed that IFNT stimulated interleukin-6 (IL-6) and IL-8 mRNA expression and secretion. However, human IFNB did not affect IL-6 and IL-8 mRNA expression and secretion. IFNT-induced cytokine secretion was dependent on STAT3 signaling, but not STAT1 signaling. In addition, treatment with IFNT, IL-6, or IL-8 increased cell proliferation, and IFNT also stimulated cell migration in human trophoblast cells. Although IFNT did not affect superoxide dismutase (SOD) 1 mRNA expression, it clearly increased mitochondrial SOD2 mRNA expression, resulting in the acceleration of SOD activity. We demonstrated that in addition to IFN signaling, IFNT also regulated inflammation-related signaling as well as cell proliferation, migration, and redox signaling in human trophoblast cells.</description><subject>Animal reproduction</subject><subject>Animal sciences</subject><subject>Cell culture</subject><subject>Cell Line</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Cellular manufacture</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Cytotoxicity</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interferon</subject><subject>Interferon Type I - biosynthesis</subject><subject>Interferon Type I - metabolism</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Mitochondria</subject><subject>Multiple sclerosis</subject><subject>Oxidation-Reduction</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - 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Academic</collection><jtitle>Journal of interferon & cytokine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanikawa, Nao</au><au>Seno, Kotomi</au><au>Kawahara-Miki, Ryouka</au><au>Kimura, Koji</au><au>Matsuyama, Shuichi</au><au>Iwata, Hisataka</au><au>Kuwayama, Takehito</au><au>Shirasuna, Koumei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interferon Tau Regulates Cytokine Production and Cellular Function in Human Trophoblast Cell Line</atitle><jtitle>Journal of interferon & cytokine research</jtitle><addtitle>J Interferon Cytokine Res</addtitle><date>2017-10</date><risdate>2017</risdate><volume>37</volume><issue>10</issue><spage>456</spage><epage>466</epage><pages>456-466</pages><issn>1079-9907</issn><eissn>1557-7465</eissn><abstract>Type I interferons (IFN), including IFN-beta (IFNB), activate multiple STAT signaling to drive various biological responses. Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on human trophoblast cell functions. First, we performed next-generation sequencing and demonstrated that IFNT-dependent changes in the human Sw.71 trophoblast cell line are partly mediated by proinflammatory as well as IFN signaling. Next, we validated candidate genes, and data confirmed that IFNT stimulated interleukin-6 (IL-6) and IL-8 mRNA expression and secretion. However, human IFNB did not affect IL-6 and IL-8 mRNA expression and secretion. IFNT-induced cytokine secretion was dependent on STAT3 signaling, but not STAT1 signaling. In addition, treatment with IFNT, IL-6, or IL-8 increased cell proliferation, and IFNT also stimulated cell migration in human trophoblast cells. Although IFNT did not affect superoxide dismutase (SOD) 1 mRNA expression, it clearly increased mitochondrial SOD2 mRNA expression, resulting in the acceleration of SOD activity. We demonstrated that in addition to IFN signaling, IFNT also regulated inflammation-related signaling as well as cell proliferation, migration, and redox signaling in human trophoblast cells.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>29028431</pmid><doi>10.1089/jir.2017.0057</doi><tpages>11</tpages></addata></record> |
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| subjects | Animal reproduction Animal sciences Cell culture Cell Line Cell migration Cell Movement Cell Proliferation Cells, Cultured Cellular manufacture Cytokines Cytokines - metabolism Cytotoxicity Female Gene expression Gene Expression Profiling Humans Inflammation Inflammation Mediators - metabolism Interferon Interferon Type I - biosynthesis Interferon Type I - metabolism Interleukin 6 Interleukin 8 Kinases Laboratories Mitochondria Multiple sclerosis Oxidation-Reduction Pregnancy Pregnancy Proteins - biosynthesis Reactive Oxygen Species - metabolism Rodents Signal Transduction Signaling Stat1 protein Stat3 protein Superoxide dismutase Superoxide Dismutase - metabolism Toxicity Trophoblasts - cytology Trophoblasts - metabolism Ubiquitins - metabolism Viral infections Zoology |
| title | Interferon Tau Regulates Cytokine Production and Cellular Function in Human Trophoblast Cell Line |
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