Synthesis and structure–activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells

New taxoids bearing a bulky acyloxy group at C-2, C-5, C-7, C-9, C-10, and C-14 were obtained by chemical and bio- transformations of taxuyunnanine C and its analogs. In them, compounds 3, 5, 6, 8, and 9a have significant effects of the accumulation of calcein in MDR 2780AD. Since compounds 6 and 8...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (13), p.3722-3728
Hauptverfasser:	Hasegawa, Toshiaki, Bai, Jiao, Dai, Jungui, Bai, Liming, Sakai, Junichi, Nishizawa, Shigenori, Bai, Yuhua, Kikuchi, Midori, Abe, Mariko, Yamori, Takao, Tomida, Akihiro, Tsuruo, Takashi, Hirose, Katsutoshi, Ando, Masayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Biological Assay Cell Line Cell Line, Tumor Chemistry, Pharmaceutical - methods Cytotoxicity Drug Design Drug Resistance, Multiple Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Fluoresceins - chemistry General aspects Humans Inhibitory Concentration 50 MDR Medical sciences Models, Chemical Pharmacology. Drug treatments Structure-Activity Relationship Taxoid Taxoids - chemical synthesis Taxoids - chemistry Taxuyunnanine C
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