FOXP3, ICOS and ICOSL gene polymorphisms in systemic sclerosis: FOXP3 rs2294020 is associated with disease progression in a female Italian population

•FOXP3, ICOS and ICOSL SNPs were tested for association with SSc susceptibility and progression.•Significant association between rs2294020 and SSc progression in females was found.•Rs2294020 may be considered a disease-modifying gene-variant in SSc. Systemic sclerosis (SSc), an autoimmune disorder,...

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Veröffentlicht in:	Immunobiology (1979) 2018-01, Vol.223 (1), p.112-117
Hauptverfasser:	D'Amico, Fabio, Fiorito, Giovanni, Skarmoutsou, Evangelia, Granata, Mariagrazia, Rossi, Giulio A., Trovato, Chiara, Bellocchi, Chiara, Marchini, Maurizio, Beretta, Lorenzo, Mazzarino, Maria Clorinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Disease Progression Female Forkhead Transcription Factors - genetics FOXP3 Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Humans ICOS ICOSL Inducible T-Cell Co-Stimulator Ligand - genetics Inducible T-Cell Co-Stimulator Protein - genetics Italy Middle Aged Polymorphism, Single Nucleotide Scleroderma, Systemic - genetics Single nucleotide polymorphism Systemic sclerosis
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