Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells

Thymidylate synthase (TS) overexpression is a key determinant of 5-fluorouracil (5-FU) resistance in human cancer cells. TS is also acutely up-regulated with 5-FU treatment, and, thus, novel strategies targeting TS down-regulation seem to be promising in terms of modulating 5-FU resistance. Here, we...

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Veröffentlicht in:	Molecular cancer therapeutics 2006-12, Vol.5 (12), p.3085-3095
Hauptverfasser:	Lee, Ju-Hee, Park, Jung-Hyun, Jung, Yeonjoo, Kim, Jee-Hyun, Jong, Hyun-Soon, Kim, Tae-You, Bang, Yung-Jue
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil Acetylation - drug effects Antineoplastic Combined Chemotherapy Protocols - pharmacology Cell Line, Tumor Cycloheximide - pharmacology Dose-Response Relationship, Drug Down-Regulation - drug effects Drug Resistance, Neoplasm Drug Synergism Fluorouracil - administration & dosage Fluorouracil - pharmacology heat shock protein 90 acetylation histone deacetylase inhibitor Histone Deacetylase Inhibitors Histone Deacetylases - genetics Histone Deacetylases - metabolism HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - metabolism Humans Hydroxamic Acids - administration & dosage Hydroxamic Acids - pharmacology Neoplasms - drug therapy Neoplasms - enzymology Proteasome Endopeptidase Complex - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics thymidylate synthase Thymidylate Synthase - biosynthesis Thymidylate Synthase - genetics Thymidylate Synthase - metabolism trichostatin A
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