The archaic roles of the lamprey NF-κB (lj-NF-κB) in innate immune responses

•lj-NF-κB gene was identified from lamprey after screening of a leukocytes cDNA library for the first time.•We found lj-NF-κB could bind DNA and regulates genes expression.•We found the ANKs of lj-NF-κB were the inhibition signal for the RHD of lj-NF-κB.•Our research provides a new paradigm of the v...

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